Results 161 to 170 of about 577,954 (290)

CRISPR/CAS9-based gene editing in cancer therapy: A systematic review and meta-analysis on current status and future directions. [PDF]

Medicine (Baltimore)
Rehman SU, Abbas GH.
europepmc   +1 more source

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

A prospective, multicenter, comprehensive genomic profile signature study in patients with EGFR-mutant advanced non-small cell lung cancer at the first-line treatment failure of osimertinib. [PDF]

Signal Transduct Target Ther
Shi Y, Lv D, Feng W, Liu S, Xing P, Yu Y, Yin J, Ren X, Zhang J, Han G, Zhang Y, Cang S, Chen J, Chen E, Meng L, Zhang Y.   +15 more
europepmc   +1 more source

microRNA‑572 functions as an oncogene and a potential biomarker for renal cell carcinoma prognosis

, 2018
Xiang Pan, Zuwei Li, Liwen Zhao, Jing Quan, Liang Zhou, Jinling Xu, XU Wei-ji, Xin Guan, Hang Li, Shangqi Yang, Yaoting Gui, Yongqing Lai   +11 more
openalex   +2 more sources

Small Nucleolar RNA Snord17 Promotes Self‐Renewal of Intestinal Stem Cells through Yy2 mRNA Export and Tead4 Activation

Advanced Science, EarlyView.
Snord17, through interaction with Thoc3, promotes nuclear export and translation of Yy2 mRNA in Snord17+/+ ISCs. The Yy2 protein subsequently binds the Tead4 promoter to promote its transcription, activating Hippo signaling, which is essential for ISC maintenance.
Peikang Zhang, Yuwei Xu, Yufei Lan, Zhen Xiong, Zhibin Yi, Runyuan Wu, Cunzhen Li, Ying Du, Hui Guo, Yingchi Yang, Zusen Fan   +10 more
wiley   +1 more source

Editorial Expression of Concern: Alterations in candidate genes PHF2, FANCC, PTCH1 and XPA at chromosomal 9q22.3 region: Pathological significance in early- and late-onset breast carcinoma

Molecular Cancer
Satyabrata Sinha, Ratnesh K. Singh, Neyaz Alam, Anup Roy, Susanta Roychoudhury, Chinmay Kumar Panda   +5 more
doaj   +1 more source

Clinical Significance of MYBL2 Expression in Hepatocellular Carcinoma: Impact on Overall Survival. [PDF]

Onco Targets Ther
Chen CC, Wei CT, Hsuan CF, Yu TH, Hung WC, Wu CC, Lee TL, Tang WH, Chung FM, Lee YJ, Hsu CC.   +10 more
europepmc   +1 more source

Extrachromosomal DNA driven oncogene spatial heterogeneity and evolution in glioblastoma [PDF]

Imran Noorani, Magnus Haughey, Jens Luebeck, Andrew Rowan, Eva Grönroos, Francesco Terenzi, Ivy Tsz-Lo Wong, Jeanette Kittel, Chris Bailey, Clare E. Weeden, Donald M. Bell, Jihoon E. Joo, Vittorio Barbè, Matthew G. Jones, Emma Nye, Mary Green, Lucy Meader, Emma Norton, Mark Fabian, Nnennaya Kanu, Mariam Jamal‐Hanjani, Thomas Santarius, James A. R. Nicoll, Delphine Boche, Howard Y. Chang, Vineet Bafna, Weini Huang, Paul S. Mischel, Charles Swanton, Benjamin Werner   +29 more
openalex   +1 more source

Next-generation sequencing analysis of receptor-type tyrosine kinase genes in surgically resected colon cancer: identification of gain-of-function mutations in the RET proto-oncogene [PDF]

, 2018
Duarte Mendes Oliveira, Katia Grillone, Chiara Mignogna, Valentina De Falco, Carmelo Laudanna, Flavia Biamonte, Rosa Locane, Francesco Corcione, Massimiliano Fabozzi, Rosario Sacco, Giuseppe Viglietto, Donatella Malanga, Antonia Rizzuto   +12 more
openalex   +1 more source

Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R‐Loop Accumulation and DNA Repair Deficiencies

Advanced Science, EarlyView.
ARID1A, a SWI/SNF complex component, is frequently mutated in colorectal cancer (CRC). CRC with ARID1A/TP53 concurrent mutations shows marked sensitivity to WEE1 inhibition. ARID1A loss induces R‐loop‐mediated replication stress, impairs ATF3 transcription, and amplifies WEE1i‐induced DNA damage, suggesting a promising therapeutic vulnerability ...
Chi Zhang, Yanjing Zhu, Luoyan Ai, Jingyuan Wang, Shan Yu, Yichen Wang, Xiaojing Xu, Mengling Liu, Yiyi Yu, Mengxuan Zhu, Yutong Liu, Zhenghang Xu, Haojie Zhou, Huishan Li, Qihong Huang, Qing Liu, Ke Peng, Tianshu Liu   +17 more
wiley   +1 more source