Results 281 to 290 of about 384,141 (378)

Systematic bioinformatics analysis identifies shikonin as a novel mTOR pathway inhibitor in triple-negative breast cancer progression. [PDF]

Front Pharmacol
Liu W, Liu Q, Yao J, Wu D, Li W, Fu Z, Zhao M, Liang Y.   +7 more
europepmc   +1 more source

GTPase-deficient G alpha i2 oncogene gip2 inhibits adenylylcyclase and attenuates receptor-stimulated phospholipase A2 activity

, 1991
Joseph M. Lowndes, Sunil Gupta, Shoji Osawa, Gary L. Johnson   +3 more
openalex   +1 more source

MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes.

Cancer Research, 2009
Yunqing Li, F. Guessous, Ying Zhang, C. Dipierro, B. Kefas, E. Johnson, Lukasz Marcinkiewicz, Jinmai Jiang, Yanzhi Yang, Thomas D. Schmittgen, Beatriz Lopes, D. Schiff, B. Purow, R. Abounader   +13 more
semanticscholar   +1 more source

Inferring Gene Regulatory Networks From Single‐Cell RNA Sequencing Data by Dual‐Role Graph Contrastive Learning

Advanced Science, EarlyView.
RegGAIN is a novel and powerful deep learning framework for inferring gene regulatory networks (GRNs) from single‐cell RNA sequencing data. By integrating self‐supervised contrastive learning with dual‐role gene representations, it consistently outperforms existing methods in both accuracy and robustness.
Qiyuan Guan, Jiating Yu, Jieyi Pan, Fan Yuan, Jiadong Ji, Rusong Zhao, Zhi‐Ping Liu, Bingqiang Liu, Ling‐Yun Wu, Duanchen Sun   +9 more
wiley   +1 more source

3D-bioprinted liver cancer models derived from primary hepatocytes for simulating cancer initiation and drug screening. [PDF]

Hepatol Commun
Zhao Y, Li Y, Zhang W, Jiang H, Mao L, He R, Ma Y, Wang Q, Huang P.   +8 more
europepmc   +1 more source

Repression of transforming growth factor beta 1 promoter by the adenovirus oncogene E1A. Identification of a unique GC-rich sequence as a target for E1A repression.

, 1994
Pran K. Datta, Srilata Bagchi
openalex   +1 more source

NUDT21‐mediated Alternative Polyadenylation of CDK19 Reprograms Cholesterol Biosynthesis to Drive Colorectal Cancer Progression

Advanced Science, EarlyView.
NUDT21 is overexpressed in colorectal cancer tumors and promotes colorectal cancer progression. NUDT21 promotes the production of a cyclin‐dependent kinase 19 (CDK19) mRNA isoform with a long 3′ UTR, which enhances cytoplasmic export and translation. Truncation of the CDK19 long 3′ UTR phenocopies NUDT21 loss, recapitulating the defects in cholesterol ...
Yeping Yu, Jixin Ma, Minwei Zhou, Xiaodong Gu, Yiming Zhou, Zhenyang Li, Tianyu Zhang, Wei Gong, Chuanxin Huang, Jianbin Xiang   +9 more
wiley   +1 more source

DNA methylation and prediction of biological age. [PDF]

Front Mol Biosci
Chen Y, Cheng X, Ji S.
europepmc   +1 more source

Do Mutations Turn p53 into an Oncogene?

, 2019
Ivano Amelio, Gerry Melino
openalex   +1 more source

SIRT5–RAC2 Axis Drives Monocyte‐to‐Macrophage Differentiation to Promote Inflammatory Injury in Premature Ovarian Insufficiency

Advanced Science, EarlyView.
SIRT5 desuccinylates and stabilizes RAC2, activating CSF1R‐dependent signaling to drive monocyte differentiation into M0 macrophages and their polarization toward pro‐inflammatory M1 phenotypes in CTX‐induced premature ovarian insufficiency. Inhibiting the SIRT5‐RAC2 axis attenuates inflammation, reduces granulosa cell apoptosis, and preserves ...
Wenjing TanTai, Yaqi Li, Shengnan Liu, Minjuan Wu, Zhixiao Liu, Junfeng Jiang, Jingjing Chen, Xiaoding Xu, Li Li, Chaoqun Li, Fang Zhao, Ye Liu, Haitao Ni, Tengfei Zhang, Mingjuan Xu, Chaofeng Han   +15 more
wiley   +1 more source