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An oncogene is a mutated form of a normal cellular gene – called a proto-oncogene – that contributes to the development of a cancer. Proto-oncogenes typically regulate cell growth and cell differentiation.
حسینی اصل, سید سعید
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Advances on Driver Oncogenes of Lung Adenocarcinoma
, 2013 The adenocarcinoma of the lung has recently shown peculiar molecular characteristics, which relate with both carcinogenesis and response to targeted drugs.
Jinghui WANG, Zongde ZHANG, Shucai ZHANG
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Recent Advances in Liver Cancer Stem Cells: Non-coding RNAs, Oncogenes and Oncoproteins
Frontiers in Cell and Developmental Biology, 2020 Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies worldwide, with high morbidity, relapse, metastasis and mortality rates. Although liver surgical resection, transplantation, chemotherapy, radiotherapy and some molecular targeted ...
Juan Li, Ying Zhu, Ying Zhu
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Characterization of two new human oncogenes
, 1986 The first oncogenes discovered were the transforming genes of the oncogenic viruses (reviewed by Bishop 1985). The subsequent discovery that the oncogenes of retroviruses were derived from normal host cellular genes provided the first direct evidence ...
Wigler, M. H. +2 more
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Expression of the oncogenes mil and ras abolishes the in vivo differentiation of mammary epithelial cells [PDF]
, 1988 Three carcinoma-associated oncogenes, two of which have been strongly implicated in human mammary tumorigenesis, have been introduced into a novel mouse mammary epithelial cell line, EF43, that retains many differentiated functions.
Günzburg, W.H. +13 more
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Deciphering the Dichotomous Effects of PGC-1α on Tumorigenesis and Metastasis
Frontiers in Oncology, 2018 Metabolic reprogramming confers cancer cells the ability to grow and survive under nutrient-depleted or stressful microenvironments. The amplification of oncogenes, the loss of tumor suppressors, as well as context- and lineage-specific determinants can ...
Simon-Pierre Gravel
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