Results 111 to 120 of about 31,479 (242)

Structures of Trichomonas vaginalis macrophage migratory inhibitory factor

Acta Crystallographica Section F, Volume 80, Issue 12, Page 341-347, December 2024.
The production, crystallization and three crystal structures of macrophage migratory inhibitory factor from T. vaginalis are reported.The unicellular parasitic protozoan Trichomonas vaginalis causes trichomoniasis, the most prevalent nonviral sexually transmitted disease globally. T.
Aruesha Srivastava, Aryana Nair, Omolara C. O. Dawson, Raymond Gao, Lijun Liu, Justin K. Craig, Kevin P. Battaile, Elizabeth K. Harmon, Lynn K. Barrett, Wesley C. Van Voorhis, Sandhya Subramanian, Peter J. Myler, Scott Lovell, Oluwatoyin A. Asojo, Rabih Darwiche   +14 more
wiley   +1 more source

Monoclonal Antibodies as Investigative Tools in Onchocerciasis [PDF]

, 2017
The development of monoclonal antibodies against parasites can facilitate analysis of host-parasite interactions and can lead to the identification and characterization of antigens that induce protective responses in the immunized host.
Weiss, Niklaus
core  

A Phase 1, Randomized, Double‐Blind, Placebo‐Controlled, Single Ascending Dose Trial of AWZ1066S, an Anti‐Wolbachia Candidate Macrofilaricide

Clinical Pharmacology in Drug Development, Volume 13, Issue 9, Page 1071-1081, September 2024.
Abstract AWZ1066S has been developed as a potential treatment for the neglected tropical diseases lymphatic filariasis and onchocerciasis. AWZ1066S targets the Wolbachia bacterial endosymbiont present in the causative nematode parasites. This phase 1, first‐in‐human study aimed to assess the safety and pharmacokinetics of AWZ1066S in healthy human ...
Graham Devereux, Marcin Bula, Karen Tripp, Richard Fitzgerald, Nicola Eraut, Muhammad Salman Alam, Tomoyuki Moriyama, Raku Shinkyo, Lauren Walker, Duolao Wang, Fabian Gusovsky, Jeannette van der Velde, Joseph D. Turner, Weiqian David Hong, Paul M. O'Neill, Mark J. Taylor, Stephen A. Ward   +16 more
wiley   +1 more source

The isolation of differentially expressed cDNA clones from the filarial nematode Brugia pahangi [PDF]

, 1999
A cDNA library constructed from 3 day post-infective L3 of the filarial nematode Brugia pahangi was screened by differential hybridization with cDNA probes prepared from different life-cycle stages.
Devaney, E., Hunter, S.J., Martin, S.A., Tetley, L., Thompson, F.J.   +4 more
core   +1 more source

Detection of Onchocerca volvulus in Skin Snips by Microscopy and Real-Time Polymerase Chain Reaction: Implications for Monitoring and Evaluation Activities.

American Journal of Tropical Medicine and Hygiene, 2016
Microscopic evaluation of skin biopsies is the monitoring and evaluation (M and E) method currently used by multiple onchocerciasis elimination programs in Africa.
E. Thiele, V. Cama, T. Lakwo, Sindeaw Mekasha, Francisca A Abanyie, Markos Sleshi, A. Kebede, P. Cantey   +7 more
semanticscholar   +1 more source

Potential effects of warmer worms and vectors on onchocerciasis transmission in West Africa [PDF]

, 2015
Development times of eggs, larvae and pupae of vectors of onchocerciasis (Simulium spp.) and of Onchocerca volvulus larvae within the adult females of the vectors decrease with increasing temperature.
Basáñez, Maria-Gloria, Boakye, Daniel A., Cheke, Robert A., Garms, Rolf, Intsiful, Joseph, Lamberton, Poppy H.L., Obuobie, E., Osei-Atweneboana, Mike Y., Perry, Malorie, Shen, Mingwang, White, Michale T., Wilson, Michael D., Young, Stephen   +12 more
core   +3 more sources

Synthesizing environmental, epidemiological and vector and parasite genetic data to assist decision making for disease elimination

Molecular Ecology, Volume 33, Issue 11, June 2024.
Abstract We present a framework for identifying when conditions are favourable for transmission of vector‐borne diseases between communities by incorporating predicted disease prevalence mapping with landscape analysis of sociological, environmental and host/parasite genetic data.
Himal Shrestha, Karen McCulloch, Rebecca H. Chisholm, Samuel K. Armoo, Francis Veriegh, Neha Sirwani, Katie E. Crawford, Mike Y. Osei‐Atweneboana, Warwick N. Grant, Shannon M. Hedtke   +9 more
wiley   +1 more source

Zoonotic onchocerciasis caused by a parasite from wild boar in Oita, Japan

Parasite, 2004
Histological examination of a nodule removed from the back of the hand of a 58-year-old woman from Oita, Kyushu, Japan showed an Onchocerca female sectioned through the posterior region of the worm (ovaries identifiable) and young (thin cuticle).
Takaoka H., Bain O., Uni S., Korenaga M., Kozek W.J., Shirasaka C., Aoki C., Otsuka Y., Fukuda M., Eshita Y., Daa T.   +10 more
doaj   +1 more source

Biochemical characterization and gene structure analysis of the 24‐kDa glutathione transferase sigma from Taenia solium

FEBS Open Bio, Volume 14, Issue 5, Page 726-739, May 2024.
Glutathione transferases (GST) are involved in detoxification and immunomodulation, allowing the establishment and development of cestodes in the host. Taenia solium has a 24‐kDa GST sigma class inducible gene that encodes a stable enzyme in a wide range of pHs and temperatures. Its enzymatic activity differs from other GSTs in the parasite, suggesting
Ricardo Miranda‐Blancas, Oscar Rodríguez‐Lima, Ponciano García‐Gutiérrez, Roberto Flores‐López, Lucía Jiménez, Rafael A. Zubillaga, Enrique Rudiño‐Piñera, Abraham Landa   +7 more
wiley   +1 more source

Density dependence and the control of helminth parasites.

, 2006
1. The transient dynamics and stability of a population are determined by the interplay between species density, its spatial distribution and the positive and negative density-dependent processes regulating population growth. 2.
Basáñez, María-Gloria, Churcher, Thomas S, Filipe, João AN   +2 more
core   +1 more source