Results 251 to 260 of about 103,602 (308)

From senescence and inflammaging to systemic comorbidities: Drivers of aging‐associated periodontitis

Periodontology 2000, EarlyView.
Abstract Background Aging is accompanied by a chronic low‐grade inflammatory process, known as inflammaging, as well as immunosenescence, an age‐related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro‐inflammatory factors.
James Cheng, Chew Tin Zar Aung, Samuel F. Suslavich, Sinem Esra Sahingur, Yvonne L. Hernandez‐Kapila   +4 more
wiley   +1 more source

RNA-based precision medicine in glioblastoma driven by oncogenic gene fusions. [PDF]

Mol Ther Oncol
Bouillon M, Lapoujade C, Basset L, Fontaine A, Hollenstein M, Garcion E, Rousseau A.   +6 more
europepmc   +1 more source

Integrative Phosphoproteomic Profiling Reveals Stage‐Specific Signalling and Metabolism in Equine Melanocytic Neoplasm

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Equine melanocytic neoplasms (EMN) are aggressive tumours characterised by high metastatic potential and limited therapeutic options available. However, the molecular mechanisms underlying their progression remain poorly understood. This study therefore presents the integrative phosphoproteomic analysis of EMN tissue, with the aim of ...
Paitoon Srimontri, Amornthep Kingkaw, Nawarus Prapaiwan, Rangsima Sujittosakul, Nichapat Iamkaewprasert, Jiraschaya Piputwat, Puetta Isama‐al, Thanutchanok Munkongdee, Thanapon Chotikaprakal, Petchpailin Yanyongsirikarn, Narumon Phaonakrop, Sittiruk Roytrakul, Wanwipa Vongsangnak, Parichart Tesena   +13 more
wiley   +1 more source

Knockout of Mucin 1 inhibits the proliferation, migration, and invasion of human MDA-MB-231 cells by blocking autophagy flow. [PDF]

Braz J Med Biol Res
Huang Z, Zhao J, Zhang Q, Luo Y, Chen W, Liu Z, Liu X.   +6 more
europepmc   +1 more source

Tumor‐educated platelets in cancer diagnostics and prognostics: A critical appraisal and roadmap for clinical translation

International Journal of Cancer, Volume 159, Issue 2, Page 302-319, 15 July 2026.
Abstract Tumor‐educated platelets (TEPs) are emerging as a compelling frontier in liquid biopsy, functioning as dynamic, systemic sensors that sequester and process tumor‐derived biomolecules. This interaction imprints an integrated molecular signature of malignancy—spanning the transcriptome, proteome, lipidome, and crucially, the captured genome ...
Whi‐An Kwon, Min‐Kyung Lee, Eunyong Ahn, Heeyeon Kim, Yong Sang Song, Taejin Ahn   +5 more
wiley   +1 more source

The oncogenic role of ecotropic viral integration site 1 in hematological malignancies: mechanisms of activation and leukemogenesis. [PDF]

Front Immunol
Hao Y, Liu J, Lou J, Yan J.
europepmc   +1 more source

Dissecting Pirtobrutinib Resistance in Mantle Cell Lymphoma Through Single‐Cell Multi‐Omics

American Journal of Hematology, Volume 101, Issue 7, Page 1632-1649, July 2026.
ABSTRACT Pirtobrutinib (PBN), a non‐covalent BTK inhibitor, has been approved by the FDA for relapsed/refractory mantle cell lymphoma (MCL); however, resistance to PBN has been observed. To dissect the molecular dynamics driving PBN resistance, we performed integrative single‐cell multi‐omic profiling (scRNA‐seq, scATAC‐seq, and scDNA‐seq) on ...
Fangfang Yan, Yang Liu, Heng‐Huan Lee, Wei Wang, Joseph McIntosh, Yijing Li, Jovanny Vargas, Yue Fei, Sairah Ahmed, Lukas M. Simon, Michael Wang   +10 more
wiley   +1 more source

Temperature and lipid composition differentially regulate KRAS assemblies on membranes.

Chem Commun (Camb)
Kang J, Scott E, Yun SD, James VK, Chang JY, Bahramimoghaddam H, Downing J, Evans K, Russell DH, Laganowsky A.   +9 more
europepmc   +1 more source

<i>NTRK</i> Gene Fusions: A Compendium of Fusion Partners and Tumor Types. [PDF]

JCO Precis Oncol
Yang SR, Repetto M, Rudzinski ER, Li MM, Roy A, Gutstein L, Huang K, Wu J, Glade Bender J, Brega N, Buchberg AM, Bernard-Gauthier V, Hong DS, Drilon A, Laetsch TW.   +14 more
europepmc   +1 more source

Successful simplified genomic profiling of cytology specimens using Aspyre Clinical Test for Lung (Tissue)

Cancer Cytopathology, Volume 134, Issue 7, July 2026.
Cytology specimens from patients with non–small cell lung cancer were tested using Aspyre Clinical Test for Lung (Tissue) and the results compared to an orthogonal assay. 84/85 samples passed quality control, and all detected variants matched expected results including SNVs from KRAS, SNVs and indels from EGFR, MET exon 14 skipping and gene fusions in ...
Caren Gentile, Sarah E. Herlihy, Elyse Shapiro, Ryan Thomas Evans, Amanda Shull Green, Candace King, Mary Beth Rossi, Elizabeth Gillon‐Zhang, James Schaffernoth, Katherine Elizabeth Knudsen, Cory Kiser, Tatiana Yuen, Ana‐Luisa Silva, Eleanor Ruth Gray, Barnaby William Balmforth, Wendy Jo Levin, Jeffrey Gregg, Vivianna Van Deerlin   +17 more
wiley   +1 more source