Results 51 to 60 of about 1,168,324 (310)

Prevention of venous thromboembolic complications in oncological surgery (review of the literature)

Вестник хирургии имени И.И. Грекова, 2020
The multifactorial nature of the problem of venous thromboembolic complications (VTEC) in oncological surgery underlies that, despite the widespread introduction of risk criteria and routine thromboprophylaxis in practice, it is not possible to ...
A. M. Karsanov, A. A. Kulchiev, A. K. Khestanov, A. A. Morozov, S. V. Tigiev   +4 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Hartmann’s operation: 100 years in surgery

Вестник хирургии имени И.И. Грекова, 2020
The first idea of stage operations for colon cancer was introduced in 1898 by G. F. Ceidler. The first stage of treatment, he recommended the formation of colostoma above the tumor.
A. A. Kurygin, V. V. Semenov, I. S. Tarbaev   +2 more
doaj   +1 more source

Exploration of modified progression-free survival as a novel surrogate endpoint for overall survival in immuno-oncology trials [PDF]

, 2021
Zixian Wang, Hao‐Xiang Wu, Li Xie, Wu‐Hao Lin, Fei Liang, Jin Li, Zhimin Yang, Rui‐Hua Xu   +7 more
openalex   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Genetic Polymorphisms Associated with Vincristine Pharmacokinetics and Vincristine-Induced Peripheral Neuropathy in Pediatric Oncology Patients [PDF]

, 2022
Mirjam E. van de Velde, Aniek Uittenboogaard, Wenjian Yang, Erik Bonten, Cheng Cheng, Deqing Pei, M. van den Berg, Inge M. van der Sluis, Cor van den Bos, Floor Abbink, Marry M. van den Heuvel‐Eibrink, Heidi Segers, Christophe Chantrain, Jutte van der Werff ten Bosch, Leen Willems, William E. Evans, Gertjan J.L. Kaspers   +16 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Elective Tracheostomy in Head and Neck Surgery: Our Experience [PDF]

Journal of Clinical and Diagnostic Research, 2017
Introduction: Tracheostomy is commonly used to secure the airway during the immediate postoperative period in maxillofacial oncological operations. We conducted a study to review the utility of elective tracheostomy in head and neck surgery.
Venkatesh S Anehosur, Pallavi Karadiguddi, Vajendra K Joshi, Basavraj C Lakkundi, Rajarshi Ghosh, Gopalkrishnan Krishnan   +5 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Theory and practice of clinical trials in oncology and hematology

Онкогематология, 2016
In the era of evidence-based medicine the main reason for the implementation of new treatment methods are the results of clinical trials. However, clinical trials is a separate area of knowledge, which is often little known to clinicians, that does not ...
N. V. Zhukov
doaj   +1 more source