Results 91 to 100 of about 28,700 (244)
Escalation of Germinal Center Responses in Chronic Litomosoides sigmodontis Filarial Infection
European Journal of Immunology, Volume 55, Issue 5, May 2025.T follicular helper (TFH) cells provide essential help to B cells in germinal centers (GCs). TFH and GC B cell responses are long‐lasting in draining mediastinal lymph nodes of Litomosoides sigmodontis‐infected BALB/c mice, a rodent model of filarial infection. ABSTRACT T follicular helper (TFH) cells are the primary CD4+ T helper cell subset providing
Teresa Steffen +9 more
wiley +1 more source
Onchocerciasis Fingerprints in the Geriatric Population: Does Host Immunity Play a Role?
Tropical Medicine and Infectious Disease, 2021 One of the most debilitating consequences of aging is the progressive decline in immune function, known as immunosenescence. This phenomenon is characterized by a shift in T-cell phenotypes, with a manifest decrease of naive T-cells—dealing with newly ...
Cabirou Mounchili Shintouo +6 more
doaj +1 more source
PLoS Neglected Tropical Diseases, 2019 Background High epilepsy prevalence and incidence were observed in onchocerciasis-endemic villages in the Democratic Republic of Congo (DRC). We investigated the clinical characteristics of onchocerciasis-associated epilepsy (OAE), and the relationship ...
J. S. Siewe Fodjo +12 more
semanticscholar +1 more source
A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes [PDF]
, 2014 Myristoylation is a lipid modification involving the addition of a 14-carbon unsaturated fatty acid, myristic acid, to the N-terminal glycine of a subset of proteins, a modification that promotes their binding to cell membranes for varied biological ...
Carlow, Clotilde K. S. +7 more
core +4 more sources
Journal of Agrarian Change, Volume 25, Issue 2, April 2025.ABSTRACT A capitalist agrarian transformation is unfolding in northern Ghana, marked by shifts in crop types, rapid increases in farm sizes and deepening rural social differentiation. This paper investigates these dynamics through a mixed‐methods approach across six farming communities in two districts, focusing on how social differentiation ...
Ibrahim Wahab +3 more
wiley +1 more source
Spatial clustering of onchocerciasis in Bioko Island, Equatorial Guinea
Journal of Infection in Developing Countries, 2018 Introduction: Onchocerciasis is a chronic neglected tropical disease caused by the filarial nematode Onchocerca volvulus, which is endemic in Equatorial Guinea.
Diana Gómez-Barroso +7 more
doaj +1 more source
“Rapid-Impact Interventions”: How a Policy of Integrated Control for Africa's Neglected Tropical Diseases Could Benefit the Poor [PDF]
, 2005 Controlling seven tropical infections in Africa would cost just 40 cents per person per year, and would permanently benefit hundreds of millions of ...
Alan Fenwick +14 more
core +6 more sources
Ivermectin as a promising therapeutic option for onchocerciasis‐associated epilepsy
Epilepsia Open, Volume 10, Issue 1, Page 361-367, February 2025.Abstract Onchocerciasis, commonly known as river blindness, is a neglected tropical disease caused by the parasite Onchocerca volvulus. It can lead to blindness and visual impairment. Studies have also demonstrated a link between onchocerciasis and epilepsy, with there being a correlation between onchocerciasis endemicity and epilepsy prevalence ...
Mohammad Amin Manavi +4 more
wiley +1 more source
Human infection with Gongylonema pulchrum [PDF]
, 1994 A 43 year old woman developed a painful tumor at the left buccal mucosa. Following local anti-inflammatory treatment a 35 mm long, living female adult worm of Gongylonema pulchrum was extracted from the affected side.
Jelinek, Thomas, Löscher, Thomas
core
FDA‐approved drugs featuring macrocycles or medium‐sized rings
Archiv der Pharmazie, Volume 358, Issue 1, January 2025.This review presents 17 macrocyclic drugs approved by the U.S. Food and Drug Administration during the past 5 years, highlighting their importance and critical role in modern therapeutics, and the innovative synthetic approaches for the construction of these macrocycles.
Youlong Du +7 more
wiley +1 more source