Oncogene proteins, fusion - Open Access .click

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NAB2-STAT6 fusion protein mediates cell proliferation and oncogenic progression via EGR-1 regulation

Biochemical and Biophysical Research Communications, 2020
Solitary fibrous tumors are rare mesenchymal tumors derived from soft tissues and vascular walls. NAB2-STAT6 fusion gene serves as a marker gene for this disease and consists of the truncated repressor domain of NGFI-A-Binding protein 2 (NAB2) and the intact activation domain of STAT6.
Ye-Seul Park +7 more
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Abstract 4968: Modes of co-factor recruitment by an oncogenic fusion protein

Cancer Research, 2010
Abstract Ewing's sarcoma (ESFT) is a highly aggressive pediatric cancer of the bone and characterized by the chimeric ETS transcription factor EWS-FLI1 as a result of a chromosomal translocation. By whole genome gene expression and ChIP-seq analyses we obtained evidence that EWS-FLI1 directly regulates E2F target genes and possibly ...
Raphaela Schwentner +6 more
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PROTEIN-PROTEIN INTERACTION NETWORK PERTURBATIONS CAUSED BY ONCOGENIC FUSION EVENTS

144 pages ; Supplemental file(s) description: None. ; Proteins rarely work in isolation but rather function in combinations and complexes. Considering diseases driven by changes at the network level, rather than at the individual protein level has driven the recent development of the strategy of drugging “networks.” My research focuses on gene fusions,
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Oncogenic mechanisms of fusion proteins in pediatric acute myeloid leukemia