Results 91 to 100 of about 18,461,677 (262)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Spatial coherence properties of one dimensional exciton-polariton condensates [PDF]

, 2014
In this work, we combine a systematic experimental investigation of the power- and temperature-dependent evolution of the spatial coherence function, g(1)(r), in a one dimensional exciton-polariton channel with a modern microscopic numerical theory based
Schneider, C., Savenko, I.G., Shelykh, I.A., Höfling, S., Brodbeck, S., Fischer, J., Holzinger, S., Kamp, M., Fraser, M.D.   +8 more
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Analytical Analysis of Two - Dimensional Consolidation of Soil [PDF]

, 2019
Consolidation is the gradual reduction in volume of a saturated soil due to drainage of some of the pore water, the process continuing until the excess pore water pressure set up by an increase in total stress has completely dissipated; the most common ...
Nwankwo, Ebuka, Osemobor, Ohioze, Aladenika, Adedayo, Iyeke, Solomon   +3 more
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

New observational method for prediction of one-dimensional consolidation settlement

, 2017
The Chapman–Richards model is adopted in this paper to best fit the Terzaghi's one-dimensional consolidation curve. The obtained formula fits the theoretical solution well, with a regression coefficient R2 of 0·9995 and an error of less than 2%.
Guo, Wei, Chu, Jian
core   +1 more source

One-Dimensional Large-Strain Nonlinear Consolidation of Overconsolidated Clays with a Threshold Hydraulic Gradient

Advances in Civil Engineering, 2018
The existence of the threshold hydraulic gradient in clays under a low hydraulic gradient has been recognized by many studies. Meanwhile, most nature clays to some extent exist in an overconsolidated state more or less.
Chuanxun Li, Jinyang Xiao, Yang Yang, Wenbing Wu   +3 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

One-dimensional bargaining with unanimity rule [PDF]

The paper examines bargaining over a one--dimensional set of social states, with a unanimity acceptance rule. We consider a class of delta-equilibria, i.e.
Predtetchinski, Arkadi
core  

Effect of Anisotropy on Compression, Strength and Permeability Properties of Clayey Soil

Tikrit Journal of Engineering Sciences, 2013
Anisotropy on compression, strength and permeability of a clayey soil selected from Mosul city was studied in this paper. Laboratory standard tests were conducted on sets of duplicate disturbed and undisturbed specimens prepared in the vertical, 45º ...
Suhail I. Khyatt, Mohammed N. Al-Zaidy
doaj   +1 more source