Results 181 to 190 of about 696,036 (402)

A 3D Genome Atlas of Genetic Variants and Their Pathological Effects in Cancer

Advanced Science, EarlyView.
The hierarchical organization of the eukaryotic genome is vital for nuclear function, and disruptions from genetic mutations can alter this 3D architecture. Cataloging thousands of interchromosomal translocations, structural variants, and single nucleotide polymorphisms, their impact on 3D genome organization is revealed. The scoring algorithm, 3DFunc,
Li Tang, Matthew C. Hill, Mingxing He, Junhao Chen, Zirui Wang, Patrick T. Ellinor, Min Li   +6 more
wiley   +1 more source

H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen.

, 1988
Ivan E. Collier, S M Wilhelm, Arthur Z. Eisen, Barry L. Marmer, Gregory A. Grant, Jo Louise Seltzer, Annemarie Kronberger, C S He, Eugene A. Bauer, Gregory I. Goldberg   +9 more
openalex   +1 more source

Sequence, topography and protein coding potential of mouse int-2: a putative oncogene activated by mouse mammary tumour virus. [PDF]

, 1986
Robert J. Moore, G. Casey, Sharon Brookes, Mark S. Dixon, Godefridus J. Peters, Clive Dickson   +5 more
openalex   +1 more source

Circular ecDNA promotes accessible chromatin and high oncogene expression

Nature, 2019
Sihan Wu, Kristen M. Turner, Nam Nguyen, R. Raviram, M. Erb, J. Santini, J. Luebeck, Utkrisht Rajkumar, Yarui Diao, Yarui Diao, Bin Li, Wenjing Zhang, Nathan M. Jameson, M. Corces, Jeffrey M. Granja, Xingqi Chen, Xingqi Chen, C. Coruh, Armen Abnousi, Jack Houston, Z. Ye, Rong Hu, Miao Yu, Hoon Kim, Julie A. Law, R. Verhaak, Ming Hu, F. Furnari, Howard Y. Chang, Howard Y. Chang, B. Ren, V. Bafna, P. Mischel   +32 more
semanticscholar   +1 more source

PCSK9 Promotes the Malignancy of Triple‐negative Breast Cancer Cells by Reducing Cholesterol Levels at the Plasma Membrane to Activate EGFR and HER3

Advanced Science, EarlyView.
By decreasing cholesterol and lipid raft levels in the plasma membrane, proprotein convertase subtilisin/kexin type 9 (PCSK9) boosts human epidermal growth factor receptor 1 and 3 (EGFR and HER3) activation, driving tumor growth and metastasis in triple‐negative breast cancer (TNBC).
Tianhong Li, Renfei Wu, Kathy Qian Luo
wiley   +1 more source

Evolutionary conserved close linkage of the c-fes/fps proto-oncogene and genetic sequences encoding a receptor-like protein. [PDF]

, 1986
Anton Roebroek, Jack A. Schalken, J.A.M. Leunissen, C. Onnekink, Henri P.J. Bloemers, W J Van de Ven   +5 more
openalex   +1 more source

DNA Origami‐Cyanine Nanocomplex for Precision Imaging of KRAS‐Mutant Pancreatic Cancer Cells

Advanced Science, EarlyView.
DNA origami‐cyanine (Do‐Cy) nanocomplexes are synthesized to selectively image KRAS‐mutant pancreatic cancer cells in the highly desmoplastic tumors. This study shows that the Do‐Cy nanocomplexes are preferentially internalized by cancer cells over other stroma cells via KRAS‐dependent macropinocytosis.
Hye‐ran Moon, Yancheng Du, Sae Rome Choi, Seongmin Seo, Cih Cheng, Bennett D. Elzey, Jong Hyun Choi, Bumsoo Han   +7 more
wiley   +1 more source

Translocation of an immunoglobulin kappa locus to a region 3' of an unrearranged c-myc oncogene enhances c-myc transcription. [PDF]

, 1983
Jan Erikson, Kazuko Nishikura, A ar-Rushdi, J Finan, Beverly S. Emanuel, Gilbert Lenoir, Peter C. Nowell̀, Carlo M. Croce   +7 more
openalex   +1 more source

CircRNA‐mTOR Promotes Hepatocellular Carcinoma Progression and Lenvatinib Resistance Through the PSIP1/c‐Myc Axis

Advanced Science, EarlyView.
This study verifies that circRNA‐mTOR exhibits high expression levels in HCC and has a strong correlation with patient prognosis. Mechanistically, circRNA‐mTOR achieves this effect by facilitating the nuclear translocation of RNA‐binding protein (RBP) PSIP1 through specific binding.
Yongchang Tang, Feng Yuan, Mingbo Cao, Yupeng Ren, Yuxuan Li, Gaoyuan Yang, Zhaozhong Zhong, Hao Liang, Zhiyong Xiong, Zhiwei He, Nan Lin, Meihai Deng, Zhicheng Yao   +12 more
wiley   +1 more source

The protein encoded by the human proto-oncogene c-myc.

, 1984
Gary Ramsay, Gérard I. Evan, J. Michael Bishop   +2 more
openalex   +1 more source