Results 51 to 60 of about 18,461,677 (262)

Finite Analytic Method for One-Dimensional Nonlinear Consolidation under Time-Dependent Loading

open access: yesShock and Vibration, 2017
For one-dimensional (1D) nonlinear consolidation, the governing partial differential equation is nonlinear. This paper develops the finite analytic method (FAM) to simulate 1D nonlinear consolidation under different time-dependent loading and initial ...
Dawei Cheng   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Examination on Time-Dependent Soil Models in One-Dimensional Consolidation [PDF]

open access: yes, 2013
This paper reviews the performance of two time-dependent constitutive models in predictions of one-dimensional consolidation. The Soft-Soil Creep model [1] is an example of an elastic-viscoplastic formulation that incorporates a time-dependent state ...
Yixing Yuan   +3 more
core   +1 more source

Analytical solution of one-dimensional electroosmotic consolidation considering the thermal effect

open access: yesShuiwen dizhi gongcheng dizhi
In recent years, electro-osmotic method is an effective foundation treatment method for dredged silt; however, few studies have focused on the influence of temperature on the electro-osmotic consolidation. To explore the influence of temperature field on
Qi LU, Ganbin LIU, Yongzheng MA
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A study on one-dimensional consolidation of layered systems

open access: yes, 1992
A general analytical solution for the problem of one-dimensional consolidation of layered soils is presented. A relevant computer program is developed and the computed results on some examples are included.
Y. K. Cheung   +5 more
core   +1 more source

One-dimensional consolidation of fractional order derivative viscoelastic saturated soils under arbitrary loading

open access: yesYantu gongcheng xuebao, 2017
The theory of fractional calculus is introduced into the Kelvin-Voigt constitutive model to describe the mechanical behavior of viscoelastic saturated soils.
WANG Lei 1,2, SUN De-an 1, XIE Yi 3, LI Pei-chao 3
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

open access: yesFEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı   +4 more
wiley   +1 more source

Study on Micro-Structure of Loess under one-Dimensional Consolidation

open access: yes, 2011
The SEM images were obtained from three different sections of the specimens which suffered to one-dimensional consolidation under 5 grade pressures. Basic micro-structure parameters were obtained from these SEM images and their relations with various ...
Qing Yang, Ling Xia Gao, Mao Tian Luan
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

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