Results 1 to 10 of about 80,296 (266)

V5 and GFP Tagging of Viral Gene pp38 of Marek’s Disease Vaccine Strain CVI988 Using CRISPR/Cas9 Editing

Viruses, 2022
Marek’s disease virus (MDV) is a member of alphaherpesviruses associated with Marek’s disease, a highly contagious neoplastic disease in chickens. The availability of the complete sequence of the viral genome allowed for the identification of major genes
Weicheng Li, Yaoyao Zhang, Katy Moffat, Venugopal Nair, Yongxiu Yao   +4 more
doaj   +1 more source

CRISPR-Mediated Gene Activation (CRISPRa) of pp38/pp24 Orchestrates Events Triggering Lytic Infection in Marek’s Disease Virus-Transformed Cell Lines

Microorganisms, 2021
Marek’s disease (MD) is an immunosuppressive and highly contagious lymphoproliferative disease caused by Marek’s disease virus (MDV) in poultry. Lymphoblastoid cell lines (LCLs) generated ex vivo from MD lymphomas are considered excellent models to study
Poornima Roy, Katy Moffat, Venugopal Nair, Yongxiu Yao   +3 more
doaj   +1 more source

Therapeutic approaches targeting CD95L/CD95 signaling in cancer and autoimmune diseases

Cell Death and Disease, 2022
Cell death plays a pivotal role in the maintenance of tissue homeostasis. Key players in the controlled induction of cell death are the Death Receptors (DR).
Vesna Risso, Elodie Lafont, Matthieu Le Gallo   +2 more
doaj   +1 more source

SARS-CoV-2 integral membrane proteins shape the serological responses of patients with COVID-19

iScience, 2021
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has elicited a unique mobilization of the scientific community to develop efficient tools to understand and combat the infection.
Sophie Martin, Christopher Heslan, Gwénaële Jégou, Leif A. Eriksson, Matthieu Le Gallo, Vincent Thibault, Eric Chevet, Florence Godey, Tony Avril   +8 more
doaj   +1 more source

Targeting depletion of myeloid-derived suppressor cells potentiates PD-L1 blockade efficacy in gastric and colon cancers

OncoImmunology, 2022
Myeloid-derived suppressor cells (MDSCs) have been demonstrated to suppress antitumor immunity and induce resistance to PD-1/PD-L1 blockade immunotherapy in gastric and colon cancer patients.
Yao Tang, Cong Zhou, Qingli Li, Xiaojiao Cheng, Tinglei Huang, Fuli Li, Lina He, Baiweng Zhang, Shuiping Tu   +8 more
doaj   +1 more source

Genomic characteristics and clinical significance of CD56+ circulating tumor cells in small cell lung cancer

Scientific Reports, 2023
Circulating tumor cells (CTC) have been studied in various solid tumors but clinical utility of CTC in small cell lung cancer (SCLC) remains unclear. The aim of the CTC-CPC study was to develop an EpCAM-independent CTC isolation method allowing isolation
Charles Ricordel, L. Chaillot, E. I. Vlachavas, M. Logotheti, A. Jouannic, T. Desvallees, G. Lecuyer, M. Aubry, G. Kontogianni, C. Mastrokalou, F. Jouan, U. Jarry, R. Corre, Y. Le Guen, T. Guillaudeux, H. Lena, A. Chatziioannou, Rémy Pedeux   +17 more
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The von Willebrand factor stamps plasmatic extracellular vesicles from glioblastoma patients

Scientific Reports, 2021
Glioblastoma is a devastating tumor of the central nervous system characterized by a poor survival and an extremely dark prognosis, making its diagnosis, treatment and monitoring highly challenging.
Quentin Sabbagh, Gwennan André-Grégoire, Carolina Alves-Nicolau, Aurélien Dupont, Nicolas Bidère, Emmanuel Jouglar, Laëtitia Guével, Jean-Sébastien Frénel, Julie Gavard   +8 more
doaj   +1 more source

A genome‐scale CRISPR knock‐out screen in chronic myeloid leukemia identifies novel drug resistance mechanisms along with intrinsic apoptosis and MAPK signaling

Cancer Medicine, 2020
Understanding resistance mechanisms in cancer is of utmost importance for the discovery of novel “druggable” targets. Efficient genetic screening, now even more possible with CRISPR‐Cas9 gene‐editing technology, next‐generation sequencing and ...
Matthieu Lewis, Valérie Prouzet‐Mauléon, Florence Lichou, Elodie Richard, Richard Iggo, Béatrice Turcq, François‐Xavier Mahon   +6 more
doaj   +1 more source

A Distinct Anti-EBV DNase Profile in Patients with Undifferentiated Nasopharyngeal Carcinoma Compared to Classical Antigens

Viruses, 2023
Nasopharyngeal cancer (NPC) is a prevalent type of cancer that often takes the form of undifferentiated carcinoma in the Maghreb region. It affects people of all ages.
Hamid Melouli, Abdelhalim Khenchouche, Fouzia Taibi-Zidouni, Dahmani Salma, Nassim Aoudia, Djamel Djennaoui, Tewfik Sahraoui, Samir Benyahia, Fatima Zohra El Kebir   +8 more
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Tumor analysis: freeze–thawing cycle of triple-negative breast cancer cells alters tumor CD24/CD44 profiles and the percentage of tumor-infiltrating immune cells

BMC Research Notes, 2018
Objective The use of novel methods to characterize living tumor cells relies on well-conceived biobanks. Herein, we raised the question of whether the composition of fresh and freeze/thawed dissociated tumor samples is comparable in terms of quantitative
Matthieu Le Gallo, Thibault de la Motte Rouge, Amanda Poissonnier, Vincent Lavoué, Patrick Tas, Jean Leveque, Florence Godey, Patrick Legembre   +7 more
doaj   +1 more source