Results 191 to 200 of about 177,226 (290)

Monitoring pharmacodynamic and molecular drug targets in liquid biopsy: Exploratory study in liver cancer with modelling of EGFR Receptor engagement

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Liquid biopsy is minimally invasive (compared with tissue biopsy) and has previously been used to generate systems data regarding drug elimination via hepatic enzymes and transporters. This study extends quantitative assessment of systems parameters in liquid biopsy to pharmacodynamic (PD) and disease markers relevant to cancer development
Zubida M. Al‐Majdoub, Armin Sepp, Amin Rostami‐Hodjegan, Brahim Achour   +3 more
wiley   +1 more source

A dependency map enhanced with next-generation 3D cancer models. [PDF]

Nature
Neiswender JV, Maffa S, Brenan L, ElHarouni D, Yun Y, Boyle I, Wienand K, Inam H, Bertea T, Anderson A, Wong M, Enriquez M, Lenz E, Villafranca B, Shanks N, Hager M, Lloyd N, Shadmany H, Wie SJ, Liang H, Yunghans K, Zhang X, Golden L, Harris H, Day S, Montgomery P, Stokes S, Giglio RM, Hajal C, Whittle JR, Garcia G, Mills CE, Touat M, Pelton K, Li H, Prabhakar PS, Herter S, Kamrat ZH, Gui D, Dilly J, Wong CK, Guo JA, Pal S, Baidi Y, Johnston R, Brown DD, Bhatia S, Winter PS, Raghavan S, Beroukhim R, Colas E, Spector DL, Bass AJ, Sorger PK, Chen Y, Hill SJ, Oesterreich S, Lee AV, Beltran H, Boehm JS, Tseng YY, Root DE, Hahn WC, Aguirre AJ, Campbell CD, Ligon KL, Dempster JM, Shibue T, Vazquez F.   +68 more
europepmc   +1 more source

What Makes an “Ideal” Cell Line for Recombinant Adeno‐Associated Virus Production?

Biotechnology and Bioengineering, EarlyView.
Several host cell types have been used to produce rAAVs to date. Cell line‐specific traits that are beneficial in the context of rAAV manufacturing are reviewed here, with the goal of developing a consensus on the ‘ideal’ characteristics that an rAAV production host should possess (created with Biorender.com).
James Conheady, Nicholas Donohue, Alexandra Bogdanovic, Sharon Davin, Brian Glennon, Niall Barron, C. Mark Smales   +6 more
wiley   +1 more source

The Extrachromosomal DNA Fusion Factory: Extrachromosomal Genesis of Oncogenic Fusion Transcripts. [PDF]

Research (Wash D C)
Maimaitiyiming Y, Yang C, Hua Naranmandura.   +2 more
europepmc   +1 more source

Purification of Advanced Therapeutics by Flow‐Through Pseudo‐Affinity Chromatography: Bi‐Specific mABs, Fc Fusion Proteins, and Adeno‐Associated Viruses

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu, Eduardo Barbieri, Arianna Minzoni, Shriarjun Shastry, Jacob P. LeBarre, Qingbo Shu, Taufika Williams, Xuanwen Li, Divya Chandra, Xuankuo Xu, Jerome Bill, David Roush, Joseph Taris, Patrick Gilbert, Andre Kiesewetter, Oliver Rammo, Michael Schulte, Christopher Major, Trina Mouchahoir, Steven Cramer, Cristiana Boi, Ruben G. Carbonell, Abraham Lenhoff, Stefano Menegatti   +23 more
wiley   +1 more source

Establishment of an immortalized porcine erythroid progenitor cell line using species-adapted papillomavirus oncogenes. [PDF]

Front Bioeng Biotechnol
Tran TM, Lee HH, Hwang TH, Kim MH, Dang NM, Lee MG, Shim J, Hwang JH, Kim JY.   +8 more
europepmc   +1 more source

2D copper nanozyme patches facilitate bone regeneration via interfacial modulation of osteoclast‐osteoblast dynamics

BMEMat, EarlyView.
This study develops a nano‐enzyme patch (ezPatch) targeting bone interfaces. Utilizing ligand‐to‐metal charge transfer (LMCT) catalysis and bone‐targeting ligands on copper nanosheets, ezPatch simultaneously scavenges reactive oxygen species (ROS) and generates oxygen in situ at bone‐losing sites.
Yi Chen, Haoyue Hu, Danyang Wang, Ying Wang, Zhibang Li, Xiaoyi Liu, Yandi Zhang, Junkun Feng, Weiwei Zhao, Kai Li, Qi‐Zhi Zhong, Shaohua Ge, Jianhua Li   +12 more
wiley   +1 more source

Corrigendum to "Global trends, age-period-cohort analysis, and future projections of diarrhea burden: Findings from the Global Burden of Disease Study 2021" [Biosafety and Health 7 (2025) 295-305]. [PDF]

Biosaf Health
Xie M, Song Y, Tao J, Jiang M, Liu Y, Cheong IH, Kozlakidis Z, Chang Z, Wei Q.   +8 more
europepmc   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Editorial: Editors’ showcase: insights in cancer cell biology

Frontiers in Cell and Developmental Biology
Geoffrey Brown, Andrew Liss, Andrew Liss
doaj   +1 more source