Results 121 to 130 of about 4,767 (196)

Vaccinia Virus Converts Microglia into Potent Oncolytic Agent for Glioblastoma and Neuroblastoma

Cells
Background: Glioblastoma and neuroblastoma are aggressive brain and pediatric tumors with limited treatment options. Vaccinia virus (VV) has demonstrated potent oncolytic and immunomodulatory properties but faces challenges in tumor targeting. Methods: We developed an in vitro co-culture model using mouse microglia (BV2) infected with VV (LIVP strain ...
Elena Ekrami, Parisa Ghanbari, Eman M. Othman, Aladar A. Szalay   +3 more
openaire   +2 more sources

Oncolytic Vaccinia Virus TG6002 [PDF]

, 2020
openaire   +1 more source

Oncolytic Vaccinia Virus-Engineered EVs Convert Tumor-Promoting Macrophages into Anti-Tumor Effectors. [PDF]

Cancer Manag Res
Chen L, Ye L, Bao L, Wang J, Tan M.
europepmc   +1 more source

An oncolytic vaccinia virus encoding CD47 nanobody potentiates antitumor immunity in multiple myeloma. [PDF]

iScience
Pan L, Zhu X, Zhang J, Zhong Q, Wu H, Sun W, Xia Y, Wang S, Tong X.   +8 more
europepmc   +1 more source

IL-18-armed oncolytic vaccinia virus remodels the suppressive microenvironment via macrophage and Treg modulation in lymphoma. [PDF]

Cancer Immunol Immunother
Wu H, Zhang J, Xu L, Xie Y, Pan L, Zhang X, Xia Y, Yang F, Kang X, Tong X, Wang S.   +10 more
europepmc   +1 more source

Intratumoral PD-1-directed IL-2 expression via oncolytic vaccinia virus elicits superior antitumor effects with enhanced safety. [PDF]

J Immunother Cancer
Chen L, Ye J, Patel S, Ming P, Li C, Waltermire J, Zhao J, Ren J, Bartlett DL, Liu Z.   +9 more
europepmc   +1 more source

Oncolytic vaccinia virus encoding constitutively active EPAC remodels the tumor microenvironment to enhance therapeutic efficacy with chemotherapy and surgery. [PDF]

J Immunother Cancer
Boulton S, Singh S, Organ B, Thomas J, Rezaei R, Gill R, Vallati S, Guo Q, Dave J, Petryk J, De Souza CT, Austin B, He X, Gingrich A, Crupi MJF, Singaravelu R, Ilkow C, Bell JC.   +17 more
europepmc   +1 more source

[Corrigendum] Gemcitabine combined with an engineered oncolytic vaccinia virus exhibits a synergistic suppressive effect on the tumor growth of pancreatic cancer. [PDF]

Oncol Rep
Chen W, Fan W, Ru G, Huang F, Lu X, Zhang X, Mou X, Wang S.   +7 more
europepmc   +1 more source

TG6002 oncolytic vaccinia virus and chemotherapy synergy: a promising strategy for pancreatic ductal adenocarcinoma. [PDF]

Front Microbiol
Foloppe J, Farine I, Pichon C, Kempf J, Hortelano J, Moreau B, Cochin S, Takeda A, Pessaux P, Erbs P.   +9 more
europepmc   +1 more source

Non-Secreted Mature Decoy-Resistant IL-18-Armed Oncolytic Vaccinia Virus Elicits Potent Antitumor Effects in an Aggressive Murine Ovarian Cancer Model. [PDF]

Cancers (Basel)
Ming P, Li C, Ye J, Chen L, Waltermire J, Zhao J, Eid M, Zhang T, Ge W, Ren J, Bartlett DL, Liu Z.   +11 more
europepmc   +1 more source