Results 191 to 200 of about 845,274 (281)

Supplementary Figure 5 from Oncogene <i>AEG-1</i> Promotes Glioma-Induced Neurodegeneration by Increasing Glutamate Excitotoxicity

, 2023
Seok‐Geun Lee, Kee‐Tae Kim, Timothy P. Kegelman, Rupesh Dash, Swadesh K. Das, Jung Kyoung Choi, Luni Emdad, Eric L. Howlett, Hyun Yong Jeon, Zhao Su, Byoung Kwon Yoo, Devanand Sarkar, Sung‐Hoon Kim, Dong‐Chul Kang, Paul B. Fisher   +14 more
openalex   +1 more source

The ITGB2‐COPS3‐SOX2 Axis and SOX2 Liquid‐Liquid Phase Separation: Dual Mechanisms Governing Osteosarcoma Stemness

Advanced Science, EarlyView.
Osteosarcoma stemness is driven by the ITGB2‐COPS3‐SOX2 signaling axis. This study reveals that nuclear COPS3 stabilizes SOX2, which in turn undergoes liquid‐liquid phase separation to promote stemness. Based on this mechanism, a novel COPS3 inhibitor, Z‐5891, was developed, effectively suppressing tumor growth and stemness in vivo, offering a ...
Lei Guo, Zhiqing Zhao, Wei Wang, Jianfang Niu, Bing Wang, Yunfei Lin, Wei Guo, Taiqiang Yan   +7 more
wiley   +1 more source

Comprehensive profiling of circRNAs reveals stimulus-specific networks and core regulators of cellular senescence. [PDF]

PLoS One
Ge M, Liu Z, Zhao X, Zhan X, Jiang S.
europepmc   +1 more source

Concordance and Discordance Rates of V-Raf Murine Sarcoma Viral Oncogene Homolog B1 (BRAF) ^V600E Status in Metastatic against Primary Lesion of Melanoma: A Meta-analysis

, 2020
Hiroshi Yokomichi, Takashi Inozume, Makoto Wada, Jun Asai, Hiroshi Igaki, Kenjiro Namikawa, Ayato Hayashi, Satoshi Fukushima, Taku Fujimura, Hiroshi Koga, Yasuhiro Nakamura, M. Mochizuki, Zentaro Yamagata   +12 more
openalex   +1 more source

Supplementary figure 2 from microRNA-221 Enhances MYCN via Targeting Nemo-like Kinase and Functions as an Oncogene Related to Poor Prognosis in Neuroblastoma

, 2023
Xiao-yan He, Zheng-lan Tan, Qin Mou, Fangjie Liu, Shan Liu, Chaowen Yu, Jin Zhu, Lin-ya Lv, Jun Zhang, Shan Wang, Liming Bao, Bin Peng, Hui Zhao, Lin Zou   +13 more
openalex   +1 more source

Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression

Advanced Science, EarlyView.
This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng, Shuang Cai, Chen Guo, Shaker Khan, Lefan Liu, Qiong Tian, Zhiyuan Ma, Jian Zhang, Lingyu Zhao   +8 more
wiley   +1 more source

[Retracted] 8‑bromo‑7‑methoxychrysin induces apoptosis by regulating Akt/FOXO3a pathway in cisplatin‑sensitive and resistant ovarian cancer cells [PDF]

Mol Med Rep
Ding Q, Chen Y, Zhang Q, Guo Y, Huang Z, Dai L, Cao S.   +6 more
europepmc   +1 more source

Editorial Expression of Concern: Alterations in candidate genes PHF2, FANCC, PTCH1 and XPA at chromosomal 9q22.3 region: Pathological significance in early- and late-onset breast carcinoma

Molecular Cancer
Satyabrata Sinha, Ratnesh K. Singh, Neyaz Alam, Anup Roy, Susanta Roychoudhury, Chinmay Kumar Panda   +5 more
doaj   +1 more source

Movie S1 from Rare but Recurrent ROS1 Fusions Resulting From Chromosome 6q22 Microdeletions are Targetable Oncogenes in Glioma

, 2023
Monika A. Davare, Jacob J. Henderson, Anupriya Agarwal, Jacob P. Wagner, Sudarshan R. Iyer, Nameeta Shah, Randy Woltjer, Romel Somwar, Stephen W. Gilheeney, Ana DeCarvalo, Tom Mikkelson, Erwin G. Van Meir, Marc Ladanyi, Brian Druker   +13 more
openalex   +1 more source

Dual Aptamers‐Based SETDB1 PROTACs as Effective Anti‐Tumor Strategies for Breast Cancer

Advanced Science, EarlyView.
This study establishes dual‐aptamer PROTACs targeting SETDB1 using a SETDB1‐specific aptamer conjugated to AS1411. The designed PROTACs penetrate cells, recruit MDM2 to degrade SETDB1, and inhibit cancer cell proliferation and migration. Remarkably, they also overcome tamoxifen resistance and enhance CD8+ T cell cytotoxicity, suppressing tumor growth ...
Yanxuan Guo, Yingge Lv, Shuyu Huang, Chang Liu, Yan Ouyang, Bei Lan, Chenghao Xuan   +6 more
wiley   +1 more source