Results 241 to 250 of about 384,141 (378)

Disrupting the Formation of YAP Condensates Promotes the Activation of AMPKα to Inhibit the Progression of Primary Liver Cancer

Advanced Science, EarlyView.
This study systematically investigates the function and molecular mechanisms of YAP phase separation in multiple primary liver cancers. These findings provide novel insights into phase separation‐mediated primary liver cancer development and validate targeted disruption of this process as an effective therapeutic strategy for primary liver cancer ...
Shuang‐Zhou Peng, Jia‐Jia Liang, Yun‐Feng Zhan, Wei‐Xun Wu, Wan‐Li Xu, Xiao‐Kun Zhang, Li‐Jun Cai, Fu‐Quan Jiang   +7 more
wiley   +1 more source

A novel mechanism by which c-MYC is aberrantly activated by epigenetic silencing of its antisense lncRNA in colon cancer. [PDF]

Front Genet
Hu X, Wei Y, Zhang M, Dou C, Wang L, Zaib G, Wu H, Guo W, Wang X, Chen S, Xu Q, Guo M, Cui H.   +12 more
europepmc   +1 more source

Data from Cyclin D1 Restrains Oncogene-Induced Autophagy by Regulating the AMPK–LKB1 Signaling Axis

, 2023
Mathew C. Casimiro, Gabriele Di Sante, Agnese Di Rocco, Emanuele Loro, Claudia Pupo, Timothy G. Pestell, Sara Bisetto, Marco A. Velasco‐Velázquez, Xuanmao Jiao, Zhiping Li, Christine M. Kusminski, Erin L. Seifert, Chenguang Wang, Daniel Ly, Bin Zheng, Che‐Hung Shen, Philipp E. Scherer, Richard G. Pestell   +17 more
openalex   +1 more source

Learned Conformational Space and Pharmacophore Into Molecular Foundational Model

Advanced Science, EarlyView.
The Ouroboros model introduces two orthogonal modules within a unified framework that independently learn molecular representations and generate chemical structures. This design enables flexible optimization strategies for each module and faithful structure reconstruction without prompts or noise.
Lin Wang, Yifan Wu, Hao Luo, Minglong Liang, Yihang Zhou, Cheng Chen, Chris Liu, Jun Zhang, Yang Zhang   +8 more
wiley   +1 more source

ELViS: an R package for estimating copy number levels of viral genomic segments at base-resolution. [PDF]

Bioinformatics
Lee JY, Holt JR, Zhao X, Hoadley KA, Hayes DN, Choi HY.   +5 more
europepmc   +1 more source

HoxA9 transforms murine myeloid cells by a feedback loop driving expression of key oncogenes and cell cycle control genes [PDF]

, 2018
Xiaoxia Zhong, Andreas Prinz, Julia Steger, María-Paz García-Cuéllar, Markus P. Radsak, Abderrazzak Bentaher, Robert K. Slany   +6 more
openalex   +1 more source

Supplementary Methods and Materials from Targeting the EWSR1-FLI1 Oncogene-Induced Protein Kinase PKC-β Abolishes Ewing Sarcoma Growth

, 2023
Didier Surdez, Magdalena Benetkiewicz, Virginie Perrin, Zhi-Yan Han, Gaëlle Pierron, Stelly Ballet, François Lamoureux, Françoise Rédiní, Anne‐Valérie Decouvelaere, Estelle Daudigeos‐Dubus, Birgit Geoerger, Gonzague de Pinieux, Olivier Delattre, Franck Tirode   +13 more
openalex   +1 more source

Oncogenic osteomalacia [PDF]

QJM: An International Journal of Medicine, 2019
S-Z, Liu, X, Zhou, A, Song, Y-P, Wang, Y, Liu   +4 more
openaire   +2 more sources

Bcl-2 initiates a new category of oncogenes: regulators of cell death.

Blood, 1992
S. Korsmeyer
semanticscholar   +1 more source

Combined Photothermal and mTOR‐Targeted Therapy Overcomes Immune Evasion and Enhances Checkpoint Blockade Efficacy in Metastatic Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study reveals that photothermal therapy, while inducing immunogenic cell death in triple‐negative breast cancer, paradoxically activates the oncogenic mTOR pathway to drive immune evasion. To counter this, a smart nanocomposite is engineered to co‐deliver localized hyperthermia and mTOR inhibition.
Yujie Zhao, Jing Yu, Xin Wang, Xu Liu, Fengli Zuo, Tianyue Xu, Leyi Tang, Ling Xiong, Li Li, Huifang Li, Xiaoting Chen, Guang Yang, Jing Jing, Xiaowei Liu   +13 more
wiley   +1 more source