Results 91 to 100 of about 280,603 (343)

Cerebral Desaturation and One-Lung Ventilation [PDF]

Journal of Cardiothoracic and Vascular Anesthesia, 2021
Bryan E. Marchant, Scott A. Miller, Roger L. Royster   +2 more
openaire   +2 more sources

Heme‐NO Dilates Arteries via Mobilization of NO Moieties From an Intracellular NO Store Within Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Nitrosyl heme emerges as an extracellular nitrodilator that dilates arteries without crossing the cell membrane. Instead, heme‐NO mobilizes NO moieties from a preformed intracellular NO store within vascular smooth muscle, providing both functional and chemical evidence for the NANOS model, revealing a previously unrecognized mechanism of arterial ...
Taiming Liu, Meijuan Zhang, Lingchao Zhu, Haiyan Ke, Amancio de Souza, Qian Li, Daniel Castella, Nicolai Lehnert, Lubo Zhang, Arlin B. Blood   +9 more
wiley   +1 more source

Effect of propofol and isoflurane on gas exchange parameters following one-lung ventilation in thoracic surgery: a double-blinded randomized controlled clinical trial

Electronic Physician, 2018
Background: The use of anesthetic drugs with minimal inhibitory effects on the hypoxic pulmonary vasoconstriction (HPV) could have a decisive role in preventing the hypoxemia during one-lung ventilation (OLV).
Shima Sheybani, Alireza Sharifian Attar, Sogol Golshan, Shadi Sheibani, Majid Rajabian   +4 more
doaj   +1 more source

Tracheal suctioning improves gas exchange but not hemodynamics in asphyxiated lambs with meconium aspiration. [PDF]

, 2015
BackgroundCurrent neonatal resuscitation guidelines recommend tracheal suctioning of nonvigorous neonates born through meconium-stained amniotic fluid.MethodsWe evaluated the effect of tracheal suctioning at birth in 29 lambs with asphyxia induced by ...
Gugino, Sylvia F, Koenigsknecht, Carmon, Lakshminrusimha, Satyan, Mathew, Bobby, Nair, Jayasree, Nielsen, Lori, Rawat, Munmun, Swartz, Daniel D   +7 more
core  

KCNJ2 is Required for NLRP3 Inflammasome Activation That Drives Allergic Airway Inflammation and Remodeling

Advanced Science, EarlyView.
This study aims to evaluate the impact of the potassium channel KCNJ2 on asthma development. KCNJ2 promotes NLRP3 inflammasome activation through both Ca2+ influx and K+ efflux in airway epithelial cells, which drives allergic airway inflammation and remodeling, suggesting a promising therapeutic target for asthma.
Yachao Cui, Shumei Wu, Yang Peng, Yiqi Liu, Li Che, Shiying Chen, Feng Zhang, Dajiang Qin, Shiyue Li, Pixin Ran, Wenguang Yin   +10 more
wiley   +1 more source

Anaesthesia for serial whole-lung lavage in a patient with severe pulmonary alveolar proteinosis: a case report [PDF]

, 2008
Introduction Pulmonary alveolar proteinosis is a rare condition that requires treatment by whole-lung lavage. We report a case of severe pulmonary alveolar proteinosis and discuss a safe and effective strategy for the anaesthetic management of patients ...
Stephen T Webb, Adrian JR Evans, A James Varley, Andrew A Klein, BC Trapnell, J Ramirez-Rivera, R Bingisser, R Ahmed, M Moutafis, M Nadeau, R Ben-Abraham   +10 more
core   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

An investigation into the effects of commencing haemodialysis in the critically ill [PDF]

, 2012
<b>Introduction:</b> We have aimed to describe haemodynamic changes when haemodialysis is instituted in the critically ill. 3 hypotheses are tested: 1)The initial session is associated with cardiovascular instability, 2)The initial ...
Docking, R., Kinsella, J., Moss, L., Sim, M., Sleeman, D.   +4 more
core   +2 more sources

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

Distribution of Capillary Transit Times in Isolated Lungs of Oxygen-Tolerant Rats [PDF]

, 2010
Rats pre-exposed to 85% O2 for 5–7 days tolerate the otherwise lethal effects of 100% O2. The objective was to evaluate the effect of rat exposure to 85% O2 for 7 days on lung capillary mean transit time (t¯c) and distribution of capillary transit times (
AB Fisher, AB Fisher, AJ Schwab, Anne V. Clough, AV Clough, BA Freeman, BA Freeman, CA Dawson, CA Goresky, D Jamieson, David L. Roerig, DJ Kwak, E Cadenas, G Capellier, G Lenaz, JB Bassingthwaighte, JD Crapo, JD Crapo, JD Crapo, JE Heffner, JF Turrens, JM Gonzalez-Fernandez, K Howell, K Sjostrom, KH Albrecht, L Frank, Madhavi Ramakrishna, ML Zierhut, MP Merker, MP Merker, NC Staub, OD Saugstad, R Beasley, RD Bongard, RD Bongard, RE Kimball, RG Presson Jr, RG Presson Jr, Robert C. Molthen, RR Mercer, S Valenca Sdos, Said H. Audi, SH Audi, SH Audi, SH Audi, SH Audi, SH Audi, SH Audi, SH Audi, SH Audi, SH Audi, SH Audi, SH Randell, V Bhandari, V Kim, W Shi, WG Guntheroth, WS Miller, YS Ho, Zhuohui Gan   +59 more
core   +2 more sources