Results 241 to 250 of about 826,474 (295)
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The Journal of Pathology, 1984
A barrage of information is now emerging about one of the thorniest and most significant problems in biology: the nature of the genetic events that trigger neoplasia. While the notion that cancer reflects somatic mutations is several decades old, only in the last few years could the relevant 'oncogenes' be identified and put to molecular dissection ...
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A barrage of information is now emerging about one of the thorniest and most significant problems in biology: the nature of the genetic events that trigger neoplasia. While the notion that cancer reflects somatic mutations is several decades old, only in the last few years could the relevant 'oncogenes' be identified and put to molecular dissection ...
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Journal of Cellular Physiology, 1983
The discovery that normal cells contain proto-oncogenes--genes that are analogous to known viral oncogenes--may provide a shortcut not only to understanding some of the pathophysiologic mechanisms that must be involved in carcinogenesis but also to dissecting the processes of normal cell growth and of the evolutionarily developed controls on such ...
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The discovery that normal cells contain proto-oncogenes--genes that are analogous to known viral oncogenes--may provide a shortcut not only to understanding some of the pathophysiologic mechanisms that must be involved in carcinogenesis but also to dissecting the processes of normal cell growth and of the evolutionarily developed controls on such ...
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Cancer Letters, 1988
Particular eukaryotic genes which play integral roles in the control of normal growth and differentiation programs are targets for mutagenic events which lead to the generation of malignancies. These genes, called proto-oncogenes can be activated to the oncogenic state by amplification, point mutation, deletion or chromosomal translocation. The protein
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Particular eukaryotic genes which play integral roles in the control of normal growth and differentiation programs are targets for mutagenic events which lead to the generation of malignancies. These genes, called proto-oncogenes can be activated to the oncogenic state by amplification, point mutation, deletion or chromosomal translocation. The protein
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Science, 2021
Melanoma can arise only from cells with a permissive chromatin ...
David W, Vredevoogd, Daniel S, Peeper
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Melanoma can arise only from cells with a permissive chromatin ...
David W, Vredevoogd, Daniel S, Peeper
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Seminars in Musculoskeletal Radiology, 2002
Oncogenic osteomalacia is a rare paraneoplastic syndrome caused by bone and soft tissue tumors. The characteristic clinical, metabolic, and imaging findings are reviewed, as is the radiologist's role in evaluation and diagnosis. New insight into the pathophysiology of oncogenic osteomalacia is also presented.
Kelli Andresen, Edmister +1 more
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Oncogenic osteomalacia is a rare paraneoplastic syndrome caused by bone and soft tissue tumors. The characteristic clinical, metabolic, and imaging findings are reviewed, as is the radiologist's role in evaluation and diagnosis. New insight into the pathophysiology of oncogenic osteomalacia is also presented.
Kelli Andresen, Edmister +1 more
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Human Genetics, 1984
The information published on human oncogenes up to the fall of 1983 is reviewed. Retroviral oncogenes, proto-oncogenes, and cellular transforming genes are compared. Transforming genes derived from the ras gene family are described in detail. The different mechanisms of activation of proto-oncogenes are summarized.
K, Willecke, R, Schäfer
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The information published on human oncogenes up to the fall of 1983 is reviewed. Retroviral oncogenes, proto-oncogenes, and cellular transforming genes are compared. Transforming genes derived from the ras gene family are described in detail. The different mechanisms of activation of proto-oncogenes are summarized.
K, Willecke, R, Schäfer
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Cancer, 1993
Tumor-suppressor genes (antioncogenes or recessive oncogenes) are cancer genes that achieve their oncogenic effect by mutational inactivation of both normal alleles. By contrast, oncogenes are created from protooncogenes by mutations that lead to aberrant functional activation. Mutation of multiple suppressor genes and/or oncogenes probably is required
R, Bookstein, D C, Allred
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Tumor-suppressor genes (antioncogenes or recessive oncogenes) are cancer genes that achieve their oncogenic effect by mutational inactivation of both normal alleles. By contrast, oncogenes are created from protooncogenes by mutations that lead to aberrant functional activation. Mutation of multiple suppressor genes and/or oncogenes probably is required
R, Bookstein, D C, Allred
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