Results 141 to 150 of about 846,916 (323)

FBXO44 Regulates FOXP1 Degradation Through AURKA‐Dependent Phosphorylation to Promote Colorectal Cancer Progression

Advanced Science, EarlyView.
FBXO44 promotes colorectal cancer progression by targeting FOXP1 for ubiquitin‐mediated degradation. This study reveals a phosphorylation‐dependent mechanism involving AURKA and highlights the FBXO44/FOXP1/Cyclin E2 axis as a potential therapeutic target in colorectal cancer.
Hongxu Nie, Hengjie Xu, Sheng Yang, Chuanxin Tian, Tuo Wang, Chi Jin, Zhihao Chen, Xiaowei Wang, Junwei Tang, Yifei Feng, Yueming Sun   +10 more
wiley   +1 more source

p53: oncogene or anti-oncogene? [PDF]

Genes & Development, 1990
D P, Lane, S, Benchimol
openaire   +3 more sources

Heterogeneous cancer-associated fibroblast population potentiates neuroendocrine differentiation and castrate resistance in a CD105-dependent manner. [PDF]

, 2019
Heterogeneous prostatic carcinoma-associated fibroblasts (CAF) contribute to tumor progression and resistance to androgen signaling deprivation therapy (ADT).
Agarwal, Priyanka, Angara, Bryan, Bhowmick, Neil A, Billet, Sandrine, Duong, Frank, Haldar, Subhash, Hickok, David, Kato, Manabu, Liu, Zhenqiu, Madhav, Anisha, Mishra, Rajeev, Placencio-Hickok, Veronica R, Rohena-Rivera, Krizia, Smith, Bethany, Tripathi, Manisha   +14 more
core   +1 more source

Obesity‐Associated TRIM15 Promotes the Proliferation of Esophageal Adenocarcinoma Through the YY2/FOXRED1 Axis

Advanced Science, EarlyView.
The study identifies TRIM15 as a key driver in the development of obesity‐associated esophageal adenocarcinoma (EAC). Mechanistically, TRIM15 degrades YY2 through the proteasome pathway, suppressing FOXRED1 transcription and ultimately accelerating tumor proliferation.
Haohui Wang, Chong Yang, Dayuan Luo, Pingting Liu, Zhen Zeng, Weilin Peng, Dongzi Peng, Hao Su, Xiaoxiong Xiao, Haiqin Wang, Xin Jin   +10 more
wiley   +1 more source

Association Between Genetic Variant in the pre-miR-27a Oncogene and Risk of Breast Cancer and Metastasis

Journal of Mazandaran University of Medical Sciences, 2017
Background and purpose: Single-nucleotide polymorphisms (SNPs) within miRNA genes may be related with risk of cancer. A main SNP in the pre-miR-27a (rs895819) with an A to G variation was earlier identified.
Bentolhoda Shekari, Somayeh Reiisi
doaj  

Oncogenic mutant KRAS inhibition through oxidation at cysteine 118

Molecular Oncology
Specific reactive oxygen species activate the GTPase Kirsten rat sarcoma virus (KRAS) by reacting with cysteine 118 (C118), leading to an electron transfer between C118 and nucleoside guanosine diphosphate (GDP), which causes the release of GDP. Here, we
Maximilian Kramer‐Drauberg, Ettore Petrini, Alessia Mira, Enrico Patrucco, Rossella Scardaci, Ilenia Savinelli, Haiyun Wang, Keying Qiao, Giovanna Carrà, Marie‐Julie Nokin, Zhiwei Zhou, Kenneth D. Westover, David Santamaria, Paolo E. Porporato, Chiara Ambrogio   +14 more
doaj   +1 more source

LncRNA EIF3J-AS1 functions as an oncogene by regulating MAFG to promote prostate cancer progression [PDF]

, 2021
Chen Ye, Shengfei Qin, Fei Guo, Yue Yang, Huiqing Wang, Chao Zhang, Bo Yang   +6 more
openalex   +1 more source

DKK3 Initially Preserves Acinar Integrity Through MEK‐Fos Signaling, but Later Switches to an Oncogenic Role in Pancreatic Cancer

Advanced Science, EarlyView.
In pancreatic cancer, the protein DKK3 is found to play a complex role: it initially slows early tumor growth but later promotes tumor aggressiveness. DKK3 expression evolves during progression and drives cancer severity by orchestrating cellular and molecular signaling pathways.
Dharini Srinivasan, Elodie Roger, Lukas Perkhofer, Eleni Zimmer, Thomas F.E. Barth, Julia P. Mosler, Anna Härle, Stephanie E. Weissinger, Nadine T. Gaisa, Peter Möller, Nico Fischer, Chantal Allgöwer, J.‐Matthias Löhr, Dirk Grimm, Thomas Seufferlein, Stefan Liebau, Ninel Azoitei, Michael K. Melzer, Frank Arnold, Johann Gout, Alexander Kleger   +20 more
wiley   +1 more source

Advances and Challenges in Targeting TGF-β Isoforms for Therapeutic Intervention of Cancer: A Mechanism-Based Perspective

Pharmaceuticals
The TGF-β family is a group of 25 kDa secretory cytokines, in mammals consisting of three dimeric isoforms (TGF-βs 1, 2, and 3), each encoded on a separate gene with unique regulatory elements.
David Danielpour
doaj   +1 more source

Viral Oncogene Protein [PDF]

, 2020
National Cancer Institute
openalex   +1 more source