Results 261 to 270 of about 628,495 (277)

G-Protein Oncogenes in Acromegaly

Hormone Research, 1992
G-proteins belong to a family of proteins which share the common properties of GTP binding and hydrolysis. Heterotrimeric G-proteins are composed of alpha-, beta- and gamma-subunits. The alpha-subunit which differs from one G-protein to another contains the GDP/GTP binding site and has intrinsic GTPase activity.
A, Spada, L, Vallar
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Serum Oncogene Proteins in Foundry Workers

Occupational Medicine, 1990
A new technique for detecting oncogene activation based on immunoblotting for oncogene proteins in serum has been applied to screen a cohort of foundry workers with well-defined workplace exposures to polycyclic aromatic hydrocarbon carcinogens. Three of the 18 individuals screened were found to have abnormal expression of the proteins of the ras and ...
P W, Brandt-Rauf, S, Smith, F P, Perera, H L, Niman, W, Yohannan, K, Hemminki, R M, Santella   +6 more
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The ras Oncogene Protein

1989
To date, over 40 discrete genes (oncogenes and proto-oncogenes) have been shown capable of inducing cellular transformation and tumor development (Bishop 1987). Only a few of these oncogenes have actually been shown to have a significant role in human cancer.
M. S. Marshall, M. D. Schaber, U. S. Vogel, W. S. Hill, A. S. Ng, E. M. Scolnick, R. A. F. Dixon, I. S. Sigal, J. B. Gibbs   +8 more
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Oncogenes encoding protein kinases

Trends in Genetics, 1985
Abstract At least half of the more than 20 known proto-oncogenes encode proteins which phosphorylate polypeptide substrates. This suggests that protein phosphorylation plays a central role inthe regulation of cellular multiplication, glucose metabolism and cell shape and that a surprisingly large number of protein kinases exert control over these ...
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Targeting Oncogenic RAS Protein

New England Journal of Medicine, 2022
Dan L, Longo, Neal, Rosen
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G Protein Oncogenes

1991
This review will describe experiments aimed at answering two questions raised by the recent convergence of research on signal-transducing G proteins and oncogenes: What roles do individual G proteins play in normal regulation of cell proliferation? How do dominantly acting G protein oncogenes contribute to tumorigenesis, in experimental systems and in ...
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Oncogenic mechanisms of Evi-1 protein

Cancer Chemotherapy and Pharmacology, 2001
Although Evi-1 is thought to promote growth or block differentiation in some cell types, its biological functions have not been elucidated. To explore the mechanisms underlying Evi-1-induced oncogenesis, we investigated whether Evi-1 affects the signaling of transforming growth factor beta (TGF-beta), which inhibits proliferation of a wide range of ...
H, Hirai, K, Izutsu, M, Kurokawa, K, Mitani   +3 more
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G protein oncogenes in pituitary tumors

Trends in Endocrinology & Metabolism, 1992
G proteins are involved in the transduction of external signals from cell surface receptors to intracellular effectors. Somatic mutations activating the a-subunit of G(s) (the stimulatory regulatory protein of adenylyl cyclase) by inhibiting its intrinsic GTPase activity have been first identified in human GH-secreting adenomas and subsequently found ...
A, Spada, L, Vallar, G, Faglia
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Potential oncogenic hazards posed by oncogene encoded proteins.

Developments in biological standardization, 1988
The theoretical risk from oncogene encoded proteins is limited to growth factors, which may be secreted by cells in which biologically derived products might be manufactured. Because these peptides do not replicate, their effect is finite. In addition, their effects are reversible. Growth factors do not ordinarily appear to be oncogenic.
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Immunity to Oncogenic Proteins

Immunological Reviews, 1995
M A, Cheever, M L, Disis, H, Bernhard, J R, Gralow, S L, Hand, E S, Huseby, H L, Qin, M, Takahashi, W, Chen   +8 more
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