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Pre-made Oncolytic Vaccinia Virus

, 2023
 Among the several types of anti-cancer treatments, Pre-made Oncolytic Vaccinia Virus targets and kills tumor cells only, sparing healthy cells. 
candy swift (14858320)
core   +1 more source

Immunotherapeutic potential of oncolytic vaccinia virus [PDF]

Immunologic Research, 2011
There has recently been resurgence in interest for the use of replication-selective (oncolytic) viruses for the treatment of cancers. This has been fueled by positive clinical data and the promise provided by next-generation vectors that are better targeted and display enhanced therapeutic potential.
openaire   +5 more sources

Oncolytic vaccinia virus synergizes with irinotecan in colorectal cancer [PDF]

Molecular Oncology, 2015
Metastatic colorectal cancer (CRC) is complex clinical challenge for which there are limited treatment options. Chemotherapy with or without surgery provides moderate improvements in overall survival and quality of life; nevertheless the 5‐year survival remains below 30%. Oncolytic vaccinia virus (VV) shows strong anti‐tumour activity in models of CRC,
Kathryn, Ottolino-Perry, Sergio A, Acuna, Fernando A, Angarita, Clara, Sellers, Siham, Zerhouni, Nan, Tang, J Andrea, McCart   +6 more
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Enhancement of vaccinia virus based oncolysis with histone deacetylase inhibitors. [PDF]

PLoS ONE, 2010
Histone deacetylase inhibitors (HDI) dampen cellular innate immune response by decreasing interferon production and have been shown to increase the growth of vesicular stomatitis virus and HSV.
Heather MacTavish, Jean-Simon Diallo, Baocheng Huang, Marianne Stanford, Fabrice Le Boeuf, Naomi De Silva, Julie Cox, John Graydon Simmons, Tanya Guimond, Theresa Falls, J Andrea McCart, Harry Atkins, Caroline Breitbach, David Kirn, Stephen Thorne, John C Bell   +15 more
doaj   +1 more source

Combined anti-tumor efficacy of somatostatin fusion protein and vaccinia virus on tumor cells with high expression of somatostatin receptors

Scientific Reports, 2022
Somatostatin, a growth hormone-release inhibiting peptide, exerts antiproliferative and antiangiogenic effects on tumor cells. However, the short half-life of somatostatin limits its application in human therapy, and long-acting somatostatin fusion ...
Jun Fan, Lili Deng, Ying Peng, Yuedi Ding   +3 more
doaj   +1 more source

Cell cycle progression or translation control is not essential for vesicular stomatitis virus oncolysis of hepatocellular carcinoma. [PDF]

, 2010
The intrinsic oncolytic specificity of vesicular stomatitis virus (VSV) is currently being exploited to develop alternative therapeutic strategies for hepatocellular carcinoma (HCC). Identifying key regulators in diverse transduction pathways that define
Enrico N. De Toni, Jennifer Altomonte, Roland M Schmid, Schneider, Günter, Schmid, Roland M., Rizzani Antonia, Thasler Wolfgang E., Ebert Oliver, Thasler, Wolfgang E., Schmid Roland M., Marozin, Sabrina, De Toni, Enrico N., Kato, Nobuyuki, Marozin Sabrina, Wolfgang E Thasler, Wolfgang E. Thasler, Enrico N De Toni, Altomonte, Jennifer, Alexandra Junger, De Toni Enrico N., Altomonte Jennifer, Ebert, Oliver, Günter Schneider, Oliver Ebert, Sabrina Marozin, Junger Alexandra, Kato Nobuyuki, Roland M. Schmid, Junger, Alexandra, Schneider Günter, Nobuyuki Kato, Rizzani, Antonia, Antonia Rizzani   +32 more
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CCL5-armed oncolytic virus augments CCR5-engineered NK cell infiltration and antitumor efficiency

Journal for ImmunoTherapy of Cancer, 2020
Background Natural killer (NK) cells have potent antitumor activities. Nevertheless, adoptive transfer therapy of NK cells has gained very limited success in patients with solid tumors as most infused NK cells remain circulating in the peripheral blood ...
Yi Zhang, Feng Li, Yuqiao Sheng, Weizhou Hou, Padma Sampath, Daniel Byrd, Stephen Thorne   +6 more
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Polymeric Cups for Cavitation-mediated Delivery of Oncolytic Vaccinia Virus [PDF]

Molecular Therapy, 2016
Oncolytic viruses (OV) could become the most powerful and selective cancer therapies. However, the limited transport of OV into and throughout tumors following intravenous injection means their clinical administration is often restricted to direct intratumoral dosing.
Myers, R, Coviello, C, Erbs, P, Foloppe, J, Rowe, C, Kwan, J, Crake, C, Finn, S, Jackson, E, Balloul, J, Story, C, Coussios, C, Carlisle, R   +12 more
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Antitumor activity of recombinant oncolytic vaccinia virus with human IL2

Open Medicine, 2022
Abstract The tumor microenvironment is highly immunosuppressive. The genetically modified oncolytic vaccinia virus (OVV) is a promising vector for cancer immunotherapy. The aim of the present study was to assess the antitumor effects of human interleukin-2 (hIL2)-armed OVV in vitro.
Liu Liqiong, Li Huiqun, Xu Qinggang, Wu Yan, Chen Dongfeng, Yu Feng   +5 more
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Antitumor efficacy of cytosine deaminase-armed vaccinia virus plus 5-fluorocytosine in colorectal cancers

Cancer Cell International, 2020
Background Vaccinia viruses have emerged as attractive therapeutic candidates for cancer treatment due to their inherent ability of tumor tropism and oncolytic property.
Yuedi Ding, Jun Fan, Lili Deng, Biao Huang, Bin Zhou   +4 more
doaj   +1 more source