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One Carbon Metabolism and Mammalian Pregnancy Outcomes
Molecular Nutrition & Food Research, 2020AbstractOne‐carbon metabolism is involved in varieties of physiological processes in mammals, including nucleic acid synthesis, amino acid homeostasis, epigenetic regulation, redox balance and neurodevelopment. The current evidence linking levels of one‐carbon nutrients during pregnancy to the development of oocytes, embryos, and placentas, as well as ...
Shuang Cai +9 more
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Metabolic modulation of transcription: The role of one-carbon metabolism
Cell Chemical Biology, 2022While it is well known that expression levels of metabolic enzymes regulate the metabolic state of the cell, there is mounting evidence that the converse is also true, that metabolite levels themselves can modulate gene expression via epigenetic modifications and transcriptional regulation.
Lin, Jung-Ming G. +5 more
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Serine and one-carbon metabolism in cancer
Nature Reviews Cancer, 2016The non-essential amino acid serine supports several metabolic processes that are crucial for the growth and survival of proliferating cells, including protein, amino acid and glutathione synthesis. As an important one-carbon donor to the folate cycle, serine contributes to nucleotide synthesis, methylation reactions and the generation of NADPH for ...
Ming Yang, Karen H. Vousden
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One-Carbon Metabolism, Spermatogenesis, and Male Infertility
Reproductive Sciences, 2013Balanced diet is the natural source of micronutrients, such as folate and vitamins, vital for proper functioning of the body. One-carbon metabolic pathway along with folate and other vitamins plays an important role in DNA synthesis and in the establishment of epigenetic modifications like DNA/histone methylation.
Kiran, Singh, Deepika, Jaiswal
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Relationships among biomarkers of one-carbon metabolism
Molecular Biology Reports, 2012One-carbon metabolism is a network of metabolic pathways, disruption of which has been associated with cancer and other pathological conditions. Biomarkers of these pathways include homocysteine (HCY), S-adenosylmethionine (SAM), and S-adenosylhomocysteine (SAH).
Will D, King +5 more
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Clinical correlations of one-carbon metabolism abnormalities
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 19881. Ninety psychiatric inpatients with a DSM III diagnosis of schizophrenia, mania, or major depression were studied. 2. Upon admission/transfer to the Clinical Studies Unit, and prior to discharge, measurements of symptom severity (BPRS, Ham-D, Young's Mania Scale) and blood samples were obtained. 3.
Tolbert, Lelland C. +9 more
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Folate-mediated one-carbon metabolism.
Vitamins and hormones, 2008Tetrahydrofolate (THF) polyglutamates are a family of cofactors that carry and chemically activate one-carbon units for biosynthesis. THF-mediated one-carbon metabolism is a metabolic network of interdependent biosynthetic pathways that is compartmentalized in the cytoplasm, mitochondria, and nucleus.
Jennifer T, Fox, Patrick J, Stover
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Formaldehyde regulates one-carbon metabolism and epigenetics
Trends in GeneticsRecently, Pham et al. used an array of model systems to uncover a role for the enzyme methionine adenosyltransferase (MAT)-1A, which is mainly expressed in liver, in both sensing formaldehyde and regulating transcriptional responses that protect against it. This provides a new lens for understanding the effects of formaldehyde on gene regulation.
Marcus J C, Long, Yimon, Aye
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[One-carbon Metabolism and Schizophrenia].
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 2016One-carbon metabolism is a process whereby folate transters one-carbon groups in a range of biological processes, including DNA methylation and homocysteine metabolism. We have focused on and examined the potential roles of this one-carbon metabolism in the pathology of schizophrenia.
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Metabolomics in cancer research and emerging applications in clinical oncology
Ca-A Cancer Journal for Clinicians, 2021Daniel R Schmidt +2 more
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