Results 41 to 50 of about 20,920 (295)

A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes [PDF]

, 2014
Myristoylation is a lipid modification involving the addition of a 14-carbon unsaturated fatty acid, myristic acid, to the N-terminal glycine of a subset of proteins, a modification that promotes their binding to cell membranes for varied biological ...
Carlow, Clotilde K. S., Chapman, Melissa S., Galvin, Brendan D., Li, Zhiru, Pollastri, Michael P., Poole, Catherine B., Villemaine, Estelle, Wyatt, Paul G.   +7 more
core   +4 more sources

Stage-specific proteomes from onchocerca ochengi, sister species of the human river blindness parasite, uncover adaptations to a nodular lifestyle [PDF]

, 2016
Despite 40 years of control efforts, onchocerciasis (river blindness) remains one of the most important neglected tropical diseases, with 17 million people affected.
Adam, Altschul, Altschul, Anon, Argueta, Armstrong, Armstrong, Arumugam, Babayan, Bazzocchi, Bendtsen, Benjamini, Bennuru, Bennuru, Berry, Berry, Board, Boatin, Brattig, Brattig, Brophy, Bulman, Burbelo, Burchard, Burket, Butler, Chandrashekar, Chawade, Chhabra, Choi, Claros, Constam, Cooray, Crump, Darby, Darby, Desjardins, Duckert, Edgar, Edwards, Erttmann, Finn, Franceschini, Frank, Gallin, Gardon, GBD 2013 Mortality and Causes of Death Collaborators, Geary, Ghali, Ghedin, Ghosh, Gilbert, Globisch, Godel, Gomez-Escobar, Gopal, Gotenstein, Gottsch, Grainger, Gretes, Guan, Guiliano, Hansen, Henrichfreise, Hewitson, Hewitson, Hewitson, Hotez, Hunter, Ichishita, Joseph, Joza, Kanazawa, Klion, Ko, Koonin, Korten, Krogh, Larkin, Li, Li, Liebau, Liebau, Liebau, Liebau, Littler, Liu, Longo, Lu, Lundquist, Lustigman, Lustigman, Mackenzie, Makepeace, Marti, McGarry, McSorley, Melnikow, Meyer, Michalski, Morales-Hojas, Moreno, Moreno, Morris, Mossmann, Nana-Djeunga, Nfon, Nicholson, Nomura, Ohtsuki, Ohtsuki, Osei-Atweneboana, Page, Pant, Parra, Petersen, Plaisier, Quintana, Ranjan, Rew, Rogalski, Roth, Saitou, Schulz-Key, Schulz-Key, Scocchi, Sheehan, Silva, Sommer, Srivastava, Tamarozzi, Tanikawa, Taylor, Tchakouté, Ternent, Tew, Thompson, Tiwari, Trees, Vogel, Wahl, Waterhouse, Westermann, Wildenburg, Willenbucher, Wilson, Wisniewski, Wu, Wu, Xie, Xie, Yamaguchi, Yang, Yasuda, Zanetti, Zipfel   +155 more
core   +6 more sources

Evidence against Wolbachia symbiosis in Loa loa [PDF]

, 2003
BACKGROUND: The majority of filarial nematode species are host to Wolbachia bacterial endosymbionts, although a few including Acanthocheilonema viteae, Onchocerca flexuosa and Setaria equina have been shown to be free of infection. Comparisons of species
Akue, Jean-Paul, Beeching, Nick J, Bianco, Albert E, Egerton, Gill, Enyong, Peter, Hoerauf, Achim, Kläger, Sabine L, McGarry, Helen F, Pfarr, Ken, Taylor, Mark J, Wanji, Samuel   +10 more
core   +2 more sources

Onchocerca eberhardi n. sp. (Nematoda: Filarioidea) from sika deer in Japan; relationships between species parasitic in cervids and bovids in the Holarctic region

Parasite, 2007
Onchocerca eberhardi n. sp. from the sika deer, Cervus nippon, in Japan is described. Adult worms lived in the carpal ligament; infection reached high levels (up to 25 female and 16 male worms in a single carpal limb).
Uni S., Bain O., Agatsuma T., Harada M., Torii H., Fukuda M., Takaoka H.   +6 more
doaj   +1 more source

Nodding syndrome (NS) and Onchocerca Volvulus (OV) in Northern Uganda

The Pan African Medical Journal, 2017
Nodding Syndrome (NS) is a childhood neurological disorder characterized by atonic seizures, cognitive decline, school dropout, muscle weakness, thermal dysfunction, wasting and stunted growth.
David Kitara Lagoro, Denis Anywar Arony
doaj   +1 more source

The macrofilaricidal efficacy of repeated doses of ivermectin for the treatment of river blindness [PDF]

, 2017
Background: Mass drug administration (MDA) with ivermectin is the cornerstone of efforts to eliminate human onchocerciasis by 2020 or 2025. The feasibility of elimination crucially depends on the effects of multiple ivermectin doses on Onchocerca ...
Basáñez, Maria-Gloria, Boussinesq, Michel, Chesnais, Cédric, Chippaux, Jean-Philippe, Ernould, Jean-Christophe, Fang, Hanwei, Garcia, André, Gardon, J., Kamgno, Joseph, Pion, Sébastien, Ranque, Stephane, Tchatchueng-Mbougua, Jules Brice, Walker, Martin   +12 more
core   +2 more sources

Molecular identification of infective larvae of three species of Onchocerca found in wild-caught females of Simulium bidentatum in Japan

Parasite, 2010
Wild female black flies attracted to a man or an idling automobile were collected at Oita, Japan where five cases of zoonotic onchocerciasis had occurred.
Fukuda M., Otsuka Y., Uni S., Bain O., Takaoka H.   +4 more
doaj   +1 more source

The kunitz domain protein BLI-5 plays a functionally conserved role in cuticle formation in a diverse range of nematodes [PDF]

, 2010
The cuticle of parasitic nematodes performs many critical functions and is essential for proper development and for protection from the host immune response.
Antony P. Page, Bernard, Blaxter, Chu, Cook, Fessler, Ford, Frand, Ghedin, Gillian McCormack, Gillian Stepek, Hawdon, Johnstone, Johnstone, Kingston, Kingston, Kramerova, Kramerova, Kress, Mieszczanek, Milstone, Nagano, Novelli, Novelli, Paesen, Page, Page, Poole, Priess, Redmond, Rhoads, Sasaki, Scott, Shamansky, Skuce, Stanssens, Studier, Thacker, Thacker, Thacker, Thacker, Thein, Wells, Winter   +43 more
core   +1 more source

Zoonotic onchocerciasis caused by a parasite from wild boar in Oita, Japan

Parasite, 2004
Histological examination of a nodule removed from the back of the hand of a 58-year-old woman from Oita, Kyushu, Japan showed an Onchocerca female sectioned through the posterior region of the worm (ovaries identifiable) and young (thin cuticle).
Takaoka H., Bain O., Uni S., Korenaga M., Kozek W.J., Shirasaka C., Aoki C., Otsuka Y., Fukuda M., Eshita Y., Daa T.   +10 more
doaj   +1 more source

Evidence of suppression of onchocerciasis transmission in the Venezuelan Amazonian focus. [PDF]

, 2016
BACKGROUND: The World Health Organization (WHO) has set goals for onchocerciasis elimination in Latin America by 2015. Most of the six previously endemic countries are attaining this goal by implementing twice a year (and in some foci, quarterly) mass ...
Basanez, MG, Borges, D, Botto, C, Camacho, O, Coronel, P, Cortez, J, Escalona, M, Flores, J, Frontado, H, Graterol, B, Grillet, ME, Guerra, F, Margeli, H, Morales, AL, Noya-Alarcón, O, Rodriguez, MA, Ríos, D, Tovar, Y, Unnasch, TR, Villamizar, NJ, Vivas-Martínez, S   +20 more
core   +2 more sources