Results 241 to 250 of about 103,602 (308)

Spatiotemporal dynamics of β‐arrestin‐mediated Src activation in 5‐HT7 receptor signaling pathway

The FEBS Journal, EarlyView.
GPCRs induce distinct cellular responses via G protein‐ or β‐arrestin‐mediated signaling pathways. This study revealed that β‐arrestin‐biased 5‐HT7R ligand induces slow, sustained Src activation, contrasting with transient G protein‐mediated activation.
Hyunbin Kim, Yong Woo Lee, Huimin Lee, Eunseo Park, Jieon Lee, Hae Nim Lee, Kyeong‐Man Kim, Hyunah Choo, Jihye Seong   +8 more
wiley   +1 more source

Ras oncogene and deregulation of differentiation in thyroid cells

, 2009
Baratta, Maria Giuseppina
core  

FusionTarget: Computational framework for drug repurposing against modeled fusion protein structures from genomic breakpoints. [PDF]

iScience
Kumar H, Tsang SV, Lee MS, Huang YH, Choi J, Lotlikar SR, Song JY, Toh A, Choi YL, Brannan KW, Kim P.   +10 more
europepmc   +1 more source

Mitochondrial transfer in acute myeloid leukaemia and multiple myeloma: Mechanisms, consequences and potential therapeutic opportunities

The FEBS Journal, EarlyView.
Mitochondria can be transferred from bone marrow cells to cancer cells in acute myeloid leukaemia and multiple myeloma, boosting tumour energy production, growth, and drug resistance. This review highlights key transfer mechanisms and shows how targeting mitochondrial movement and dynamics may offer new therapeutic strategies to limit cancer ...
Ebubechukwu Nwarunma, Mark T. S. Williams   +1 more
wiley   +1 more source

Novel <i>MYH11::GLI3</i> fusion in ileal leiomyoma. [PDF]

Pathol Oncol Res
Panagopoulos I, Lobmaier I.
europepmc   +1 more source

Salt glands in exo‐recretohalophytes: Development, physiological functions, and prospects for improving crop salt tolerance

Journal of Integrative Plant Biology, EarlyView.
This review examines salt glands in exo‐recretohalophytes, in which epidermal stem cells differentiate into unicellular, bicellular, or multicellular salt glands. Salt ions are transported to the leaves via the transpiration stream and enter salt glands through symplastic and apoplastic pathways. Finally, salt glands actively secrete salt ions from the
Limin Wang, Junyan Xie, Yiping Zou, Chunliang Yao, Hai Fan, Chenqi Shen, Wenyan Zhou, Jingran Qin, Xinke Zhang, Baoshan Wang, Jian Zhang, Guoliang Han   +11 more
wiley   +1 more source

CUX1::MET fusion defines an indolent subtype of diffuse low-grade glioma, MAPK pathway-altered. [PDF]

Acta Neuropathol Commun
Nagashima H, Takeuchi Y, Jimbo N, Matsuda H, Kimbara S, Tanaka K, Sasayama T.   +6 more
europepmc   +1 more source

Genomic variation drives plant flavor diversification

Journal of Integrative Plant Biology, EarlyView.
This review explains how genomic variation shapes plant flavor by altering the biosynthetic and regulatory pathways of key attributes like sweetness, acidity, bitterness, piquancy, astringency, and aroma. It also discusses how multi‐omics, AI‐assisted breeding, and gene editing can translate this knowledge into plants with improved flavor, nutrition ...
Huimin Hu, Yanwei Hao, Yiwei Zhou, Xia Zhang, Rui Xia, Pan Liao   +5 more
wiley   +1 more source

Diffuse pediatric-type high grade glioma, RTK1 subtype, subclass C with <i>SYN2</i>::<i>PPARG</i> fusion in an older adult. [PDF]

CNS Oncol
Brentlinger MN, Patel J, Khan A, Castro-Echeverry E, Abdullaev Z, Aldape K, Lehman NL.   +6 more
europepmc   +1 more source

Fusion oncogenes in cancer: organoid models and novel therapeutic approaches. [PDF]

BMC Biol
Bracesco L, Hendriks D, Artegiani B.
europepmc   +1 more source