Results 91 to 100 of about 141,371 (299)

Optimization of treatment planning workflow and tumor coverage during daily adaptive magnetic resonance image guided radiation therapy (MR-IGRT) of pancreatic cancer [PDF]

, 2018
Background To simplify the adaptive treatment planning workflow while achieving the optimal tumor-dose coverage in pancreatic cancer patients undergoing daily adaptive magnetic resonance image guided radiation therapy (MR-IGRT). Methods In daily adaptive
Cai, Bin, Green, Olga, Kim, Jin Sung, Mutic, Sasa, Olberg, Sven, Parikh, Parag J, Park, Justin C, Rodriguez, Vivian, Yang, Deshan, Zhang, Hao   +9 more
core   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

CBCT-to-CT synthesis with a single neural network for head-and-neck, lung and breast cancer adaptive radiotherapy

, 2019
Purpose: CBCT-based adaptive radiotherapy requires daily images for accurate dose calculations. This study investigates the feasibility of applying a single convolutional network to facilitate CBCT-to-CT synthesis for head-and-neck, lung, and breast ...
Berg, Cornelis AT van den, Houweling, Anette C, Kotte, Alexis NTJ, Maspero, Matteo, Savenije, Mark HF, van Heijst, Tristan CF, Verhoeff, Joost JC   +6 more
core   +1 more source

Comparison of 3 image-guided adaptive strategies for bladder locoregional radiotherapy [PDF]

, 2018
The objective of this study was to compare the dosimetric differences of a population-based planning target volume (PTV) approach and 3 proposed adaptive strategies: plan of the day (POD), patient-specific PTV (PS-PTV), and daily reoptimization (ReOpt ...
Chung, Peter, Craig, Tim, Kong, Vickie C., Rosewall, Tara, Taylor, Amy   +4 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Comparison of cone beam computed tomography post-processing methods for online adaptive proton therapy of prostate cancer

Physics and Imaging in Radiation Oncology
Background and purpose: Although cone beam computed tomography (CBCT) enables online adaptive radiotherapy, its CT number accuracy may be insufficient for online adaptive proton therapy (OAPT). We compared proton dose distributions calculated directly on
Mislav Bobić, Daniel H. Bushe, Hoyeon Lee, Brian A. Winey, Jason A. Efstathiou, Harald Paganetti, Jennifer Pursley, Nils Peters, Lena Nenoff   +8 more
doaj   +1 more source

Four-dimensional Cone Beam CT Reconstruction and Enhancement using a Temporal Non-Local Means Method

, 2012
Four-dimensional Cone Beam Computed Tomography (4D-CBCT) has been developed to provide respiratory phase resolved volumetric imaging in image guided radiation therapy (IGRT).
Ahmad, Bergner, Buades, Combettes, Coupe, Dietrich, Feldkamp, Gilboa, Golub, Gu, Gu, Gu, Gu, Hale, Herk, Hestenes, Hissoiny, Jan-Jakob Sonke, Jia, Jia, Jia, Jia, Jia, Kriminski, Leng, Leng, Li, Li, Li, Lou, Lu, Lu, Men, Men, Samant, Segars, Sharp, Siddon, Sonke, Steve B. Jiang, Tian, Xu, Xun Jia, Yifei Lou, Zhang, Zhen Tian, Zijp   +46 more
core   +1 more source

Targeted therapies in the management of locally advanced and metastatic pancreatic cancer: a systematic review [PDF]

, 2018
Pancreatic cancer has a dismal prognosis particularly in patients presenting with unresectable tumors. We performed a bibliometric analysis of clinical trials for pancreatic cancer conducted between 2014-2016 focusing on patients that presented with ...
Biankin, Andrew V., Khachigian, Levon M., Parish, Christopher R., Sheahan, Anjali V.   +3 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Online classifier adaptation for cost-sensitive learning

, 2015
In this paper, we propose the problem of online cost-sensitive clas- sifier adaptation and the first algorithm to solve it. We assume we have a base classifier for a cost-sensitive classification problem, but it is trained with respect to a cost setting ...
Garcia, Jose, Zhang, Junlin
core   +1 more source