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Oncogenes and proto-oncogenes: General concepts
1989Theoretically, the cancerous phenotype of cells can result from epigenetic or biochemical regulatory changes without alteration of the genotype. Although epigenetic changes may contribute to neoplasia, overwhelming evidence supports the concept that neoplasia results from heritable changes allowing unrestrained growth of cells that are associated with ...
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Rheumatology, 1989
Rheumatoid arthritis (RA) is probably an auto-immune disorder incited by an infectious insult or primary disorder of the immune system. A viral aetiology is particularly attractive, as not only do we have documented virally associated arthritides in humans, e.g. rubella, Epstein-Barr virus and parvovirus, but also a member of the lentivirus subgroup of
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Rheumatoid arthritis (RA) is probably an auto-immune disorder incited by an infectious insult or primary disorder of the immune system. A viral aetiology is particularly attractive, as not only do we have documented virally associated arthritides in humans, e.g. rubella, Epstein-Barr virus and parvovirus, but also a member of the lentivirus subgroup of
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American Journal of Reproductive Immunology and Microbiology, 1987
ABSTRACT: Early studies designed to investigate the molecular basis of oncogenesis indicated the existence of discrete genes which could cause neoplastic transformation of normal cells in vitro. These genes (which became known as oncogenes) were originally thought to be derived from oncogenic retroviruses and neoplastic transformation was believed to ...
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ABSTRACT: Early studies designed to investigate the molecular basis of oncogenesis indicated the existence of discrete genes which could cause neoplastic transformation of normal cells in vitro. These genes (which became known as oncogenes) were originally thought to be derived from oncogenic retroviruses and neoplastic transformation was believed to ...
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1985
Publisher Summary Oncogenes are a set of cellular and viral genes that induce morphologic transformation and/or neoplastic changes in cells in which they are either activated or introduced in activated form. Their oncogenic properties are defined by the particular cells and biological test systems that are used to detect their presence.
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Publisher Summary Oncogenes are a set of cellular and viral genes that induce morphologic transformation and/or neoplastic changes in cells in which they are either activated or introduced in activated form. Their oncogenic properties are defined by the particular cells and biological test systems that are used to detect their presence.
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Targeting oncogene and non-oncogene addiction to inflame the tumour microenvironment
Nature Reviews Drug Discovery, 2022Giulia Petroni +2 more
exaly
ecDNA hubs drive cooperative intermolecular oncogene expression
Nature, 2021Joshua T Lange +2 more
exaly
1992
Publisher Summary This chapter focuses on the characterization and mode of action of oncogenes. The chapter presents several theories affiliated with carcinogenesis and basic techniques that are used for the study of oncogenes responsible for cancer. Some peculiarities of the carcinogenic process may be explained in terms of sequential activation of ...
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Publisher Summary This chapter focuses on the characterization and mode of action of oncogenes. The chapter presents several theories affiliated with carcinogenesis and basic techniques that are used for the study of oncogenes responsible for cancer. Some peculiarities of the carcinogenic process may be explained in terms of sequential activation of ...
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Oncogenes and oncogenic viruses
Indian Journal of Clinical Biochemistry, 1996openaire +2 more sources