Reductions in microfilaridermia by repeated ivermectin treatment are associated with lower Plasmodium-specific Th17 immune responses in Onchocerca volvulus-infected individuals [PDF]
, 2015 Background: 37 million individuals are currently infected with Onchocerca volvulus (O. volvulus), a parasitic nematode that elicits various dermal manifestations and eye damage in man. Disease control is primarily based on distributing ivermectin in mass
Arndts, Kathrin +8 more
core +1 more source
Microbes Saving Lives and Reducing Suffering
Microbial Biotechnology, Volume 18, Issue 1, January 2025.
Kenneth Timmis +26 more
wiley +1 more source
Neurological manifestations in Onchocerca volvulus infection: A review
Brain Research Bulletin, 2019 Human onchocerciasis, caused by infection by the filarial nematode Onchocerca volvulus, is a major neglected public health problem that affects millions of people in the endemic regions of sub-Saharan Africa and Latin America. Onchocerciasis is known to be associated with skin and eye disease and more recently, neurological features have been ...
An Hotterbeekx +4 more
openaire +3 more sources
Irreversible Effects of Ivermectin on Adult Parasites in Onchocerciasis Patients in the Onchocerciasis Control Programme in West Africa [PDF]
, 2017 Ivermectin is an effective drug for the treatment of human onchocerciasis, a disease caused by the parasitic filarial nematode Onchocerca volvulus.
Alley, E. Soumbey +7 more
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A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes [PDF]
, 2014 Myristoylation is a lipid modification involving the addition of a 14-carbon unsaturated fatty acid, myristic acid, to the N-terminal glycine of a subset of proteins, a modification that promotes their binding to cell membranes for varied biological ...
Carlow, Clotilde K. S. +7 more
core +4 more sources
Acta Amazonica, 2005 É acrescentado um novo caráter pupal para a espécie T. hirtipupa (Lutz,1910). É evidenciada a existência de dentes no cibário da fêmea de T. guianense (Wise,1911), principal espécie envolvida na transmissão da filaria Onchocerca volvulus (Leuckart,1893 ...
Victor PY-Daniel +4 more
doaj +1 more source
Ivermectin for onchocercal eye disease (river blindness).
, 2012 BACKGROUND: It is believed that ivermectin (a microfilaricide) could prevent blindness due to onchocerciasis. However, when given to everyone in communities where onchocerciasis is common, the effects of ivermectin on lesions affecting the eye are ...
Ejere, Henry OD +3 more
core +1 more source
The astacin metalloprotease moulting enzyme NAS-36 is required for normal cuticle ecdysis in free-living and parasitic nematodes [PDF]
, 2011 Nematodes represent one of the most abundant and species-rich groups of animals on the planet, with parasitic species causing chronic, debilitating infections in both livestock and humans worldwide. The prevalence and success of the nematodes is a direct
ANDREW J. BIRNIE +5 more
core +1 more source
Density-dependent processes in the transmission of human onchocerciasis: relationship between the numbers of microfilariae ingested and successful larval development in the simuliid vector [PDF]
, 2017 A previous paper reported that the intake of Onchocerca volvulus microfilariae (mff) by different species of Simulium is essentially proportional to the parasite load in the skin of infected carriers.
Alley, E. S. +6 more
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