MethodsX, 2018 Zebrafish (Danio rerio) has emerged as a powerful animal model to study developmental processes and human diseases. The introduction of CRISPR/Cas9 as a genome editing tool allowed the generation of genetic mutants with high-throughput (Varshney et al ...
Erica Bresciani +2 more
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Oropharyngeal Shedding of Gammaherpesvirus DNA by Cats, and Natural Infection of Salivary Epithelium
Viruses, 2022 Felis catus gammaherpesvirus-1 (FcaGHV1), a novel candidate oncogenic virus, infects cats worldwide. Whether the oropharynx is a site of virus shedding and persistence, and whether oronasal carcinomas harbor FcaGHV1 nucleic acid were investigated.
Elizabeth C. Rose +9 more
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Brain tumors induced in rats by human adenovirus type 12 [PDF]
, 1974 Oncogenesis of human adenovirus type 12 in the brain of rats was examined. Newborn rats of Sprague-Dawley and Donryu strains were injected intracranially with human adenovirus type 12. The incidence of intracranial tumors was 91% (30/33) in
Matsuo, Keisuke +5 more
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Dual IRE1 RNase functions dictate glioblastoma development
EMBO Molecular Medicine, 2018 Proteostasis imbalance is emerging as a major hallmark of cancer, driving tumor aggressiveness. Evidence suggests that the endoplasmic reticulum (ER), a major site for protein folding and quality control, plays a critical role in cancer development. This
Stéphanie Lhomond +27 more
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ABCC9 Is Downregulated and Prone to Microsatellite Instability on ABCC9tetra in Canine Breast Cancer
Frontiers in Veterinary Science, 2022 Tumorigenesis is associated with metabolic abnormalities and genomic instability. Microsatellite mutations, including microsatellite instability (MSI) and loss of heterozygosity (LOH), are associated with the functional impairment of some tumor-related ...
Pan Hao +5 more
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Expression of PIK3CA mutant E545K in the mammary gland induces heterogeneous tumors but is less potent than mutant H1047R. [PDF]
, 2013 The phosphoinositide 3-kinase (PI3K) signaling cascade is a key mediator of cellular growth, survival and metabolism and is frequently subverted in human cancer.
Bentires-Alj, M +8 more
core +2 more sources
Reliable blood cancer cells' telomere length evaluation by qPCR
Cancer Medicine, 2020 Background Telomere shortening is linked to a range of different human diseases, hence reliable measurement methods are needed to uncover such associations.
Joana Ropio +10 more
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Research Progress on Circular RNA in Glioma
Frontiers in Oncology, 2021 The discovery of circular RNA (circRNA) greatly complements the traditional gene expression theory. CircRNA is a class of non-coding RNA with a stable cyclic structure.
Mengyu Chen, Chunyan Yan, Xihe Zhao
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Cooperation of partially transformed clones: an invisible force behind the early stages of carcinogenesis [PDF]
Royal Society Open Science, 2021 Most tumours exhibit significant heterogeneity and are best described as communities of cellular populations competing for resources. Growing experimental evidence also suggests that cooperation between cancer clones is important as well for the ...
Alessandro Esposito
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Chromatin remodeling protein HELLS is critical for retinoblastoma tumor initiation and progression. [PDF]
, 2020 Retinoblastoma is an aggressive childhood cancer of the developing retina that initiates by biallelic RB1 gene inactivation. Tumor progression in retinoblastoma is driven by epigenetics, as retinoblastoma genomes are stable, but the mechanism(s) that ...
Benavente, Claudia A +8 more
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