Results 271 to 280 of about 103,602 (308)

Crizotinib-induced hyperlipidemia in advanced lung adenocarcinoma: A case report and literature review. [PDF]

Medicine (Baltimore)
Ren S, Chen R.
europepmc   +1 more source

Genomic profiling of a DICER1-wildtype thyroblastoma reveals AGK-BRAF fusion, EIF1AX duplication, and TERT promoter mutations: integrated genomic and pathway analysis. [PDF]

Front Endocrinol (Lausanne)
Gualandi A, Picozzi F, Di Mauro A, Pelotti S, D'Arbitrio I, De Luca P, Cannella L, Pizzolorusso A, Ottaiano A, Peddio A, Ferrara G, Tafuto S.   +11 more
europepmc   +1 more source

Autophagy in Ovarian Cancer, an Opportunity or an Additional Threat? [PDF]

Int J Mol Sci
Zoń A, Bednarek IA.
europepmc   +1 more source

Genomic Landscape Analysis of Canine Pulmonary Adenocarcinoma Reveals Candidate Targetable Gene Fusions. [PDF]

Vet Comp Oncol
Sakthikumar S, Hendricks WPD, Rainford D, Selleck W, Briones N, Coggins C, Quan N, Zismann V, Lorch G, Sekulic A, Trent JM.   +10 more
europepmc   +1 more source

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Development of a degrader against oncogenic fusion protein FGFR3-TACC3

Bioorganic & Medicinal Chemistry Letters, 2022
Fibroblast growth factor receptor 3-transforming acidic coiled-coil containing protein 3 (FGFR3-TACC3), which has been identified in many cancers such as glioblastoma and bladder cancer, is a potent oncogenic fusion protein that induces constitutive activation of FGFR signaling, resulting in uncontrolled cell proliferation.
Norihito, Shibata, Nobuo, Cho, Hiroo, Koyama, Mikihiko, Naito   +3 more
openaire   +2 more sources

A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences [PDF]

Nature, 1986
A biologically active complementary DNA clone of a transforming gene present in a human colon carcinoma contains gene sequences of both tropomyosin and a previously unknown protein tyrosine kinase. The predicted protein (641 amino acids) encoded by this oncogene seems to have been formed by a somatic rearrangement that replaced the extracellular domain
Dionisio Martin-Zanca, Mariano Barbacid, D Martin-Zanca   +2 more
exaly   +4 more sources

Pediatric Acute Megakaryoblastic Leukemia: Multitasking Fusion Proteins and Oncogenic Cooperations

Trends in Cancer, 2017
Pediatric leukemia presents specific clinical and genetic features from adult leukemia but the underpinning mechanisms of transformation are still unclear. Acute megakaryoblastic leukemia (AMKL) is the malignant accumulation of progenitors of the megakaryocyte lineage that normally produce blood platelets. AMKL is diagnosed de novo, in patients showing
Cécile K, Lopez, Sébastien, Malinge, Muriel, Gaudry, Olivier A, Bernard, Thomas, Mercher   +4 more
openaire   +2 more sources

The immune response to oncogenic fusion proteins

2001
Chromosomal translocations represent somatically acquired cytogenetic mutations. When chromosomal breaks occur within exons of two different genes, the consequence of chromosomal translocation is the creation of a new fusion gene encoding for a chimeric protein.
Lorena Passoni, Carlo Gambacorti-Passerini   +1 more
openaire   +1 more source

FGFR2 fusion proteins drive oncogenic transformation of mouse liver organoids towards cholangiocarcinoma

Journal of Hepatology, 2021
About 15% of intrahepatic cholangiocarcinomas (iCCAs) express fibroblast growth factor receptor 2 (FGFR2) fusion proteins (FFs), usually alongside mutational inactivation of TP53, CDKN2A or BAP1. In FFs, FGFR2 residues 1-768 fuse to sequences encoded by a diverse array of partner genes (>60) causing oncogenic FF activation. While FGFR-specific tyrosine
Giulia Cristinziano, Manuela Porru, Dante Lamberti, Simonetta Buglioni, Francesca Rollo, Carla Azzurra Amoreo, Isabella Manni, Diana Giannarelli, Cristina Cristofoletti, Giandomenico Russo, Mitesh J. Borad, Gian Luca Grazi, Maria Grazia Diodoro, Silvia Giordano, Andrea Sacconi, Mattia Forcato, Sergio Anastasi, Carlo Leonetti, Oreste Segatto   +18 more
openaire   +4 more sources