Results 101 to 110 of about 31,479 (242)

Ivermectin as a promising therapeutic option for onchocerciasis‐associated epilepsy

Epilepsia Open, Volume 10, Issue 1, Page 361-367, February 2025.
Abstract Onchocerciasis, commonly known as river blindness, is a neglected tropical disease caused by the parasite Onchocerca volvulus. It can lead to blindness and visual impairment. Studies have also demonstrated a link between onchocerciasis and epilepsy, with there being a correlation between onchocerciasis endemicity and epilepsy prevalence ...
Mohammad Amin Manavi, Razieh Mohammad Jafari, Hamed Shafaroodi, Mohammad Sharifzadeh, Ahmad Reza Dehpour   +4 more
wiley   +1 more source

Research for new drugs for elimination of onchocerciasis in Africa

International Journal for Parasitology: Drugs and Drug Resistance, 2016
Onchocerciasis is a parasitic, vector borne disease caused by the filarial nematode Onchocerca volvulus. More than 99% of the population at risk of infection live in Africa. Onchocerciasis control was initiated in West Africa in 1974 with vector control,
Annette C. Kuesel
doaj   +1 more source

Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity

bioRxiv, 2016
Background Treatment of onchocerciasis using mass ivermectin administration has reduced morbidity and transmission throughout Africa and Central/South America.
S. Doyle, Catherine Bourguinat, H. Nana-Djeunga, Jonas A Kengne-Ouafo, S. Pion, J. Bopda, J. Kamgno, S. Wanji, H. Che, A. Kuesel, M. Walker, M. Basáñez, D. Boakye, M. Osei-Atweneboana, M. Boussinesq, R. Prichard, W. Grant   +16 more
semanticscholar   +1 more source

Exploring Glaucoma: From Pathogenesis to Emerging Diagnostic and Management Strategies

Journal of Ophthalmology, Volume 2025, Issue 1, 2025.
Glaucoma is a leading cause of irreversible blindness globally, affecting millions of individuals. It encompasses a group of progressive optic neuropathies characterized by retinal ganglion cell loss and visual field deterioration, often associated with elevated intraocular pressure.
Rajesh Kumar Goit, Nilufer Yesilirmak
wiley   +1 more source

Integrating multiple biomarkers to increase sensitivity for the detection of Onchocerca volvulus infection.

Journal of Infectious Diseases, 2019
Serological assessments for human onchocerciasis are based on IgG4 reactivity against the OV-16 antigen, with sensitivity around 60-80%. We previously identified 7 novel proteins that could enhance onchocerciasis sero-diagnosis.
S. Bennuru, Georgiette Oduro-Boateng, Chinweoke Osigwe, Priscilla Del-Valle, A. Golden, G. Ogawa, V. Cama, S. Lustigman, T. Nutman   +8 more
semanticscholar   +1 more source

Neglected Tropical Diseases and Female Infertility: Possible Pathophysiological Mechanisms

Journal of Tropical Medicine, Volume 2025, Issue 1, 2025.
Battling female infertility has posed a global challenge, where neglected tropical diseases (NTDs) are nonetheless a notable contributing factor. NTDs affect a variety of diseases, often of a chronic nature, which are often cited as some of the most lethal diseases operating against the most economically disadvantaged populations across the globe.
Moses Agbomhere Hamed, Olabanji Ahmed Surakat, Victor Olukayode Ekundina, Kabirat Bolajoko Jimoh, Adetomiwa Ezekiel Adeogun, Nafisat Omolola Akanji, Oluwafemi Joshua Babalola, Patrick Chukwunonso Eya, Rajib Chowdhury   +8 more
wiley   +1 more source

MRI Findings in People with Epilepsy and Nodding Syndrome in an Area Endemic for Onchocerciasis: An Observational Study. [PDF]

, 2013
Onchocerciasis has been implicated in the pathogenesis of epilepsy. The debate on a potential causal relationship between Onchocerca volvulus and epilepsy has taken a new direction in the light of the most recent epidemic of nodding syndrome. To document
Dharsee, J, Friedrich, K, Gotwald, T, Jilek-Aall, L, Kidunda, A, König, R, Matuja, W, Meindl, M, Müller, T H, Nassri, A, Schmutzhard, E, Velicheti, S, Winkler, A S   +12 more
core   +2 more sources

Evaluation of the Diagnostic Performance of Onchocerca volvulus Linear Epitopes in a Peptide Enzyme-Linked Immunosorbent Assay

American Journal of Tropical Medicine and Hygiene, 2018
. Diagnostic tools for the detection of infection with Onchocerca volvulus are presently limited to microfilaria detection in skin biopsies and serological assessment using the Ov16 immunoglobulin G4 (IgG4) rapid test, both of which have limited ...
Ole Lagatie, A. Verheyen, E. Nijs, Bieke van Dorst, Linda Batsa Debrah, A. Debrah, T. Supali, E. Sartono, L. Stuyver   +8 more
semanticscholar   +1 more source

Nodules sous-cutanés et lésions cutanées engendrés par diverses onchocerques chez des bovins africains

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1994
Des nodules sous-cutanés et de la peau ombilicale sont prélevés sur 6 Bos indicus onchocerquiens au Cameroun, pour l'étude anatomopathologiq ue. Les nodules à Onchocerca ochengi et Onchocerca dukei ont la même structure que celle des nodules à Onchocerca
P.N. Vuong, S. Wanji, J. Prod'Hon, O. Bain   +3 more
doaj   +1 more source

Development of emodepside as a possible adulticidal treatment for human onchocerciasis-The fruit of a successful industrial-academic collaboration.

PLoS Pathogens, 2021
Current mass drug administration (MDA) programs for the treatment of human river blindness (onchocerciasis) caused by the filarial worm Onchocerca volvulus rely on ivermectin, an anthelmintic originally developed for animal health.
Jürgen Krücken, Lindy Holden-Dye, Jennifer Keiser, Roger K Prichard, Simon Townson, Benjamin L Makepeace, Marc P Hübner, Steffen R Hahnel, Ivan Scandale, Achim Harder, Daniel Kulke   +10 more
doaj   +1 more source