Results 11 to 20 of about 80,296 (266)
Oncogene, 2000 Since their discovery as key mediators of cytokine signaling, considerable progress has been made in defining the structure-function relationships of Signal Transducers and Activators of Transcription (STATs). In addition to their central roles in normal cell signaling, recent studies have demonstrated that diverse oncoproteins can activate specific ...
T, Bowman +3 more
openaire +2 more sources
P2X7 Variants in Oncogenesis [PDF]
Cells, 2021 The P2X7 receptor for extracellular ATP is a well-established mediator of tumoral development and progression both in solid cancers and hematological malignancies. The human P2X7 gene is highly polymorphic, and several splice variants of the receptor have been identified in time. P2X7 single-nucleotide polymorphisms (SNPs) have been broadly analyzed by
Pegoraro A., De Marchi E., Adinolfi E.
openaire +4 more sources
PAK signaling in oncogenesis [PDF]
Oncogene, 2009 The p21-activated kinase (PAK) family of serine/threonine kinases is important in physiological processes including motility, survival, mitosis, transcription and translation. PAKs are evolutionally conserved and widely expressed in a variety of tissues and are often overexpressed in multiple cancer types.
Molli, Poonam R. +4 more
openaire +2 more sources
Herpesviruses and Oncogenesis [PDF]
Proceedings of the National Academy of Sciences, 1972 Herpesviruses have been implicated in oncogenesis. They have been found to be etiologic agents in certain chicken, primate, and frog neoplasms. There is suggestive evidence that herpesviruses may contribute to the genesis of certain human lymphomas.
openaire +2 more sources
Polarity proteins in oncogenesis [PDF]
Current Opinion in Cell Biology, 2020 Most human cancers arise from epithelial tissues, which are apical-basally polarized and possess intercellular adhesive junctions. Epithelial cells grow to characteristic densities, often from proliferative progenitors, which arrest as they mature. Homeostatic mechanisms can maintain this characteristic density if it is exceeded (crowding) or is too ...
Maria Fomicheva +2 more
openaire +2 more sources
FEBS Open Bio, 2023 Therapeutic targeting of the transforming growth factor beta (TGFβ) pathway in cancer represents a clinical challenge since TGFβ exhibits either tumor suppressive or tumor promoting properties, depending on the tumor stage.
Matthis Desoteux +9 more
doaj +1 more source
Frontiers in Oncology, 2022 BackgroundProgrammed death receptor-1 (PD-1) blockade shows little benefit in patients with microsatellite-stable colorectal cancer (MSS-CRC). Fruquintinib is a China-made anti-angiogenic drug which is approved for the third line therapy in mCRC.
Qingli Li +8 more
doaj +1 more source
Chromosomal Instability, Aneuploidy, and Gene Mutations in Human Sporadic Colorectal Adenomas
Cellular Oncology, 2004 Whether in vivo specific gene mutations lead to chromosomal instability (CIN) and aneuploidy or viceversa is so far not proven. We hypothesized that aneuploidy among human sporadic colorectal adenomas and KRAS2 and APC mutations were not independent ...
Walter Giaretti +3 more
doaj +1 more source
Oncogenesis, 2012 A very, very long-time ago, way back before there was email, science was communicated in two ways. We would read papers that were actually on paper, bound into journals, and sent to libraries, offices and homes by something called mail (not to be confused with the aforementioned email).
openaire +2 more sources
Cancer Reports, EarlyView., 2023 Abstract Background A methodology to assess the immune microenvironment (IME) of non‐small cell lung cancer (NSCLC) has not been established, and the prognostic impact of IME factors is not yet clear. Aims This study aimed to assess the IME factors and evaluate their prognostic values. Methods and Results We assessed CD8+ tumor‐infiltrating lymphocyte (
Yukihiro Terada +16 more
wiley +1 more source