Results 101 to 110 of about 20,326,114 (289)

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Delta one-carbon metabolism levels in relation to MTX-induced oral mucositis (n = 67).

, 2019
Delta one-carbon metabolism levels in relation to MTX-induced oral mucositis (n = 67).
Bertrand D. van Zelst (7392497), Robert de Jonge (4926013), Marry M. van den Heuvel-Eibrink (7391279), Sandra G. Heil (4044344), Wim J. E. Tissing (7392494), Natanja Oosterom (5492705), Marta Fiocco (387043), Desiree E. C. Smith (7392491), Rob Pieters (294079)   +8 more
core   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Effects of feeding two rumen-protected choline sources during the transition period on performance and blood metabolites of Holstein dairy cows

Italian Journal of Animal Science
This study evaluated the effects of two rumen-protected choline (RPC) sources supplemented to dairy cows from 21 d pre- to 35 d postpartum. Twenty-four multiparous Holstein cows were randomly assigned to three groups (n = 8/group): control (CON ...
V. Sáinz de la Maza-Escolà, F. Piccioli-Cappelli, L. Cattaneo, L. Benedetti, A. Piva, E. Grilli, E. Trevisi   +6 more
doaj   +1 more source

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

FEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada, Takaaki Tanaka, Manaka Uehara, Keigo Nakano, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Masafumi Yohda   +7 more
wiley   +1 more source

Association Between SNPs in the One-Carbon Metabolism Pathway and the Risk of Female Breast Cancer in a Chinese Population

Pharmacogenomics and Personalized Medicine, 2022
Xuhong Wang,1,2,* Mengqiu Xiong,2,* Bei Pan,1,2 William CS Cho,3 Jin Zhou,4 Shukui Wang,1,2,5 Bangshun He2,5 1School of Medicine, Southeast University, Nanjing, Jiangsu Province, 210096, People’s Republic of China; 2Department of Laboratory ...
Wang X, Xiong M, Pan B, Cho WC, Zhou J, Wang S, He B   +6 more
doaj  

The combination model of one-carbon metabolism-related gene polymorphisms between controls and RIF patients.

, 2016
The combination model of one-carbon metabolism-related gene polymorphisms between controls and RIF patients.
Sung Han Shim (141576), Jung Jae Ko (765713), Ji Hyang Kim (555698), Woo Sik Lee (837218), Youngsok Choi (216009), Yubin Lee (3080403), Young Joo Jeon (128378), Nam Keun Kim (128410), Jung Oh Kim (765714)   +8 more
core   +1 more source

Characterization of the key membrane protein cytochrome Cyc2 from Ghiorsea bivora

FEBS Open Bio, EarlyView.
This study reports the first detailed biochemical analysis of Cyc2TAG1_1, a cytochrome protein involved in microbial iron oxidation. We produced and purified this enzyme in E. coli, then measured its iron‐oxidizing efficiency, and characterized its electrical and structural properties.
Josiane Azizi, Alain Dolla, Frauke Baymann, Celine Rommevaux, Latifa Elantak, Helene Gaussier, Matthieu Nouailler   +6 more
wiley   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source