Results 171 to 180 of about 177,226 (290)

Plant Virus Immunotherapy for HPV‐Associated Oropharyngeal Squamous Cell Carcinoma

Advanced NanoBiomed Research, EarlyView.
Cowpea mosaic virus (CPMV) nanoparticles are safe and potent cancer immunotherapy candidates with strong immunomodulatory activity. CPMV activates innate immunity, which in turn drives adaptive immune responses and promotes durable, systemic antitumor effects.
Jessica Fernanda Affonso de Oliveira, Patrick Opdensteinen, Andrea Simms, Seongwon Jung, Giuliana P. Mognol, Hui Chen, Judith A. Varner, Nicole F. Steinmetz   +7 more
wiley   +1 more source

3D chromatin architecture in cancer: mechanisms of dysregulation and emerging therapeutic strategies. [PDF]

Exp Mol Med
Jang S, Yoo KH.
europepmc   +1 more source

MET-amplified gastric cancers exhibit co-amplifications of BRAF, CDK6, and EGFR. [PDF]

J Pathol Clin Res
Lüschen S, Ebert U, Behrens HM, Krüger S, Ulase D, Amallraja A, Heckl SM, Becker T, Rosenstiel P, Meißner T, Röcken C.   +10 more
europepmc   +1 more source

Examining the role of extrachromosomal DNA in lung cancer. [PDF]

J Natl Cancer Inst
Khandekar A, Hoang PH, Luebeck J, Díaz-Gay M, Zhao W, McElderry JP, Hartman C, Miraftab M, Lee OW, Barnao KM, Jones K, Hutchinson A, Hicks B, Bergstrom EN, Yang Y, Nowak MA, Rothman N, Pesatori AC, Consonni D, Homer R, Baine MK, Sholl LM, Joubert P, Leduc C, Travis WD, Yang SR, Lan Q, Wedge DC, Yang L, Chanock SJ, Zhang T, Alexandrov LB, Landi MT.   +32 more
europepmc   +1 more source

Empowering Inference of Epistasis on the Basis of Mutual Exclusivity, Co-Occurrence, Functional Antagonism and Synergy in ERK-Pathway Oncogenes. [PDF]

Int J Cancer
Townsend JP.
europepmc   +1 more source

Discovery of an Antiviral Electron Transfer Process to Create Catalytically Self‐Sufficient Viral Restriction Factors

Angewandte Chemie International Edition, EarlyView.
CYB5R3 is identified as a putative electron‐transfer partner of viperin (RSAD2), explaining why ER localisation is required for antiviral activity. Its utilisation enabled the engineering of immune‐silent, catalytically self‐sufficient antiviral restriction factor enzymes (iCAREs) that produce an antiviral nucleoside triphosphate analogue (ANTA ...
Mengdi Wu, Nghi Thao Hoang, Deborah Grifagni, Meritxell Wu‐Lu, Yujie Sheng, Theo Situmorang, Pei‐Hsin Tai, Zheng Chen, Astrid Maluta, Mohammed Hakil, Bianca Susini, Hannah Florance, Peter‐Leon Hagedoorn, John Mark Sutton, Maria‐Andrea Mroginski, Simone Ciofi‐Baffoni, Kourosh H. Ebrahimi   +16 more
wiley   +1 more source

Oncogene amplification of CCND1 via extrachromosomal DNA impacts overall survival in head and neck squamous cell carcinoma. [PDF]

Discov Oncol
Tsou P, Wu CJ.
europepmc   +1 more source

Genome-wide mapping reveals increased R-loops in topoisomerase III-beta-deficient human cells. [PDF]

iScience
Saha S, Dhall A, Huang SN, Saha LK, Al Mahmud MR, Zhang H, Sun Y, Pommier Y.   +7 more
europepmc   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

Copy Number-Based Oncogene Dominance May Suggest ERBB2 Dependence and Trastuzumab Response in HER2-Positive Gastric Cancer. [PDF]

Target Oncol
Wakatsuki T, Yamamoto N, Ishizuka N, Hironaka S, Minashi K, Kadowaki S, Hirano H, Shoji H, Yamaguchi T, Chin K, Ogura M, Nakayama I, Osumi H, Ueki A, Kitano S, Boku N, Yamaguchi K, Takahari D.   +17 more
europepmc   +1 more source