Results 211 to 220 of about 571,490 (260)
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The Journal of Pathology, 1984
A barrage of information is now emerging about one of the thorniest and most significant problems in biology: the nature of the genetic events that trigger neoplasia. While the notion that cancer reflects somatic mutations is several decades old, only in the last few years could the relevant 'oncogenes' be identified and put to molecular dissection ...
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A barrage of information is now emerging about one of the thorniest and most significant problems in biology: the nature of the genetic events that trigger neoplasia. While the notion that cancer reflects somatic mutations is several decades old, only in the last few years could the relevant 'oncogenes' be identified and put to molecular dissection ...
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Journal of Cellular Physiology, 1983
The discovery that normal cells contain proto-oncogenes--genes that are analogous to known viral oncogenes--may provide a shortcut not only to understanding some of the pathophysiologic mechanisms that must be involved in carcinogenesis but also to dissecting the processes of normal cell growth and of the evolutionarily developed controls on such ...
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The discovery that normal cells contain proto-oncogenes--genes that are analogous to known viral oncogenes--may provide a shortcut not only to understanding some of the pathophysiologic mechanisms that must be involved in carcinogenesis but also to dissecting the processes of normal cell growth and of the evolutionarily developed controls on such ...
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Current Opinion in Cell Biology, 1990
The study of oncogenes offers insights into many steps in signal transduction. Rapid progress is possible because of the combination of biochemistry and genetics--unique in vertebrate cell biology--the availability of specific clones and antibodies, sequence information, dominant mutants, and biochemical assays of function.
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The study of oncogenes offers insights into many steps in signal transduction. Rapid progress is possible because of the combination of biochemistry and genetics--unique in vertebrate cell biology--the availability of specific clones and antibodies, sequence information, dominant mutants, and biochemical assays of function.
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Cancer Letters, 1988
Particular eukaryotic genes which play integral roles in the control of normal growth and differentiation programs are targets for mutagenic events which lead to the generation of malignancies. These genes, called proto-oncogenes can be activated to the oncogenic state by amplification, point mutation, deletion or chromosomal translocation. The protein
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Particular eukaryotic genes which play integral roles in the control of normal growth and differentiation programs are targets for mutagenic events which lead to the generation of malignancies. These genes, called proto-oncogenes can be activated to the oncogenic state by amplification, point mutation, deletion or chromosomal translocation. The protein
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Seminars in Musculoskeletal Radiology, 2002
Oncogenic osteomalacia is a rare paraneoplastic syndrome caused by bone and soft tissue tumors. The characteristic clinical, metabolic, and imaging findings are reviewed, as is the radiologist's role in evaluation and diagnosis. New insight into the pathophysiology of oncogenic osteomalacia is also presented.
Kelli Andresen, Edmister +1 more
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Oncogenic osteomalacia is a rare paraneoplastic syndrome caused by bone and soft tissue tumors. The characteristic clinical, metabolic, and imaging findings are reviewed, as is the radiologist's role in evaluation and diagnosis. New insight into the pathophysiology of oncogenic osteomalacia is also presented.
Kelli Andresen, Edmister +1 more
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The marriage of oncogenes and anti-oncogenes
Trends in Genetics, 1988One of the more gratifying trends in oncogene/growth factor research has been the recent convergence of many initially unconnected investi- gations. Studies of retroviral onco- genes and cellular growth factors have merged as many of these onco- genes have been found to be homolo- gous with genes for growth factors or growth factor receptors. Similarly,
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New England Journal of Medicine, 2008
This review — the first in a series concerning the biology of cancer — is a comprehensive survey of oncogenes, tumor-suppressor genes, and microRNA genes in cancer cells. Work on the recently discovered microRNA genes in malignant cells has revealed new complexities in the regulation of oncogenes and tumor-suppressor genes and new opportunities for the
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This review — the first in a series concerning the biology of cancer — is a comprehensive survey of oncogenes, tumor-suppressor genes, and microRNA genes in cancer cells. Work on the recently discovered microRNA genes in malignant cells has revealed new complexities in the regulation of oncogenes and tumor-suppressor genes and new opportunities for the
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1998
Virulent strains of Agrobacterium tumefaciens and Agrobacterium rhizogenes induce non-self limiting — neoplastic — growths on susceptible plants, generally in dicotyledonous species from the Angiosperms. In most cases, A. tumefaciens induces unorganized “crown gall” tumors (so named because the growths were often observed at the crown of the plant ...
BINNS A. N., COSTANTINO, Paolo
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Virulent strains of Agrobacterium tumefaciens and Agrobacterium rhizogenes induce non-self limiting — neoplastic — growths on susceptible plants, generally in dicotyledonous species from the Angiosperms. In most cases, A. tumefaciens induces unorganized “crown gall” tumors (so named because the growths were often observed at the crown of the plant ...
BINNS A. N., COSTANTINO, Paolo
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Oncogenes and proto-oncogenes: General concepts
1989Theoretically, the cancerous phenotype of cells can result from epigenetic or biochemical regulatory changes without alteration of the genotype. Although epigenetic changes may contribute to neoplasia, overwhelming evidence supports the concept that neoplasia results from heritable changes allowing unrestrained growth of cells that are associated with ...
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