Results 71 to 80 of about 56,604 (307)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

One-dimensional test problems for dynamic consolidation

, 2014
Closed-form solutions are presented for some one-dimensional problems involving the dynamic response of saturated porous media. These solutions are useful for validating finite element codes for dynamic consolidation of soil.
Scott Sloan (20045952), Hassan Sabetamal (20046027), John Carter (98099), Majid Nazem (8922428)   +3 more
core  

Analytical Solutions of Linear Finite-Strain One-Dimensional Consolidation

, 2002
Numerical solutions of linear finite-strain one-dimensional consolidation of both initially unconsolidated and initially fully consolidated soil layers with both one-way and two-way drainage have been available for some time. However, no solutions of the
Morris, P. H.
core   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Understanding governing equations for one-dimensional finite strain consolidation of saturated soils

Yantu gongcheng xuebao
Various forms of governing equations are available for one-dimensional finite strain consolidation of saturated soils. They are expressed using either Eulerian or Lagrangian description, each with different dependent variables, including porosity, void ...
WANG Weiyu 1, 2 , LEI Guohui 1, 2, ZHAO Xin 1, 2, DAI Chuanjie 1, 2, GU Yuxi 1, 2
doaj   +1 more source

Analytical Solution for One-dimensional Consolidation of Double-layered Soil Under Combined Action of Load and Electro-osmosis

工程科学与技术, 2022
In actual foundation treatment, electro-osmosis is often used in combination with preloading. In order to solve the deficiency in the theory about electro-osmotic consolidation solution considering both load action and layered configuration of soil, a ...
Mengfan ZONG, Chuanxun LI, Wenbing WU, Yi TIAN, Rongzhu LIANG, Guoxiong MEI   +5 more
doaj  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Affine transformations accelerate the training of physics-informed neural networks of a one-dimensional consolidation problem. [PDF]

Sci Rep, 2023
Mandl L, Mielke A, Seyedpour SM, Ricken T.   +3 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source