Results 11 to 20 of about 4,767 (196)

Virotherapy of canine tumors with oncolytic vaccinia virus GLV-1h109 expressing an anti-VEGF single-chain antibody. [PDF]

PLoS ONE, 2012
Virotherapy using oncolytic vaccinia virus (VACV) strains is one promising new strategy for cancer therapy. We have previously reported that oncolytic vaccinia virus strains expressing an anti-VEGF (Vascular Endothelial Growth Factor) single-chain ...
Sandeep S Patil, Ivaylo Gentschev, Marion Adelfinger, Ulrike Donat, Michael Hess, Stephanie Weibel, Ingo Nolte, Alexa Frentzen, Aladar A Szalay   +8 more
doaj   +2 more sources

Vaccinia virus-based vector against infectious diseases and tumors

Human Vaccines & Immunotherapeutics, 2021
Vaccinia virus was used to prevent smallpox. After the World Health Organization declared smallpox extinct, vaccinia virus has been explored for the development of vaccines against a variety of infectious diseases.
Ziling Zhang, Lanlan Dong, Chen Zhao, Peiyong Zheng, Xiaoyan Zhang, Jianqing Xu   +5 more
doaj   +2 more sources

Construction of three strains of recombinant oncolytic vaccinia virus and their anti-tumor activity [PDF]

Jichu yixue yu linchuang, 2020
Objective The aim of this study is to construct a recombinant oncolytic vaccinia virus with CCL5 and SSTR2 genes and to detect its antitumor activity. Methods Recombinant vaccinia virus eukaryotic expression plasmid pSC65-CCL5-SSTR2-Luc+ was constructed.
LI Dan-yang, FANG Jing-jing, TANG Hui
doaj   +1 more source

Generation of novel oncolytic vaccinia virus with improved intravenous efficacy through protection against complement-mediated lysis and evasion of neutralization by vaccinia virus-specific antibodies

Journal for ImmunoTherapy of Cancer, 2023
Background Oncolytic virus immunotherapy has revolutionized cancer immunotherapy by efficiently inducing both oncolysis and systemic immune activation.
Dong-Sup Lee, Mi-Ju Park, Namhee Lee, Yun-Hui Jeon, Jiyoon Yoo, Suk-kyung Shin, Songyi Lee, Byung-Jin Jung, Yun-Kyoung Hong, Keunhee Oh   +9 more
doaj   +2 more sources

Evaluation of a new recombinant oncolytic vaccinia virus strain GLV-5b451 for feline mammary carcinoma therapy. [PDF]

PLoS ONE, 2014
Virotherapy on the basis of oncolytic vaccinia virus (VACV) infection is a promising approach for cancer therapy. In this study we describe the establishment of a new preclinical model of feline mammary carcinoma (FMC) using a recently established cancer
Marion Adelfinger, Ivaylo Gentschev, Julio Grimm de Guibert, Stephanie Weibel, Johanna Langbein-Laugwitz, Barbara Härtl, Hugo Murua Escobar, Ingo Nolte, Nanhai G Chen, Richard J Aguilar, Yong A Yu, Qian Zhang, Alexa Frentzen, Aladar A Szalay   +13 more
doaj   +3 more sources

Expression of CCL19 from Oncolytic Vaccinia Enhances Immunotherapeutic Potential while Maintaining Oncolytic Activity

Neoplasia: An International Journal for Oncology Research, 2012
Promising phase II clinical results have been reported recently for several oncolytic viral therapeutics, including strains based on vaccinia virus. One reason for this has been an increased appreciation of the critical therapeutic importance of the ...
Jun Li, Mark O'Malley, Padma Sampath, Pawel Kalinski, David L. Bartlett, Steve H. Thorne   +5 more
doaj   +2 more sources

A novel oncolytic vaccinia virus with multiple gene modifications involved in viral replication and maturation increases safety for intravenous administration while maintaining proliferative potential in cancer cells. [PDF]

PLoS ONE
To generate a novel oncolytic vaccinia virus with improved safety and productivity, the genome of smallpox vaccine strain LC16m8 was modified by a bacterial artificial chromosome system. By using LC16m8, a replicating virus homologous to the target virus,
Go Okita, Kiyotaka Suenaga, Masashi Sakaguchi, Toshio Murakami   +3 more
doaj   +2 more sources

Haliotis discus discus Sialic Acid-Binding Lectin Reduces the Oncolytic Vaccinia Virus Induced Toxicity in a Glioblastoma Mouse Model

Marine Drugs, 2018
Although oncolytic viruses provide attractive vehicles for cancer treatment, their adverse effects are largely ignored. In this work, rat C6 glioblastoma cells were subcutaneously xenografted into mice, and a thymidine kinase-deficient oncolytic vaccinia
Gongchu Li, Shengsheng Mei, Jianhong Cheng, Tao Wu, Jingjing Luo   +4 more
doaj   +2 more sources

Advances of oncolytic vaccinia viruses armed with interleukin in tumor therapy [PDF]

Frontiers in Oncology
Oncolytic vaccinia viruses armed with interleukins represent a promising frontier in tumor therapy. Oncolytic vaccinia viruses express IL-2, IL-10, IL-12, IL-15, IL-21, IL-23, IL-24, and IL-36γ remodel the tumor microenvironment,enhance immune cell ...
Mingyong Zha, Fei Huang, Songlin Li, Qi Wang, Qi Wang, Qi Wang, Yong Tang, Yong Tang, Yong Tang   +8 more
doaj   +2 more sources

Preclinical evaluation of oncolytic vaccinia virus for therapy of canine soft tissue sarcoma. [PDF]

PLoS ONE, 2012
Virotherapy using oncolytic vaccinia virus (VACV) strains is one promising new strategy for canine cancer therapy. In this study we describe the establishment of an in vivo model of canine soft tissue sarcoma (CSTS) using the new isolated cell line STSA ...
Ivaylo Gentschev, Marion Adelfinger, Rafael Josupeit, Stephan Rudolph, Klaas Ehrig, Ulrike Donat, Stephanie Weibel, Nanhai G Chen, Yong A Yu, Qian Zhang, Martin Heisig, Douglas Thamm, Jochen Stritzker, Amy Macneill, Aladar A Szalay   +14 more
doaj   +2 more sources