Results 91 to 100 of about 28,317 (294)

In‐host modeling of dengue virus and non‐structural protein 1 and the effects of ivermectin in patients with acute dengue fever

CPT: Pharmacometrics &Systems Pharmacology, Volume 13, Issue 12, Page 2196-2209, December 2024.
Abstract The increased incidence of dengue poses a substantially global public health challenge. There are no approved antiviral drugs to treat dengue infections. Ivermectin, an old anti‐parasitic drug, had no effect on dengue viremia, but reduced the dengue non‐structural protein 1 (NS1) in a clinical trial.
Junjie Ding, Dumrong Mairiang, Dararat Prayongkul, Chunya Puttikhunt, Sansanee Noisakran, Nattapong Kaewjiw, Adisak Songjaeng, Tanapan Prommool, Nattaya Tangthawornchaikul, Nasikarn Angkasekwinai, Yupin Suputtamongkol, Keswadee Lapphra, Kulkanya Chokephaibulkit, Nicholas J. White, Panisadee Avirutnan, Joel Tarning   +15 more
wiley   +1 more source

Water resources development: engineering the future of global health [PDF]

, 2013
This repository item contains a single issue of Issues in Brief, a series of policy briefs that began publishing in 2008 by the Boston University Frederick S. Pardee Center for the Study of the Longer-Range Future.Pardee 2012 Summer Graduate Fellow Diana
Gergel, Diana
core   +1 more source

Mansonella perstans, Onchocerca volvulus and Strongyloides stercoralis infections in rural populations in central and southern Togo

Parasite Epidemiology and Control, 2018
Background: Mansonella perstans, Onchocerca volvulus and Strongyloides stercoralis are widespread helminth parasites in the tropics. Their distribution remains difficult to determine as it may change during national disease control programs and with ...
Francois Korbmacher, Kossi Komlan, Richard G. Gantin, Wiyao P. Poutouli, Koffi Padjoudoum, Potchoziou Karabou, Peter T. Soboslay, Carsten Köhler   +7 more
doaj  

Crystal structure of N‐terminally hexahistidine‐tagged Onchocerca volvulus macrophage migration inhibitory factor‐1

Acta Crystallographica Section F, Volume 80, Issue 12, Page 328-334, December 2024.
N‐terminally hexahistidine‐tagged O. volvulus macrophage migration inhibitory factor‐1 has a unique jellyfish‐like structure with the prototypical macrophage migration inhibitory factor trimer as the `head' and a C‐terminal extension as the `tail'.Onchocerca volvulus causes blindness, onchocerciasis, skin infections and devastating neurological ...
Amber D. Kimble, Omolara C. O. Dawson, Lijun Liu, Sandhya Subramanian, Anne Cooper, Kevin Battaile, Justin Craig, Elizabeth Harmon, Peter Myler, Scott Lovell, Oluwatoyin A. Asojo   +10 more
wiley   +1 more source

An appraisal of the neglected tropical diseases control program in Cameroon: the case of the national program against onchocerciasis

BMC Public Health, 2017
Background Onchocerciasis is a severe parasitic infestation which causes disabling skin and subcutaneous tissue changes. Current global estimates suggest that it accounts for 1135.7 disability adjusted life years (DALYs) per 100,000 population.
Tsi Njim, Leopold Ndemnge Aminde
doaj   +1 more source

Prevalence and determinants of scabies: A global systematic review and meta‐analysis

Tropical Medicine &International Health, Volume 29, Issue 12, Page 1006-1017, December 2024.
Abstract Objectives Scabies is a neglected skin disease that disproportionately affects people from resource poor and overcrowded countries. Global data on prevalence and risk factors are limited. This article aims to estimate the global burden of scabies and identifies the risks associated with it.
Saptorshi Gupta, Simon Thornley, Arthur Morris, Gerhard Sundborn, Cameron Grant   +4 more
wiley   +1 more source

Novel Patient‐Friendly Orodispersible Formulation of Ivermectin is Associated With Enhanced Palatability, Controlled Absorption, and Less Variability: High Potential for Pediatric Use

The Journal of Clinical Pharmacology, Volume 64, Issue 10, Page 1295-1303, October 2024.
Abstract Ivermectin has been used since the 1980s as an anthelmintic and antiectoparasite agent worldwide. Currently, the only available oral formulation is tablets designed for adult patients. A patient‐friendly orodispersible tablet formulation designed for pediatric use (CHILD‐IVITAB) has been developed and is entering early phase clinical trials ...
Kim Dao, Michael Buettcher, Klervi Golhen, Jonas Kost, Andreas Schittny, Urs Duthaler, Andrew Atkinson, David Haefliger, Monia Guidi, Carine Bardinet, Haithem Chtioui, Abdelwahab Boulekbache, Thierry Buclin, Jörg Huwyler, Marc Pfister, Laura E. Rothuizen   +15 more
wiley   +1 more source

Development of Onchocerca volvulus in humanized NSG mice and detection of parasite biomarkers in urine and serum. [PDF]

, 2018
BACKGROUND: The study of Onchocerca volvulus has been limited by its host range, with only humans and non-human primates shown to be susceptible to the full life cycle infection.
Abraham, David, Bennuru, Sasisekhar, Eberhard, Mark L., Hess Ligas, Jessica A., Lustigman, Sara, Nutman, Thomas B., Patton, John B., Torigian, April R.   +7 more
core   +3 more sources

Modelling exposure heterogeneity and density dependence in onchocerciasis using a novel individual-based transmission model, EPIONCHO-IBM: Implications for elimination and data needs

PLoS Neglected Tropical Diseases, 2019
Background Density dependence in helminth establishment and heterogeneity in exposure to infection are known to drive resilience to interventions based on mass drug administration (MDA).
Jonathan I D Hamley, Philip Milton, M. Walker, M. Basáñez   +3 more
semanticscholar   +1 more source

A study of case management challenge for black grain eumycetoma during the ongoing war in Sudan

Clinical Case Reports, Volume 12, Issue 9, September 2024.
Key Clinical Message This case highlights the significant challenges in the diagnosis and management of eumycetoma, particularly in regions like Sudan, where socioeconomic factors and ongoing conflict severely impact patient care. Delayed diagnosis and inadequate access to effective treatment can lead to poor adherence to prescribed therapies ...
Emmanuel Edwar Siddig, Imadeldin E. Aradaib, Ayman Ahmed   +2 more
wiley   +1 more source