Results 51 to 60 of about 37,441 (280)

Quantitative prediction of intravenous drug interactions caused by cytochromes P450 inhibitors and inducers

British Journal of Clinical Pharmacology, EarlyView.
Background Aims Pharmacokinetic interaction studies typically focus on oral administration, but intravenous (IV) administration bypasses intestinal degradation and hepatic first‐pass metabolism, leading to distinct drug–drug interaction (DDI) magnitude. This study aimed to develop a predictive model for DDIs involving IV‐administered drugs.
Vianney Tuloup, Michel Tod, Laurent Bourguignon   +2 more
wiley   +1 more source

Day-case management of chronic suppurative otitis media with cholesteatoma with canal wall down technique surgery: long-term follow-up [PDF]

, 2017
The overall number of day-case otologic surgery cases is increasing; however, there is limited experience about performing canal wall down tympanoplasty in patients with chronic suppurative otitis media with cholesteatoma in this setting.
GRASSO, MICHELE, NOLA, GIUSEPPE, RALLI, Giovanni, RALLI, MASSIMO, TAGLIONI, ALBERTO   +4 more
core   +2 more sources

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 Genotype and Use of 5‐HT3 Receptor Antagonists: 2026 Update

Clinical Pharmacology &Therapeutics, EarlyView.
5‐hydroxytryptamine type 3 (5‐HT3) receptor antagonists are used to treat nausea and vomiting and in the prevention of chemotherapy‐induced, radiation‐induced, and postoperative nausea and vomiting. Most of the 5‐HT3 receptor antagonists (i.e., ondansetron, tropisetron, dolasetron, palonosetron, and ramosetron) are metabolized by CYP2D6, but the extent
Claire Moore, Melissa S. Bourque, Andreas Halman, José A. G. Agúndez, Cynthia A. Prows, Keiko Hikino, Matthias Schwab, Carolyn J. Oxencis, Dharmisha Chauhan, Meta H.M. Diekstra, Susie E. Long, Gillian C. Bell, Andrea Gaedigk, Michelle Whirl‐Carrillo, Teri E. Klein, Kelly E. Caudle, Rachel Conyers   +16 more
wiley   +1 more source

The Increased Incidence of Nausea and Vomiting Due to Anxiety in Paclitaxel Carboplatin Chemotherapy in a 48 Years Old Female Patient with Cervical Cancer: a Case Report [PDF]

, 2014
Nausea and vomiting was the frequently side effects in chemotherapy.Uncontrolled nausea and vomiting can cause weakened body condition, reduced appetite and drinking, dehydration, electrolyte disturbances, reduced nutritional status so the patient ...
Noviyani, R. (R), Putra, I. F. (I), Suwiyoga, and, K   +2 more
core  

Chemotherapy‐Induced Nausea and Vomiting in Early Breast Cancer Patients Receiving Adjuvant Chemotherapy With Fluorouracil, Epirubicin, Cyclophosphamide Followed by Docetaxel Versus an Anthracycline‐Free Regimen With Docetaxel, Cyclophosphamide—Results From a Randomized Clinical Trial

International Journal of Cancer, EarlyView.
Chemotherapy‐induced nausea and vomiting (CINV) remains a significant clinical problem despite modern antiemetics. In particular, antiemetic strategies for emerging cancer therapies lack detailed evaluation. This randomized trial analyzed hourly CINV data for patients with early breast cancer who received either docetaxel plus cyclophosphamide (TC) or ...
Manuel Hörner, Henning Schäffler, Lothar Häberle, Chloë Goossens, Kerstin Pfister, Elena Leinert, Kristina Veselinovic, Sara Y. Brucker, Uwe Köhler, Georg Heinrich, Andreas Schneeweiss, Matthias W. Beckmann, Peter A. Fasching, Wolfgang Janni, Brigitte Rack, Sabine Heublein, Philipp Ziegler   +16 more
wiley   +1 more source

Anti-dyskinetic efficacy of 5-HT3 receptor antagonist in the hemi-parkinsonian rat model

IBRO Reports, 2019
Parkinson's disease is a progressive debilitative neurodegenerative disease characterised mostly with bradykinesia, tremor, catatonia, drooping posture, unsteady gate and unstable steps.
Nazanin Aboulghasemi, Mahsa Hadipour Jahromy, Amir Ghasemi   +2 more
doaj   +1 more source

Anti-nausea effects and pharmacokinetics of ondansetron, maropitant and metoclopramide in a low-dose cisplatin model of nausea and vomiting in the dog: a blinded crossover study [PDF]

, 2017
Nausea is a subjective sensation which is difficult to measure in non-verbal species. The aims of this study were to determine the efficacy of three classes of antiemetic drugs in a novel low dose cisplatin model of nausea and vomiting and measure change
A Freeman, A Tidholm, AM Holmes, B Otto, C Pirri, C Rojas, CC Horn, CC Horn, CJ Henry, DB Smith, DB Zamble, DG Warr, F Roila, F Roila, FD Tattersall, GJ Sanger, GJ Sanger, GR Morrow, H Fukui, H Fukui, H Kenward, H Kenward, Hannah Kenward, JA Gylys, JA Rudd, Jonathan Elliott, K Olsson, Ludovic Pelligand, LX Cubeddu, M Marty, M Mutoh, N Percie du Sert, N Percie du Sert, PH Mulder De, PJ Hesketh, PJ Hesketh, PL Andrews, RJ Gralla, RM Stern, RM Stern, S Kretzing, S Poli-Bigelli, SG Allan, SP Chawla, Terry Lee, TM Hyde, V Napadow, VA Puente-Redondo de la   +47 more
core   +1 more source

Ultrasound‐Guided Liposomal vs. Conventional Bupivacaine Erector Spinae Plane Block Plus Gabapentin for Postherpetic Neuralgia

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study aimed to compare efficacy and safety of ultrasound‐guided erector spinae plane block (ESPB) using liposomal (LB) versus conventional bupivacaine (CB), each plus standardized gabapentin, in patients with postherpetic neuralgia (PHN). A total of 116 PHN patients were randomized to ESPB‐LB or ESPB‐CB; both groups received standardized ...
Xia‐Jing Xu, Li‐Juan Liu, Fa‐Ming Xu, Xiang‐Yu Fang   +3 more
wiley   +1 more source

Comparison Study of Preemptive Effect of Intratechal Fentanyl with Intravenous Ondansetron, Dexamethasone, and Dexamethasone plus Ondansetron on Shivering during Surgeries under Spinal Anesthesia with Bupivacaine

مجله دانشکده پزشکی اصفهان, 2017
Background: Previous studies showed that dexamethasone and ondansetron had effect on preventing shivering in surgeries under spinal anesthesia but comparison of the two drugs was not studied.
Mohammadreza Safavi, Azim Honarmand, Mina Barzegar   +2 more
doaj  

Alcohol addiction: a molecular biology perspective. [PDF]

, 2015
Alcohol misuse represents worldwide an important risk factor for death and disability. Excessive alcohol consumption is widely diffused in different ethnicities and alcohol use is part of the lifestyle of both young and old people.
Ferraguti, Giampiero, Lucarelli, Marco, Pascale, Esterina   +2 more
core   +1 more source