Results 61 to 70 of about 56,604 (307)

INNOVATIONS IN ONE-DIMENSIONAL CONSOLIDATION TESTING: A REVIEW OF THE DOUBLE-ACTION OEDOMETER [PDF]

European Journal of Materials Science and Engineering
This study presents an in-depth evaluation of the double-action oedometer (DAO) as an advanced testing apparatus for simulating soil compressibility under near-field conditions.
OWUSU-YEBOAH Zakaria , ANICULAESI Mircea, Iancu-Bogdan TEODORU, Irina LUNGU   +3 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Effect of Vertical Pressure on Horizontal and Vertical Permeability of Soil and Effect of Surcharge Pressure on 3D Consolidation of Soil

Advances in Civil Engineering, 2018
Permeability and consolidation of soil are known as the most variable soil properties. The values of permeability and consolidation of soil may vary with depth even in case of homogeneous soil layers, and because of that, the determination of appropriate
Arpan Laskar, Sujit Kumar Pal
doaj   +1 more source

Analytical and Numerical Modelling of One-Dimensional Consolidation of Stabilized Peat [PDF]

, 2019
The objective of the paper is to compare and evaluate analytical and numerical solutions of one-dimensional consolidation of stabilized peat. The type of analytical method used to solve the problem is exact method by separation of variables and ...
Somanathan, Shamini, Wong, Leong Sing
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A piecewise-linear numerical model for one-dimensional electroosmosis consolidation

, 2012
This paper presents a piecewise-linear finite-difference model for one-dimensional electroosmosis consolidation called ECS1, based on a fixed Eulerian co-ordinate system.
Deng, A., Yadong Zhou, Zhou, Y., Deng An
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Uncertainty of One-Dimensional Consolidation of Multi-Layered Soft Clay Soils

, 2011
The measured coefficient of consolidation can have a substantial degree of variation even in a uniform clay layer. The probability characteristic values for such parameters as consolidation coefficient and compression modulus are analyzed from local ...
Xiao Yong Li
core   +1 more source