Results 111 to 120 of about 28,317 (294)

Pharmacokinetics, safety, and efficacy of a single co-administered dose of diethylcarbamazine, albendazole and ivermectin in adults with and without Wuchereria bancrofti infection in Cote d\u27Ivoire [PDF]

, 2019
BackgroundA single co-administered dose of ivermectin (IVM) plus diethylcarbamazine (DEC) plus albendazole (ALB), or triple-drug therapy, was recently found to be more effective for clearing microfilariae (Mf) than standard DEC plus ALB currently used ...
Bjerum, Catherine M, Chhonker, Yashpal S, Edi, Constant, King, Christopher L, Koudou, Benjamin G, Meite, Aboulaye, Murry, Daryl J, Ouattara, Allassane F, Penali, Louis K, Weil, Gary J   +9 more
core   +3 more sources

Boron-Pleuromutilins as Anti-Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis

Journal of Medicinal Chemistry, 2019
A series of pleuromutilins modified by introduction of a boron-containing heterocycle on C(14) of the polycyclic core are described. These analogs were found to be potent anti-Wolbachia antibiotics and, as such, may be useful in the treatment of filarial
R. Jacobs, C. Lunde, Y. Freund, Vincent Hernández, Xianfeng Li, Yi Xia, D. S. Carter, P. Berry, J. Halladay, F. Rock, Rianna Stefanakis, E. Easom, J. Plattner, L. Ford, K. Johnston, Darren Cook, R. Clare, A. Cassidy, Laura J. Myhill, Hayley E. Tyrer, Joanne Gamble, Ana F Guimaraes, A. Steven, F. Lenz, Alexandra Ehrens, Stefan J. Frohberger, Marianne Koschel, A. Hoerauf, M. Hübner, C. McNamara, M. Bakowski, J. Turner, M. Taylor, S. Ward   +33 more
semanticscholar   +1 more source

Infectious disease responses to human climate change adaptations

Global Change Biology, Volume 30, Issue 8, August 2024.
Climate change directly affects infectious diseases, but human adaptations—such as changes in water and food production, shifts in movement and habitats, and greenhouse gas reduction efforts—also influence disease spread. This paper examines how these responses can either increase or decrease disease risks.
Georgia Titcomb, Johnny Uelmen, Mark Janko, Charles Nunn   +3 more
wiley   +1 more source

An estimate of the prevalence of epilepsy in Sub-Saharan Africa:A systematic analysis [PDF]

, 2012
Epilepsy is a leading serious neurological condition worldwide and has particularly significant physical, economic and social consequences in Sub–Saharan Africa.
Adeloye, Davies, Chan, Kit Yee, George-Carey, Rhiannon, Grant, Elizabeth, Kolčić, Ivana, Paul, Abigail   +5 more
core   +2 more sources

Integrating eye care into primary healthcare in Nigeria: Challenges of the primary healthcare workforce

Public Health Challenges, Volume 3, Issue 2, June 2024.
Abstract Visual impairment and blindness pose a significant and growing public health threat in Nigeria. Over 1.6 million Nigerians are visually impaired or blind, with more than 80% of these cases being preventable and treatable. The risk for ocular morbidities is expected to increase due to rapid population growth, an aging population, and the rising
Bet‐ini Nsikak Christian, Deborah Oluwaseun Shomuyiwa, Nsikak Godwin Christian, Ntiense Raphael Umoette   +3 more
wiley   +1 more source

Would ivermectin for malaria control be beneficial in onchocerciasis-endemic regions?

Infectious Diseases of Poverty, 2019
Background There is accumulating evidence supporting the use of ivermectin as a malaria control tool. Recent findings from the repeat ivermectin mass drug administrations for control of malaria trial demonstrated a reduced incidence of malaria in ...
Joseph Nelson Siewe Fodjo, Marina Kugler, An Hotterbeekx, Adam Hendy, Jean-Pierre Van Geertruyden, Robert Colebunders   +5 more
doaj   +1 more source

Progress toward elimination of onchocerciasis in the Americas.

International Health, 2018
The Onchocerciasis Elimination Program for the Americas (OEPA) is a regional initiative and international partnership that has made considerable progress toward its goal since it was launched in 1993.
M. Sauerbrey, Lindsay J. Rakers, F. Richards   +2 more
semanticscholar   +1 more source

Synthesizing environmental, epidemiological and vector and parasite genetic data to assist decision making for disease elimination

Molecular Ecology, Volume 33, Issue 11, June 2024.
Abstract We present a framework for identifying when conditions are favourable for transmission of vector‐borne diseases between communities by incorporating predicted disease prevalence mapping with landscape analysis of sociological, environmental and host/parasite genetic data.
Himal Shrestha, Karen McCulloch, Rebecca H. Chisholm, Samuel K. Armoo, Francis Veriegh, Neha Sirwani, Katie E. Crawford, Mike Y. Osei‐Atweneboana, Warwick N. Grant, Shannon M. Hedtke   +9 more
wiley   +1 more source

Estimation of changes in the force of infection for intestinal and urogenital schistosomiasis in countries with Schistosomiasis Control Initiative-assisted programmes [PDF]

, 2015
The last decade has seen an expansion of national schistosomiasis control programmes in Africa based on large-scale preventative chemotherapy. In many areas this has resulted in considerable reductions in infection and morbidity levels in treated ...
A Garba, AD Barbour, AD Barbour, AJ Fulford, AJ Fulford, Alan Fenwick, Amadou Garba, AP Plaisier, AP Plaisier, ARC Harris, AW Cheever, B Bolker, B Payet, BL Webster, BL Webster, BL Webster, BR Kirkwood, CH King, CH King, D Engels, D Gurarie, DL Smith, E Michael, E Miguel, EK N'Goran, Elisa Bosqué-Oliva, Fiona M. Fleming, G Webbe, GA Macdonald, GE Box, GF Medley, H Laamrani, H Tanaka, Hairston NG, HC Turner, HC Turner, HP Duerr, I Nåsell, I Nåsell, J Utzinger, J Utzinger, James Mwansa, JH Ouma, Joanne P. Webster, JP Webster, JW Rudge, JW Rudge, L Van Etten, LA Tchuem-Tchuenté, LA Tchuem-Tchuenté, Lynsey Blair, M Booth, M Parker, M Tanner, M-G Basáñez, M-G Basáñez, Maria-Gloria Basáñez, ME Woolhouse, Michael D. French, ML Steinauer, Moussa Sacko, MS Chan, MS Chan, MS Chan, N Katz, Narcis B. Kabatereine, NB Kabatereine, NG Hairston, RM Anderson, RM Anderson, RM Anderson, RM Anderson, RM May, Seydou Toure, SJ de Vlas, SM Blower, Team" RDC, Thomas S. Churcher, Ursuline Nyandindi, WHO   +79 more
core   +3 more sources

Treatment and prevention of epilepsy in onchocerciasis-endemic areas is urgently needed

Infectious Diseases of Poverty
Background There is increasing epidemiological evidence supporting the association between onchocerciasis and seizures, reinforcing the concept of onchocerciasis-associated epilepsy (OAE).
Robert Colebunders, Joseph Nelson Siewe Fodjo, Olivia Kamoen, Luís-Jorge Amaral, Amber Hadermann, Chiara Trevisan, Mark J. Taylor, Julia Gauglitz, Achim Hoerauf, Yasuaki Sato, Katja Polman, María-Gloria Basáñez, Dan Bhwana, Thomson Lakwo, Gasim Abd-Elfarag, Sébastien D. Pion   +15 more
doaj   +1 more source