Results 51 to 60 of about 369,580 (326)
Haematologica, 2013 Acute lymphoblastic leukemia in infants represents an aggressive malignancy associated with a high incidence (approx. 80%) of translocations involving the Mixed Lineage Leukemia (MLL) gene.
Emma M.C. Driessen +7 more
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Changes in TFG gene expression in bovine leucocytes transformed by Theileria annulata
Frontiers in Veterinary Science, 2022 Theileria annulata schizont-infected host cells in culture in vitro show unlimited proliferation similar to tumor cells; thus far, T. annulata and T. parva are the only eukaryotes that have been found to transform mammalian cells (immortalized).
Hong-xi Zhao +4 more
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Intrinsic Structural Disorder Confers Cellular Viability on Oncogenic Fusion Proteins
PLoS Computational Biology, 2009 Chromosomal translocations, which often generate chimeric proteins by fusing segments of two distinct genes, represent the single major genetic aberration leading to cancer. We suggest that the unifying theme of these events is a high level of intrinsic structural disorder, enabling fusion proteins to evade cellular surveillance mechanisms that ...
Hedi Hegyi, László Buday, Peter Tompa
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Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma. [PDF]
, 2014 Ewing sarcoma is the second-most-common bone cancer in children. Driven by an oncogenic chromosomal translocation that results in the expression of an aberrant transcription factor, EWS/FLI, the disease is typically aggressive and micrometastatic upon ...
Beckerle, Mary C +8 more
core +1 more source
Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors
Nature Communications, 2018 Altered mitochondrial dynamics can broadly impact tumor cell physiology. Using genetic and pharmacological profiling of cancer cell lines and human tumors, we here establish that perturbations to the mitochondrial dynamics network also result in specific
Gray R. Anderson +9 more
semanticscholar +1 more source
Homotypic and heterotypic interactions of EWS, FLI1 and their oncogenic fusion protein [PDF]
Oncogene, 2003 In Ewing's sarcoma family tumors, the ets transcription factor gene FLI1 is rearranged with one EWS allele resulting in coexpression of germline EWS and chimeric EWS-FLI1 proteins. Here, we investigated the potential of germline EWS, FLI1 and EWS-FLI1 to oligomerize. In two functional in vivo tests, fluorescence resonance energy transfer (FRET) and the
Laura, Spahn +5 more
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FUS-CHOP promotes invasion in myxoid liposarcoma through a SRC/FAK/RHO/ROCK-dependent pathway [PDF]
, 2017 Deregulated SRC/FAK signaling leads to enhanced migration and invasion in many types of tumors. In myxoid and round cell liposarcoma (MRCLS), an adipocytic tumor characterized by the expression of the fusion oncogene FUS-CHOP, SRC have been found as one ...
González, M. Victoria +3 more
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Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia [PDF]
Nature Chemical Biology, 2012 Translocations involving the mixed lineage leukemia (MLL) gene result in human acute leukemias with very poor prognosis. The leukemogenic activity of MLL fusion proteins is critically dependent on their direct interaction with menin, a product of the multiple endocrine neoplasia (MEN1) gene.
Jolanta, Grembecka +11 more
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Communications Biology, 2023 Abstract TAZ::CAMTA1 is a fusion protein found in over 90% of Epithelioid Hemangioendothelioma (EHE), a rare vascular sarcoma with an unpredictable disease course. To date, how TAZ::CAMTA1 initiates tumour formation remains unexplained.
Emily Neil +4 more
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FGFR–TACC Fusion Proteins Are Oncogenic in Glioblastoma [PDF]
Cancer Discovery, 2012 Abstract Fusion proteins combining FGFR and TACC are transforming in a subset of glioblastomas.
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