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Apoptin enhances the oncolytic activity of vaccinia virus in vitro
Molecular Biology, 2013The chicken anemia virus gene that encodes apoptin, a selective killer of cancer cells, was synthe-sized and inserted into the vaccinia virus (strain L-IVP) genome. The insertion replaces a major part of the viral C11R gene that encodes viral growth factor, which is important for virulence. The recombinant virus VVdGF-ApoS24/2 was obtained by transient
G. V. Kochneva +10 more
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[Apoptin enhances the oncolytic activity of vaccinia virus].
Molekuliarnaia biologiia, 2015Chicken anemia virus gene encoding apoptin, a selective killer of cancer cells was synthesized and inserted into vaccinia virus (strain L-IVP) genome. The insertion has replaced major part of the viral C11R gene encoding viral growth factor (VGF), which is important for the virulence.
G V, Kochneva +10 more
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Oncolytic vaccinia virus: from bedside to benchtop and back.
Current opinion in molecular therapeutics, 2008The field of oncolytic viral therapy has undergone a major shift in focus in the last few years. Less research has been directed at making incremental improvements in original vectors based mainly on strains of adenovirus and HSV; instead a variety of different viral strains have been suggested as potential backbones for future oncolytic viruses ...
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Generation of a Novel Oncolytic Vaccinia Virus Using the IHD-W Strain
Human Gene Therapy, 2021Sujeong Kim
exaly