Abstract Recent years have seen major advances in tau‐associated brain disorders through interdisciplinary research spanning molecular biology, neuroimaging, clinical trials, and therapeutic development. The Tau2024 Global Conference, hosted by the Alzheimer's Association, CurePSP, and Rainwater Charitable Foundation, showcased these efforts by ...
Bess Frost+42 more
wiley +1 more source
A murine macrofilaricide pre-clinical screening model for onchocerciasis and lymphatic filariasis
Background New drugs effective against adult filariae (macrofilaricides) would accelerate the elimination of lymphatic filariasis and onchocerciasis. Anti-Onchocerca drug development is hampered by the lack of a facile model. We postulated that SCID mice
Alice Halliday+13 more
doaj +1 more source
Onchocerca armillata (Railliet et Henry, 1909) d'un nouvel hôte, Camelus dromedarius
Onchocerca armillata a été observé dans l'aorte d'un dromadaire, à l'abattoir de Kano, sur les 53 animaux ...
T.W. Schillhorn Van Veen+2 more
doaj +1 more source
How can onchocerciasis elimination in Africa be accelerated? Modelling the impact of increased ivermectin treatment frequency and complementary vector control [PDF]
Background: Great strides have been made toward onchocerciasis elimination by mass drug administration (MDA) of ivermectin. Focusing on MDA-eligible areas, we investigated where the elimination goal can be achieved by 2025 by continuation of current ...
Afework H Tekle+59 more
core +3 more sources
Maternal IgE Influence on Fetal and Infant Health
ABSTRACT Immunoglobulin E (IgE) is the most recently discovered and evolved mammalian antibody type, best known for interacting with mast cells (MCs) as immune effectors. IgE‐mediated antigen sensing by MC provides protection from parasites, venomous animals, bacteria, and other insults to barrier tissues exposed to the environment.
Jozef Balla+2 more
wiley +1 more source
Genetic and environmental risk factors for dementia in African adults: A systematic review
Abstract Dementia, a leading cause of global mortality, disproportionately impacts sub‐Saharan Africans due to complex genetic and environmental interactions. This systematic review evaluated dementia risk factors among sub‐Saharan Africans, identifying significant genetic and environmental influences using the Preferred Reporting Items for Systematic ...
David Mawutor Donkor+7 more
wiley +1 more source
Onchocerca Dewittei Japonica N. Subsp., a common parasite from wild in Kyushu Island, Japan
We describe Onchocerca dewittei japonica n. subsp. from the Japanese wild boar, Sus scrofa leucomystax, in Oita, Kyushu Island, where all seven animals examined were found to be infected. This study began with efforts to identify the causative species in
Uni S.+4 more
doaj +1 more source
Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis.
Two major human diseases caused by filariid nematodes are onchocerciasis, or river blindness, and lymphatic filariasis, which can lead to elephantiasis.
Christina A Bulman+24 more
doaj +1 more source
Australian guidelines for equine internal parasite management
Over the past few decades, the emergence of resistance amongst intestinal parasites of horses to all available anthelmintic classes has emphasised the need for a paradigm shift in parasite control approaches within the Australian equine industry. Findings of a recent Australia‐wide research project have provided new insights into intestinal parasites ...
A Beasley+12 more
wiley +1 more source
Of mice, cattle, and humans: the immunology and treatment of river blindness.
River blindness is a seriously debilitating disease caused by the filarial parasite Onchocerca volvulus, which infects millions in Africa as well as in South and Central America. Research has been hampered by a lack of good animal models, as the parasite
Judith E Allen+10 more
doaj +1 more source