Results 211 to 220 of about 384,141 (378)

Superenhancers shape the landscape and repair dynamics of transcription-associated DNA breaks in cancer. [PDF]

Sci Adv
Hidmi O, Shatleh D, Flayshman SO, Monin J, Aqeilan RI.   +4 more
europepmc   +1 more source

Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status

Nature, 2002
H. Rajagopalan, A. Bardelli, C. Lengauer, K. Kinzler, B. Vogelstein, V. Velculescu   +5 more
semanticscholar   +1 more source

Comprehensive Profiling of N6‐methyladnosine (m6A) Readouts Reveals Novel m6A Readers That Regulate Human Embryonic Stem Cell Differentiation

Advanced Science, EarlyView.
This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang, Rucong Liu, Zibaguli Wubulikasimu, Wanqing Zhao, Jiaqi Huang, Jiaxuan Wang, Tianyuan Zhang, Rui Fan, Wei Kong, Qinghua Cui, Yang Li, Yuan Zhou   +11 more
wiley   +1 more source

Transposons disrupt genomic stability and trigger cancers. [PDF]

Front Cell Infect Microbiol
Dong W, Li M, Li P, Hou X, He F, Ji S.
europepmc   +1 more source

SOX10 is a novel oncogene in hepatocellular carcinoma through Wnt/β-catenin/TCF4 cascade

, 2014
Zhou Dangjun, Fengjiao Bai, Xinning Zhang, Minggen Hu, Guodong Zhao, Zhiming Zhao, Rong Liu   +6 more
openalex   +1 more source

microRNAs as oncogenes and tumor suppressors.

Developmental Biology, 2007
Baohong Zhang, Xiaoping Pan, G. Cobb, T. Anderson   +3 more
semanticscholar   +1 more source

p16Ink4a‐Positive Hepatocytes Drive Liver Fibrosis Through Activation of LIFR Family Pathway

Advanced Science, EarlyView.
This study found that, following the long‐term CCl4 treatment, p16high hepatocytes appeared in zone 3, spatially co‐localizing with fibrotic areas. A specific cluster of p16high hepatocytes upregulated CTF1/LIF expression which induced HSC activation and further liver fibrosis, as revealed by single cell transcriptomic analysis.
Koji Nishikawa, Teh‐Wei Wang, Satoshi Kawakami, Shota Tanimoto, Kiyoshi Yamaguchi, Taketomo Kido, Masamichi Kimura, Tsunekazu Hishima, Yuki T. Okamura, Satotaka Omori, Takumi Iritani, Toshikaze Chiba, Takehiro Jimbo, Michio Katano, Kansuporn Kamataki, Ryoichi Yokoyama, Eigo Shimizu, Kiminori Kimura, Satoshi Yamzaki, Seiya Imoto, Yoichi Furukawa, Atsushi Miyajima, Yoshikazu Johmura, Makoto Nakanishi   +23 more
wiley   +1 more source

CRISPR/CAS9-based gene editing in cancer therapy: A systematic review and meta-analysis on current status and future directions. [PDF]

Medicine (Baltimore)
Rehman SU, Abbas GH.
europepmc   +1 more source

ACSL5 Regulates Glucose Metabolism and Chemotherapy Sensitivity in Colorectal Cancer Cells under Glutamine Deficiency

Advanced Science, EarlyView.
Glutamine deprivation triggers ACSL5 upregulation in tumor cells, sustaining their viability via dual metabolic rewiring programs. ACSL5 enhances glycolysis by relieving p53's inhibition of PGAM1 while also sustaining mitochondrial respiration and TCA cycle flux through promoting IDH2 dimerization.
Shuai Tian, Qiaoxia Zhang, Xuedan Sun, Rick Francis Thorne, Zeyuan Shi, Qiang Ji, Zhangran Sun, Yuanxiang Lu, Qun Zhao, Xianjun Yu, Wanglai Hu, Mian Wu   +11 more
wiley   +1 more source

Design of Anti-Tumor RNA Nanoparticles and Their Inhibitory Effect on Hep3B Liver Cancer. [PDF]

Biomolecules
Sun S, Yan L, Liu Z, Jin W.
europepmc   +1 more source