Results 41 to 50 of about 56,604 (307)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Analysis of one-dimensional nonlinear consolidation of soft soil considering time-dependent loading with continuous drainage boundary

open access: yesRock and Soil Mechanics, 2022
Soil tends to have nonlinear compression characteristics, and the consolidation laws of soil are different under different compression characteristics.
WU Si-si   +4 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

Finite Difference Method for the One-Dimensional Non-linear Consolidation of Soft Ground Under Uniform Load

open access: yesFrontiers in Earth Science, 2020
Initial stress and additional effective stress distributions in soil greatly influence the degree of ground consolidation when calculating one-dimensional soft clay ground consolidation in deep soil. The one-dimensional non-linear consolidation governing
Bin-Hui Ma   +8 more
doaj   +1 more source

One-Dimensional Consolidation for Unsaturated Soils under Depth-Dependent Stress Induced by Multistage Load

open access: yes, 2022
This paper presents semianalytical solutions of one-dimensional (1D) consolidation for unsaturated soils with depth-dependent vertical stress induced by multistage load.
Lei Wang (6656)   +4 more
core  

Examination on Time-Dependent Soil Models in One-Dimensional Consolidation [PDF]

open access: yes, 2013
This paper reviews the performance of two time-dependent constitutive models in predictions of one-dimensional consolidation. The Soft-Soil Creep model [1] is an example of an elastic-viscoplastic formulation that incorporates a time-dependent state ...
Yixing Yuan   +3 more
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Analysis of deformation mechanism of soft soil reinforcement by vacuum preloading

open access: yesRock and Soil Mechanics, 2021
Based on the changes of total stress and pore water pressure in the spring model, the mechanism of vacuum preloading consolidation is studied by theoretically discussing the consolidation behavior of soil in vertical and horizontal directions with ...
HU Li-wen, LIU Zhi-jun
doaj   +1 more source

Behavior of one-dimensional consolidation under time-dependent loading

open access: yes, 2014
This paper extends Olson's solution for one-dimensional consolidation under time-dependent loading with the assumption of constant coefficient of consolidation, to those with varying loading-dependent coefficients of consolidation.
Lug, S.C., Hsu, T.W., 徐登文
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

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