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Recent Patents in Oncolytic Virotherapy
Recent Patents on Biotechnology, 2016Recent innovative and advanced developments in the diagnosis and treatment of human diseases as well as enhanced in-depth understanding of virus molecular biology have opened novel avenues with respect to the patent landscape. Included are viruses utilized in the development of anticancer agents, agents that are employed against the spread of ...
Tauqeer, Ahmad +3 more
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Oncolytic virotherapy of gynecologic malignancies
Gynecologic Oncology, 2011Gynecologic cancer is still the third leading cause of cancer death among women in the US. Therapeutics employing novel mechanisms of action are therefore urgently needed. Oncolytic viruses (OVs) selectively infecting and replicating in cancer cells have recently attracted considerable interest as promising anti-cancer agents.
Andreas D, Hartkopf +3 more
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Mathematical Modeling of Oncolytic Virotherapy
2019Mathematical modeling in biology has a long history as it allows the analysis and simulation of complex dynamic biological systems at little cost. A mathematical model trained on experimental or clinical data can be used to generate and evaluate hypotheses, to ask "what if" questions, and to perform in silico experiments to guide future experimentation
Johannes P W, Heidbuechel +3 more
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Oncolytic virotherapy of breast cancer
Gynecologic Oncology, 2011The use of replication competent viruses that selectively target and destroy cancer cells has rapidly evolved over the past decade and numerous innovative oncolytic viruses have been created. Many of these promising anti-cancer agents have recently entered into clinical trials (including those on breast cancer) and demonstrated encouraging safety and ...
Andreas D, Hartkopf +3 more
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What is oncolytic virotherapy?
Archives of disease in childhood - Education & practice edition, 2017It has long been hypothesised that viruses may have a role in treating cancer. From the mid-1800s, there has been documentation of patients undergoing spontaneous cancer remission following severe infection, and by the start of the 20th century, a temporary complete remission of acute leukaemia was observed in a patient suffering from influenza.1 Over ...
Julia V, Cockle, Karen J, Scott
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Immunomodulation in Oncolytic Measles Virotherapy
2019With the recognition of oncolytic virotherapy as an immunotherapy, the distinct interactions between oncolytic agents and the immune system have come into focus. The role of the immune system in oncolytic virotherapy is somewhat ambiguous: While preexisting or arising immunity directed against viral antigens may preclude efficient viral replication and
Laura, Dietz, Christine E, Engeland
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Combining oncolytic virotherapy and tumour vaccination
Cytokine & Growth Factor Reviews, 2010The interactions between the immune system, a malignant tumour and an oncolytic virus are complex and poorly understood. For oncolytic viruses to become successful therapeutics we need to better understand these interactions and identify strategies to take advantage of defects in the innate immune response within tumours and avoid cellular anti-viral ...
Byram W, Bridle +2 more
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Oncolytic Virotherapy of Cancer
2010It has been almost two decades since the first genetically engineered oncolytic virus was reported in 1991. Since then, many novel strategies have been developed to further improve oncolytic virus tumor selectivity and antitumoral potency, which are the two most important factors that would eventually determine the clinical safety and efficacy of any ...
Nanhai G. Chen, Aladar A. Szalay
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Oncolytic virotherapy: new strategies in oncology
Orvosi Hetilap, 2007Az emberi megbetegedések kezelésére kifejlesztett újszerű gyógymódok gyakorlati bevezetése nem egyszerű feladat. Egyrészt a modern terápiák számos kritériumnak kell hogy megfeleljenek, másrészt gyakorta szélsőséges várakozásokat kell kielégíteniük; a betegek és terapeuták euforikus hangulatát a kezdeti nehézségeket követően könnyen válthatja az új ...
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Oncolytic virotherapy for neuroblastoma.
Discovery medicine, 2011Metastatic neuroblastoma (NB) remains a clinical challenge for pediatric oncologists. Overall survival rates stay less than 40% despite intensive multimodal therapy, with the toll of toxicity being related to high-dose chemotherapy. These rates have shown minor improvements over the last years, and the development of newer therapeutic strategies is ...
Manuel, Ramírez +2 more
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