Results 161 to 170 of about 369,580 (326)

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

Advanced extracellular vesicle immunotherapy

FlexMat, EarlyView.
A diagrammatic depiction of the therapeutic applicability of extracellular vesicles (EVs) in immunotherapy. This review explores the dual roles of tumor‐derived and immune cell‐derived EVs in cancer immunotherapy, discusses recent progress in EV engineering that improve their clinical utility, and evaluates their potential to augment existing ...
Jingjing Zhang, Yunfei Mu, Xianyue Ji, Xiaoting Jiang, Ruiheng Wang, Xianguang Ding, Lianhui Wang   +6 more
wiley   +1 more source

Nucleophosmin-anaplastic lymphoma kinase: the ultimate oncogene and therapeutic target.

Blood, 2017
Michael T. Werner, Chen Zhao, Qian Zhang, M. Wasik   +3 more
semanticscholar   +1 more source

AML1-ETO oncogenic fusion protein [PDF]

Science-Business eXchange, 2010
openaire   +1 more source

Self-assembled Human Serum Protein-based Core-shell Nanoparticles to inhibit key oncogenic signalling in Drug-Resistant Leukemia

Precision Nanomedicine
Simultaneous inhibition of multiple oncogenic signaling pathways is crucial for managing refractory cancers. This study introduces two unique core-shell nanoparticle (CS-NP) systems crafted from natural proteins that simultaneously target two crucial ...
Archana Payickattu Retnakumary, Lekshmi G Kumar, Neeraj Sidharthan, Pavithran Keechilat, Giridharan L. Malarvizhi, Prasanna L Hanumanthu, Madhavan V Thampi, Deepthy Menon, Krishnakumar Menon, Shantikumar V Nair, Manzoor Koyakutty   +10 more
doaj   +1 more source

Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene

Molecular and Cellular Biology, 1992
Marieke, Von, Lindern, Sjozef, van, Baal, J. Wiegant, A. Raap, A. Hagemeijer, Gerard GROSVELDl   +9 more
semanticscholar   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

BCR/ABL leukemia oncogene fusion peptides selectively bind to certain HLA-DR alleles and can be recognized by T cells found at low frequency in the repertoire of normal donors.

Blood, 1996
Graham Pawelec, H. Max, T. Halder, O. Bruserud, A. Merl, P. D. Silva, Hubert Kalbacher   +6 more
semanticscholar   +1 more source

Ret proto-oncogene (RET); KIF5B-RET oncogenic fusion protein [PDF]

Science-Business eXchange, 2012
openaire   +1 more source

Tumorigenesis in mice with a fusion of the leukaemia oncogene Mll and the bacterial lacZ gene

EMBO Journal, 2000
C. Dobson, A. Warren, R. Pannell, A. Forster, T. Rabbitts   +4 more
semanticscholar   +1 more source