Results 251 to 260 of about 617,669 (345)
The role of splicing factor 3A subunit 3 (SF3A3) in driving endometrial cancer (EC) progression and potential therapeutic interventions. SF3A3, a core component of the U2 small nuclear ribonucleoprotein (U2 snRNP), is upregulated in endometrial cancer (EC) and promotes tumor growth and cisplatin resistance. RNA‐binding protein immunoprecipitation (RIP)
Wei Yu+13 more
wiley +1 more source
CircRNAs: a novel potential strategy to treat breast cancer. [PDF]
Chen P+6 more
europepmc +1 more source
TMCO3 as a downstream target of ALKBH5 is found, which regulates its expression in an m6A‐dependent manner, and then a new phosphorylation site on TMCO3 is identified and determines the specific mechanism of TMCO3 with AKT. Moreover, the combined treatment of targeting the TMCO3 and inhibition of AKT in mice models with HCC achieves great results ...
Xinxin Li+8 more
wiley +1 more source
Correction: FTO downregulation mediated by hypoxia facilitates colorectal cancer metastasis. [PDF]
Ruan DY+16 more
europepmc +1 more source
KRAS/ABHD17C/ALOX15B Axis Promotes Pancreatic Cancer Progression via Ferroptosis Evasion
Phosphorylation of ABHD17C induced by KRASmut/ERK signaling facilitates ALOX15B depalmitoylation and degradation via the CUL4/DDB1/DCAF10 complex, thereby enabling KRASmut‐PDAC cell to evade ferroptosis. Methyl protodioscin inhibits KRASmut‐PDAC progression by disrupting the ABHD17C/ALOX15B interaction and inducing ferroptosis, which represents a ...
Man Li+12 more
wiley +1 more source
Utility of combined solid and liquid biopsy for molecular profiling in lung adenocarcinoma: Insights from a real-world case. [PDF]
Bhosale B+14 more
europepmc +1 more source
A Feedback Loop Between Fatty Acid Metabolism and Epigenetics in Clear Cell Renal Carcinoma
The current study has profiled the landscape of active enhancers in ccRCC and identified FABP5 as an oncogene. FABP5 is essential for the lipid droplet formation driven by HIFs and critical for H3K27ac and enhancer activity. The study has discovered the function of a feedback loop between epigenetics and lipid metabolism regulated by FABP5 in ccRCC ...
Zhou Ye+21 more
wiley +1 more source
Research progress on m6A and drug resistance in gastrointestinal tumors. [PDF]
Xu Z+6 more
europepmc +1 more source
DSBs are the most critical genomic lesions. Using the ChromInSight framework, It is revealed that 3D chromatin structure, rather than linear distance, shapes cluster‐scene between hub‐Nodes and DSB loci. The “spatial isolation–damage containment” hypothesis is proposed to illustrate how the genome responds to genomic damage and offer a powerful tool ...
Kang Xu+9 more
wiley +1 more source