Results 111 to 120 of about 4,767 (196)

Thymopentin enhances adenoviral oncolytic therapy by regulating macrophages and CD8+ T cells

Communications Medicine
Background Oncolytic viruses are cancer therapies that selectively replicate in tumors, deliver therapeutic genes, and stimulate immune responses. Combining these viruses with immune-boosting agents could enhance their effectiveness.
Lingkai Kong, Kua Liu, Yan Liu, Huawei Cui, Peng Wang, Jiannan Qiu, Qilei Xin, Dan Zhou, Wencui Liu, Fangkun Zhao, Junnan Wu, Xiaosong Gu, Junhua Wu, Chunping Jiang   +13 more
doaj   +1 more source

Oncolytic vaccinia virus: a silver bullet? [PDF]

Expert Review of Vaccines, 2010
Monika, Lusky, Philippe, Erbs, Johann, Foloppe, R Bruce, Acres   +3 more
openaire   +2 more sources

Vaccinia Virus Shuffling: deVV5, a Novel Chimeric Poxvirus with Improved Oncolytic Potency

, 2018
Oncolytic virus (OV) therapy has emerged as a promising approach for cancer treatment with the potential to be less toxic and more efficient than classic cancer therapies.
Marine Ricordel, Eric Quemeneur, Pascale Cordier, Benoit Grellier, Juliette Kempf, Delphine Antoine, Philippe Erbs, Annie Findeli, Johann Foloppe, Monika Lusky, Aude Gerbaud   +10 more
core   +1 more source

Viruses as nanomedicine for cancer

International Journal of Nanomedicine, 2016
Narayanasamy Badrinath,1 Jeong Heo,2 So Young Yoo1,3 1BIO-IT Foundry Technology Institute, 2Department of Internal Medicine, College of Medicine, Medical Research Institute, Pusan National University, Busan, 3Research Institute for Convergence of ...
Badrinath N, Heo J, Yoo SY
doaj  

Temporal expression classes and functions of vaccinia virus and mpox (monkeypox) virus genes

mBio
Poxviruses comprise pathogens that are highly pathogenic to humans and animals, causing diseases such as smallpox and mpox (formerly monkeypox). The family also contains members developed as vaccine vectors and oncolytic agents to fight other diseases ...
Yining Deng, Santiago Navarro-Forero, Zhilong Yang   +2 more
doaj   +1 more source

Utilizing oncolytic vaccinia virus to modulate the tumor microenvironment

Oncolytic viruses are viruses which lyse tumor cells and stimulate a patient specific anti-tumor and anti-viral immune response. While one oncolytic virus has received FDA approval, clinical success has been limited.
DePeaux, Kristin
core  

Combination Radiation Therapy and Oncolytic Vaccinia Virus Therapy in Preclinical Models of Glioma

, 2017
Gliomas are the most common primary malignant brain tumour in adults, with glioblastoma multiforme (GBM), the most common and most deadly form of glioma, making up over half of all diagnosed cancers in the brain/central nervous system.
Fung, Rachel D
core   +1 more source

Designing the Next-generation Oncolytic Vaccinia Virus

, 2017
Many oncolytic viruses (OVs), such as double-deleted vaccina virus (vvDD), are engineered with enhanced tumor-selectivity based on increased cell proliferation in cancer cells. We proposed that OVs with improved tumor efficacy and equal tumor-selectivity
Ho, Tiffany Yun-Yee
core   +1 more source

Oncolytic vaccinia virus as a precision cancer vaccine platform

Oncolytic viruses (OVs) are a unique immunotherapeutic tool as they possess the ability to selectively replicate in and kill tumor cells while also having the potential to induce potent anti-tumor immune responses. Further, the use of OVs as payload delivery systems to the tumor offers a precision approach to enhancing immune responses generated during
Shae J Komant, Jun Li Wang, Nicole Favis, Cyril Alex, David H Evans, Ryan S Noyce, Troy A Baldwin   +6 more
openaire   +1 more source

Rational engineering of microRNA-regulated viruses for cancer gene therapy

, 2013
MicroRNAs (miRNAs) are small noncoding RNA molecules that have important regulatory roles in a wide range of biological processes. miRNAs are often expressed in a tissue- and/or differentiation state-specific patterns, and it is estimated that miRNAs can
Ylösmäki, Erkko
core