Results 211 to 220 of about 177,226 (290)

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, EarlyView.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source

CRISPR Interference to Inhibit Oncogenes for Cancer Therapy. [PDF]

Int J Mol Sci
Guo B.
europepmc   +1 more source

Bone marrow‐like viscosity affects imatinib resistance in chronic myeloid leukemia

Biotechnology Progress, EarlyView.
Physical cues such as microenvironmental viscosity have been recognized as important regulators in controlling cell functions. However, even though the bone marrow (BM) is a viscous tissue in which cells respond mechanically to both the matrix stiffness and the viscosity of surrounding fluid, the impact of microenvironmental viscosity on imatinib (IM ...
Tianjiao Zeng, Huajian Chen, Man Wang, Toru Yoshitomi, Naoki Kawazoe, Yingnan Yang, Guoping Chen   +6 more
wiley   +1 more source

Retraction Note: The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma. [PDF]

Nat Commun
Li Z, Zhang J, Liu X, Li S, Wang Q, Chen D, Hu Z, Yu T, Ding J, Li J, Yao M, Fan J, Huang S, Gao Q, Zhao Y, He X.   +15 more
europepmc   +1 more source

Characterization of the Interaction of Known G‐quadruplex Ligands With a Minimal i‐Motif Structure

Chemistry – A European Journal, EarlyView.
The destabilization of a minimal i‐Motif (iM) structure by TMPyP4 is driven by ligand recognition of one terminal iM structural domain. ABSTRACT Peculiar genomic regions are prone to evolve transiently from double‐helix DNA to noncanonical secondary structures in response to physiological stress.
Davide Auricchio, Marko Trajkovski, Janez Plavec, Claudia Sissi   +3 more
wiley   +1 more source

Editorial: Novelties in acute myeloid leukemia: from biology to clinical applications

Frontiers in Oncology
Luca Vincenzo Cappelli, Nico Gagelmann, Hassan Awada, Carmelo Gurnari, Carmelo Gurnari   +4 more
doaj   +1 more source

Multi-modal data integration reveals functionally credible predictive biomarkers in ovarian cancer. [PDF]

Genome Med
Muranen TA, Hainari A, Afenteva D, Senkowski W, Oikkonen J, Dreo J, Driva K, Holmström S, Isoviita VM, Lahtinen A, Lavikka K, Li Y, Lovino M, Maarala I, Marchi G, Miccolis F, Micoli G, Najm M, Ostwaldt AC, Rodriguez-Mier P, Söderlund J, Hietanen S, Virtanen A, Saez-Rodriguez J, Ficarra E, Schwikowski B, Alanne E, Wennerberg K, Hautaniemi S, Hynninen J.   +29 more
europepmc   +1 more source

A Cytosine‑Bulged (3+1) Hybrid G‑Quadruplex Formed by the Chicken DNA Replication Origin

Chemistry – A European Journal, EarlyView.
The first high‐resolution structure of an OGRE‐derived G‐quadruplex from the chicken β‐globin replication origin reveals an intramolecular three‐layer (3+1) hybrid fold with a cytosine bulge and an unprecedented 5'‐outer‐quartet anti guanine, creating a distinctive surface for molecular recognition.
Yingying You, Monica Ching Suen, Haitao Miao, Yanyan Geng, Rahman Ud Din, Mu Yuan, Qiang Xue, Xiaoting Li, Naining Xu, Zhihong Guo, Hon‐Ming Lam, Kwok‐Wai Lo, Changdong Liu, Guang Zhu   +13 more
wiley   +1 more source

Global changes in gene expression and splicing in alcoholic liver disease. [PDF]

Sci Rep
Blokhin IO, Van Booven D, Argemi J, Li M, Rao JS, Barbier E, Heilig M, Cheng J, Douaihy AB, Bataller R, Wahlestedt C.   +10 more
europepmc   +1 more source

Introduction of a Double‐Headed Nucleotide Into G‐Quadruplex DNA: Position‐Dependent Stabilization and Structural Insights

Chemistry – A European Journal, EarlyView.
A double‐headed bis‐guanine (G) nucleotide (GG) was evaluated as a noncanonical building block in G‐quadruplexes (G4s). Biophysical and computational analyses reveal that GG can directly participate in G‐tetrads and strongly stabilize G4s in a position‐ and topology‐dependent manner. These findings establish design rules for using GG to engineer highly
Krista Urup, Peter Reinholdt, Kasper Munch Beck, Michael Petersen, Jean‐Louis Mergny, Poul Nielsen   +5 more
wiley   +1 more source