Results 31 to 40 of about 80,296 (266)
Control of Protein Homeostasis in the Early Secretory Pathway: Current Status and Challenges
Cells, 2019 : Discrimination between properly folded proteins and those that do not reach this state is necessary for cells to achieve functionality. Eukaryotic cells have evolved several mechanisms to ensure secretory protein quality control, which allows ...
Daria Sicari, Aeid Igbaria, Eric Chevet
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ABCC9 Is Downregulated and Prone to Microsatellite Instability on ABCC9tetra in Canine Breast Cancer
Frontiers in Veterinary Science, 2022 Tumorigenesis is associated with metabolic abnormalities and genomic instability. Microsatellite mutations, including microsatellite instability (MSI) and loss of heterozygosity (LOH), are associated with the functional impairment of some tumor-related ...
Pan Hao +5 more
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Cooperation of partially transformed clones: an invisible force behind the early stages of carcinogenesis [PDF]
Royal Society Open Science, 2021 Most tumours exhibit significant heterogeneity and are best described as communities of cellular populations competing for resources. Growing experimental evidence also suggests that cooperation between cancer clones is important as well for the ...
Alessandro Esposito
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Research Progress on Circular RNA in Glioma
Frontiers in Oncology, 2021 The discovery of circular RNA (circRNA) greatly complements the traditional gene expression theory. CircRNA is a class of non-coding RNA with a stable cyclic structure.
Mengyu Chen, Chunyan Yan, Xihe Zhao
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Kaposi Sarcoma, a Trifecta of Pathogenic Mechanisms
Diagnostics, 2022 Kaposi’s sarcoma is a rare disease with four known variants: classic, epidemic, endemic and iatrogenic (transplant-related), all caused by an oncogenic virus named Human Herpes Virus 8.
Gabriela Rusu-Zota +5 more
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Nature Communications, 2017 Cancer genomic data sets contain a wealth of data that can be used to predict prognosis and further understand disease. Here, the authors integrate multiple genomics data types to identify transcriptional dysregulation in response to somatic mutations.
Hatice U. Osmanbeyoglu +4 more
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The role of Plk3 in oncogenesis [PDF]
Oncogene, 2015 The polo-like kinases (Plks) encompass a family of five serine/threonine protein kinases that play essential roles in many cellular processes involved in the control of the cell cycle, including entry into mitosis, DNA replication and the response to different types of stress.
C, Helmke, S, Becker, K, Strebhardt
openaire +2 more sources
Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas
Pediatric Blood &Cancer, EarlyView.ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Nicotinamide N-Methyltransferase: An Emerging Protagonist in Cancer Macro(r)evolution
Biomolecules, 2021 Nicotinamide N-methyltransferase (NNMT) has progressed from being considered merely a Phase II metabolic enzyme to one with a central role in cell function and energy metabolism. Over the last three decades, a significant body of evidence has accumulated
Richard B. Parsons, Paul D. Facey
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