Results 101 to 110 of about 41,863 (260)

Oncogenic Viruses [PDF]

The American Journal of the Medical Sciences, 1962
  +6 more sources

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

Spindle Cell Neoplasm with Hyperbilirubinemia in a Renal Transplant Recipient: A Rare Case Report

Turkish Journal of Nephrology, 2019
The risk of neoplasm increases after transplantation in patients with organ transplantation. Immunosuppressive treatments or oncogenic viruses are major risk factors. Epstein-Barr virus (EBV) and Human Herpesvirus-8 (HHV-8) are the most frequently shown
Ayşenur ÇIRAK, Eray EROĞLU, İsmail KOÇYİĞİT, Kemal DENİZ, Ö. İbrahim KARAHAN, Aydın ÜNAL, Murat SİPAHİOĞLU, Bülent TOKGÖZ, Oktay OYMAK   +8 more
doaj  

Cholesterol‐Mediated Metabolic‐mechanotransductive Crosstalk Orchestrates Castration Resistance in Prostate Cancer

Advanced Science, EarlyView.
Full androgen deprivation (FAD) induces paracrine cholesterol in prostate cancer that drives the polarization of cancer‐associated fibroblasts (CAFs) and subsequent elevated matrix stiffness. Matrix stiffness in turn potentiates tumor cell survival under FAD pressure via dual mechanotransductive activation of the IRE1α‐XBP1s stress‐response axis ...
Shaojie Liu, Chao Xu, Jun Jiang, Limin He, Yike Zhou, Zhengxuan Li, Yu Li, Keying Zhang, Fa Yang, Tong Lu, Hongtao Song, Hai Zhu, Zhihao Hu, Xiaolong Zhao, Kai Gan, Hongji Li, Bo Yang, Rui Zhang, Weihong Wen, Donghui Han, Weijun Qin   +20 more
wiley   +1 more source

Surfaceome Reprogramming of Stemsomes Promotes Lung Cancer Targeting via Potentiated Receptor–Ligand Interactions

Advanced Science, EarlyView.
This study presents a surfaceome‐reprogramming strategy for mutation‐independent lung cancer therapy by repurposing dexamethasone to prime mesenchymal stem cell‐derived nanovesicles. The engineered vesicles leverage multi‐valent interactions mediated by upregulated adhesion proteins, EPHA2, and NOTCH3.
Geunhye Kim, In Ah Kwon, Bo Seop Jeong, Hyo Seon Kim, Joo‐Hwan Park, Sung Jean Park, Sang‐Rae Lee, Youngki Lee, Dongwoo Khang   +8 more
wiley   +1 more source

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan, Qian Zheng, Deng Liu, Ruichao Nie, Menglin Yao, Xiaolong Tang, Renjie Xu, Jinghong Xian, Wenjun Meng, Wenxin Luo, Dan Liu, Guiyi Ji   +11 more
wiley   +1 more source

Detection of oncogenic DNA viruses in colorectal cancer

, 2008
As a part of our search for oncogenic viruses as potential etiological agents in human malignancies, our studies on human papillomaviruses (HPV) were extended to analysis of the 3 polyomaviruses (SV40, BKV and JCV) in colorectal ...
Syrjänen, K, FAVALLI, CARTESIO, PERNO, CARLO FEDERICO, Ronci, C, Ciotti, M, Di Bonito, L, Ciotti, M., Giuliani, L, Favalli, C, Perno, C, Bonifacio, D   +10 more
core  

Mechanisms of apoptosis regulation and antiapoptotic action of oncogenic viruses

, 2000
В обзоре анализируются молекулярные механизмы индукции и блокирования апоптоза. Обсужда­ются различные антиапоптические эффекты онкогенных вирусов, что обеспечивает продление жизни инфицированных и злокачественно трансформированных клеток ...
Бутенко, З.А., Фильченков, А.А.   +1 more
core   +1 more source

HLA‐DR+ Schwann Cells Generate the Protumor Cancer‐Neuron‐Immune Niche in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
Hijacked and educated by HNSCC cells, HLA‐DR+ Schwann cells lost their normal neural‐related functions but acquired immunoregulatory phenotypes to promote CD4+ T cells transform into Tregs. HLA‐DR+ Schwann cells induced a macrophage subpopulation, Il1β.
Xiaoyan Meng, Zhonglong Liu, Shijian Zhang, Luoman Gan, Liren Cao, Jingjing Sun, Lingfang Zhang, Yue He   +7 more
wiley   +1 more source

Epigenetic and epitranscriptomic regulation during oncogenic γ-herpesvirus infection

Frontiers in Microbiology
Oncogenic gamma herpesviruses, including Epstein–Barr Virus (EBV) and Kaposi’s Sarcoma-associated Herpesvirus (KSHV), are opportunistic cancer-causing viruses and induces oncogenesis through complex mechanisms, which involves manipulation of cellular ...
Rajnish Kumar Singh, Ramakrishna Vangala, Atharva S. Torne, Dipayan Bose, Erle S. Robertson   +4 more
doaj   +1 more source